在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Retinoblastoma-like protein 2 (Rbl2), partial

Recombinant Mouse Retinoblastoma-like protein 2 (Rbl2), partial

  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-YP734133MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-EP734133MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-EP734133MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-BP734133MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-MP734133MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rbl2; Retinoblastoma-like protein 2; 130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. Loss of Rb 130 gene is associated with retinoblastoma. PMID: 27750399
    2. In skeletal dysplasias cell cycle progression is compromised in the G1 phase due to reduced phosphorylation of the pocket protein p130 leading to inhibition of transcription factors of the E2F family. PMID: 24820054
    3. Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F-containing B-Myb promoter sites. PMID: 24828495
    4. The balance between phosphorylation and acetylation of Rb2/p130 is essential for its biological function in cell cycle control. PMID: 23029429
    5. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells. PMID: 22544282
    6. Wnt/beta-catenin and pRb signal pathways interact with each other and form common p130/Gsk3beta/beta-catenin complex during MSC cycle progression. PMID: 21631154
    7. Gsk3beta, p130 and beta-catenin form in MSC a complex the functional role of which may be associated with activation of differentiation not coupled to cell cycle arrest. PMID: 21516817
    8. the control of vascular injury response is not a redundant feature of pRb proteins but primarily specific for p130 PMID: 12860570
    9. tyrosine phosphorylation sites in CAS have a role in promoting cell migration PMID: 15247284
    10. The Rbl2 protein has a role in directing full heterochromatin formation. PMID: 15750587
    11. Rb2 and kip1 have roles in controlling mobilization of angiogenic progenitors from the bone marrow PMID: 15867156
    12. p130 is a bona fide cyclin-dependent kinase inhibitor and cooperates with p27Kip1 to regulate hematopoietic cell proliferation in vivo. PMID: 16880527
    13. This study investigated if the distribution between nucleus and cytoplasm of the transcription factors E2F4 and E2F5 is mediated by pRb2/p130 and if the presence of JCV T-antigen may impair this shuttling by sequestering pRb2/p130. PMID: 17385710
    14. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. PMID: 18287052
    15. These results identify a pathway by which miR-290 directly regulates Rbl2-dependent Dnmt expression, indirectly affecting telomere-length homeostasis. PMID: 18311151
    16. Overexpression of E2F5/p130 in post-mitotic lens fiber cells does not affect normal differentiation, but can inhibit inappropriate cell cycle reentry induced by activator E2Fs. P130 is key player in inhibitory process PMID: 18385796
    17. along with p107, and Rb maintains hematopoietic stem cells quiescence and the balance between lymphoid and myeloid cell lineages PMID: 18940733
    18. these studies identify a novel proapototic function for p130 PMID: 19887614

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Retinoblastoma protein (RB) family
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 欧美人与zoxxxx另类| 成年无码av片在线免缓冲| 日本乱人伦aⅴ精品| 五十路熟女一区二区三区| 女人爽到高潮免费看视频| 亚洲色无码专区在线观看精品| 国产成人精品无码一区二区三区 | 久久久久久妓女精品影院| 国产+成+人+亚洲欧洲自线| 国产精品99久久久久久宅男| 国产一区二区| 久久久亚洲欧洲日产av| 香蕉久久av一区二区三区app| 亚洲精品自产拍在线观看亚瑟| 欧美丰满熟妇xxxx性ppx人交| 内射毛片内射国产夫妻| 女人裸露免费视频无遮挡网站 | 亚洲中文字幕乱码电影| 中文字幕无码精品亚洲资源网| 国产熟女高潮视频| 美女张开腿黄网站免费| 精品国产小视频在线观看| 正在播放熟妇群老熟妇456| 天天躁日日躁狠狠躁av中文| 免费看国产曰批40分钟| 美女裸奶100%无遮挡免费网站| 2019一級特黃色毛片免費看| 国产毛片欧美毛片久久久| 在线视频精品免费观看10| 日本国产一区二区三区在线观看| 97高清国语自产拍| 天天爽夜夜爽夜夜爽精品视频| 国产情侣疯狂作爱系列| 亚洲乱妇亚洲乱妇xinglu| 亚洲日韩中文字幕一区| 久久影院九九被窝爽爽| 永久免费观看美女裸体视频的网站| 国产一性一交一伦一a片| 日本丰满妇人成熟免费中文字幕| 无码日韩人妻av一区免费| 色综亚洲国产vv在线观看|