在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse SH3 and PX domain-containing protein 2A (Sh3pxd2a), partial

  • 中文名稱:
    小鼠Sh3pxd2a重組蛋白
  • 貨號:
    CSB-YP021239MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Sh3pxd2a重組蛋白
  • 貨號:
    CSB-EP021239MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Sh3pxd2a重組蛋白
  • 貨號:
    CSB-EP021239MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Sh3pxd2a重組蛋白
  • 貨號:
    CSB-BP021239MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Sh3pxd2a重組蛋白
  • 貨號:
    CSB-MP021239MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Sh3pxd2a
  • Uniprot No.:
  • 別名:
    Sh3pxd2a; Fish; Sh3md1; Tks5; SH3 and PX domain-containing protein 2A; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
  • 基因功能參考文獻:
    1. Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation. PMID: 27802184
    2. This is the first study that identifies a new Rab40b-Tks5- and miR-204-dependent invadopodia transport pathway that regulates MMP2 and MMP9 secretion, and extracellular matrix remodeling during cancer progression. PMID: 27909076
    3. Results show that TKS5 is highly expressed in many cancer types with strong correlation with increased metastatic events and a poorer prognosis suggesting a clinical importance. PMID: 24993883
    4. Signaling leading to Tks5 activation in peritoneal mesothelial cells may be a suitable therapeutic target for prevention of peritoneal carcinomatosis. PMID: 25088196
    5. Tks5 undergoes an isoform switch during metastatic progression in a genetically engineered mouse model of lung adenocarcinoma PMID: 23873940
    6. Tks5, a master regulator of invadopodia in cancer cells, is crucial for osteoclast fusion downstream of phosphoinositide 3-kinase and Src. PMID: 22584907
    7. Src-Tks5 pathway is required for neural crest cell migration during embryonic development PMID: 21799874
    8. Examination of the initial stages of podosome formation has revealed an important role for the phosphoinositide PI(3,4)P(2) in anchoring the scaffold protein Tks5 to the plasma membrane. PMID: 18957242
    9. The tandem SH3A and SH3B domains of Tks5 constitute a versatile module for the implementation of isoform-specific protein-protein interactions. PMID: 19464300
    10. Tks5 facilitates the production of ROS necessary for invadopodia formation, and in turn ROS modulate Tks5 tyrosine phosphorylation in a positive feedback loop. PMID: 19755709

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell projection, podosome.
  • 蛋白家族:
    SH3PXD2 family
  • 組織特異性:
    Widely expressed. Not found in the spleen and testis.
  • 數據庫鏈接:


主站蜘蛛池模板: 国内熟妇人妻色在线视频| 秋霞在线观看秋| 久久午夜福利无码1000合集| 国产精品久久久国产盗摄| 日本午夜精品一区二区三区电影| 大香伊蕉在人线免费视频| 裸体丰满白嫩大尺度尤物| 欧美熟妇性xxxx欧美熟人多毛| 国产日韩在线时看高清视频 | yy6080久久伦理一区二区| 亚洲va天堂va欧美片a在线| 小小拗女性bbwxxxx国产| 国产精品天堂avav在线| 亚洲成a人片在线观看无码专区| 亚洲日本va午夜中文字幕一区| 在线日韩日本国产亚洲| 99视频精品全部免费免费观看| 国产小屁孩cao大人免费| 亚欧免费无码aⅴ在线观看 | 亚洲欧美国产精品久久| 亚洲精品一区二区| 亚洲成av人片无码bt种子下载| 精品性影院一区二区三区内射 | 精品国产一区二区三区四区精华液 | 又紧又黄的免费视频网站| 后入到高潮免费观看| 三级视频兔费看| 国产白嫩漂亮美女在线观看| 人摸人人人澡人人超碰97| 国产av一区二区三区日韩| 欧美激情精品久久久久久| 国产精品色拉拉| 粉嫩大学生无套内射无码卡视频| 亚洲美女又黄又爽在线观看| 日本最新免费二区| 欧美国产伦久久久久久久| 亚洲欧美另类精品二区| 成人免费一区二区三区| 国产偷伦视频片免费视频| 亚洲综合久久成人a片红豆| 中文字幕中文乱码www|