Recombinant Mouse SH2 domain-containing protein 2A (Sh2d2a)

中文名稱：

小鼠Sh2d2a重組蛋白
貨號：

CSB-YP868766MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Sh2d2a重組蛋白
貨號：

CSB-EP868766MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Sh2d2a重組蛋白
貨號：

CSB-EP868766MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Sh2d2a重組蛋白
貨號：

CSB-BP868766MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Sh2d2a重組蛋白
貨號：

CSB-MP868766MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sh2d2a
Uniprot No.：

Q9QXK9
別名：

Sh2d2a; Lad; Ribp; SH2 domain-containing protein 2A; Lck-associated adapter protein; Lad; Rlk/Itk-binding protein; Ribp
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-374
氨基酸序列

MEFCLAQPCP QGNHEATSST FNTFQPMNLT QGRCQNLSCG SRPSMQVMKE QGVQLSPRTN HTVVSASAPG TAWVLGNADR AEEVPGKGDL SLQAETRAWV QKTQAHWLLL KTAPLWFHGF ITRREAERLL QPQPLGCYLV RFSESAVTFV LSYRSQTCCR HFLLAQLGDG RHVVLGEDSA HAQLQDLLEH YTECPLSPYG EILTQPLARQ TAEPAGLSLR ADSDSGSKRQ DPDTQLSLLL QQGQAQASGH TEKVWASQQK ATSQASRPRP PIPAKPQLPP EVYTSPASRL HQAPPINPIY QEPDEPIAFY AMGRGSPGDA PSNIYAEVEG PSGTAPIGHP ILRKCWSRPI SRGQVREVQG KISSRSRAER GSPS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in p56-LCK-mediated T-cell signaling. Could be involved in the regulation of responses to T-cell activation stimuli, specifically proliferation and lymphokine production. Interactions with ITK and TXK may provide important biochemical links of these two important kinases with other components in the T-cell activation machinery.
基因功能參考文獻(xiàn)：
1. Sh2d2a protein deficient mice display reduced clearance of Dm157 MCMV infection in the spleen. PMID: 25783199
2. The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. PMID: 25492967
3. Results suggest a modulatory role for T cell specific adapter protein SH2D2A in T cell mediated immune surveillance of cancer. PMID: 23144743
4. results show that TSAd, particularly the SH2 domain of TSAd, is essential for the effector functions of T cells. PMID: 19756394
5. role of TSAd as a critical regulator of T cell death whose absence promotes systemic autoimmunity PMID: 12953096
6. TSAd appears to contribute to interleukin-2 synthesis at multiple different levels PMID: 15752554
7. The major role of T cell-specific adapter protein in peripheral T cell cytoplasm is for activation of LCK protein tyrosine kinase at the outset of T cell receptor signal transduction PMID: 16446380
8. Although Rlk/Itk-binding protein (RIBP) is coexpressed with related adaptor lymphocytes of unknown function X (ALX) protein on both T- and B-lymphocytes during cell development, no redundancy or synergy is found. PMID: 17641043
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亞細(xì)胞定位：

Cytoplasm. Cell membrane. Note=Redistributed from cytoplasm to the plasma membrane in a T-cell activation-dependent manner.
組織特異性：

Expression limited to tissues of the immune system and, in particular, activated T-cells and natural killer cells. Expressed in the thymus, lymph node, and to a lesser extent, in the spleen and bone marrow. According to PubMed:10553045, also expressed in
數(shù)據(jù)庫鏈接：

KEGG: mmu:27371

STRING: 10090.ENSMUSP00000103207

UniGene: Mm.86361