Recombinant Mouse Secretogranin-1 (Chgb)

中文名稱：

Recombinant Mouse Secretogranin-1(Chgb)
貨號：

CSB-YP005345MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Secretogranin-1(Chgb)
貨號：

CSB-EP005345MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Secretogranin-1(Chgb)
貨號：

CSB-EP005345MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Secretogranin-1(Chgb)
貨號：

CSB-BP005345MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Secretogranin-1(Chgb)
貨號：

CSB-MP005345MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Chgb
Uniprot No.：

P16014
別名：

Chgb; Scg-1; Scg1; Secretogranin-1; Chromogranin-B; CgB; Secretogranin I; SgI) [Cleaved into: CCB peptide; PE-11]
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

21-677
氨基酸序列

APVDNRDHNE EMVTRCIIEV LSNALSKSSV PTITPECRQV LKKSGKEVKG EEKGENQNSK FEVRLLRDPA DASGTRWASS REDAGAPVED SQGQTKVGNE KWTEGGGHSR EGVDDQESLR PSNQQASKEA KIYHSEERVG KEREKEEGKI YPMGEHREDA GEEKKHIEDS GEKPNTFSNK RSEASAKKKD ESVARADAHS MELEEKTHSR EQSSQESGEE TRRQEKPQEL TDQDQSQEES QEGEEGEEGE EGEEGEEDSA SEVTKRRPRH HHGRSGSNKS SYEGHPLSEE RRPSPKESKE ADVATVRLGE KRSHHLAHYR ASEEEPEYGE ESRSYRGLQY RGRGSEEDRA PRPRSEESQE REYKRNHPDS ELESTANRHG EETEEERSYE GANGRQHRGR GREPGAHSAL DTREEKRLLD EGHYPVRESP IDTAKRYPQS KWQEQEKNYL NYGEEGDQGR WWQQEEQLGP EESREEVRFP DRQYEPYPIT EKRKRLGALF NPYFDPLQWK NSDFEKRGNP DDSFLEDEGE DRNGVTLTEK NSFPEYNYDW WERRPFSEDV NWGYEKRSFA RAPQLDLKRQ YDGVAELDQL LHYRKKADEF PDFYDSEEQM GPHQEANDEK ARADQRVLTA EEKKELENLA AMDLELQKIA EKFSQRG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
基因功能參考文獻：
1. This analysis of mice lacking Cgs highlights the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood. PMID: 25257107
2. Chromogranin B contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles. PMID: 22415354
3. Although chromogranins regulate the amine concentration in LDCVs, they are not completely essential. PMID: 21990378
4. C-terminal domain of chromogranin B regulates intracellular calcium signaling. PMID: 22016391
5. CgB is not required for normal insulin granule biogenesis or maintenance in vivo, but is essential for adequate secretion of islet hormones PMID: 20126668
6. Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles in mice. PMID: 20089903
7. CGB was localized in the nucleus; transcription control role of CGB in the nucleus PMID: 11854265
8. Chromogranin B has a role in secretory granule biogenesis PMID: 12902350
9. CGB may play an important modulatory role in the control of Ca2+ release from the endoplasmic reticulum PMID: 14506248
10. Neuroendocrine-specific expression of Chgb is mediated by the CRE and G/C boxes in cis and the transcription factors CREB, AP-2, Egr-1 and Sp1. PMID: 16987240
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亞細胞定位：

Secreted. Note=Neuroendocrine and endocrine secretory granules.
蛋白家族：

Chromogranin/secretogranin protein family
數據庫鏈接：

KEGG: mmu:12653

STRING: 10090.ENSMUSP00000028826

UniGene: Mm.255241