在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Retinoblastoma-like protein 2 (Rbl2), partial

Recombinant Mouse Retinoblastoma-like protein 2 (Rbl2), partial

  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-YP734133MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-EP734133MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-EP734133MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-BP734133MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    小鼠Rbl2重組蛋白
  • 貨號(hào)：
    CSB-MP734133MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rbl2; Retinoblastoma-like protein 2; 130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. Loss of Rb 130 gene is associated with retinoblastoma. PMID: 27750399
    2. In skeletal dysplasias cell cycle progression is compromised in the G1 phase due to reduced phosphorylation of the pocket protein p130 leading to inhibition of transcription factors of the E2F family. PMID: 24820054
    3. Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F-containing B-Myb promoter sites. PMID: 24828495
    4. The balance between phosphorylation and acetylation of Rb2/p130 is essential for its biological function in cell cycle control. PMID: 23029429
    5. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells. PMID: 22544282
    6. Wnt/beta-catenin and pRb signal pathways interact with each other and form common p130/Gsk3beta/beta-catenin complex during MSC cycle progression. PMID: 21631154
    7. Gsk3beta, p130 and beta-catenin form in MSC a complex the functional role of which may be associated with activation of differentiation not coupled to cell cycle arrest. PMID: 21516817
    8. the control of vascular injury response is not a redundant feature of pRb proteins but primarily specific for p130 PMID: 12860570
    9. tyrosine phosphorylation sites in CAS have a role in promoting cell migration PMID: 15247284
    10. The Rbl2 protein has a role in directing full heterochromatin formation. PMID: 15750587
    11. Rb2 and kip1 have roles in controlling mobilization of angiogenic progenitors from the bone marrow PMID: 15867156
    12. p130 is a bona fide cyclin-dependent kinase inhibitor and cooperates with p27Kip1 to regulate hematopoietic cell proliferation in vivo. PMID: 16880527
    13. This study investigated if the distribution between nucleus and cytoplasm of the transcription factors E2F4 and E2F5 is mediated by pRb2/p130 and if the presence of JCV T-antigen may impair this shuttling by sequestering pRb2/p130. PMID: 17385710
    14. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. PMID: 18287052
    15. These results identify a pathway by which miR-290 directly regulates Rbl2-dependent Dnmt expression, indirectly affecting telomere-length homeostasis. PMID: 18311151
    16. Overexpression of E2F5/p130 in post-mitotic lens fiber cells does not affect normal differentiation, but can inhibit inappropriate cell cycle reentry induced by activator E2Fs. P130 is key player in inhibitory process PMID: 18385796
    17. along with p107, and Rb maintains hematopoietic stem cells quiescence and the balance between lymphoid and myeloid cell lineages PMID: 18940733
    18. these studies identify a novel proapototic function for p130 PMID: 19887614

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Retinoblastoma protein (RB) family
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 国产片av国语在线观麻豆| 午夜精品久久久久久久久| 麻豆亚洲国产成人精品无码区| 久久婷婷人人澡人人爽人人喊| 亚洲国产av导航第一福利网| 国产农村妇女毛片精品久久| 国产精品无码无在线观看| 四虎亚洲精品成人a在线观看| 亚洲成在人网站无码天堂| 国产午夜精品无码一区二区| 国产精品天干天干有线观看| 午夜精品久久久久久毛片| 麻豆av一区二区三区久久| 电影内射视频免费观看| 成人特级毛片www免费版| 热99re久久精品| 毛茸茸性xxxx毛茸茸毛茸茸| 国产线观看免费观看| 67pao国产成视频永久免费 | 日日摸日日碰夜夜爽亚洲综合| 毛片无遮挡高清免费| 久久婷婷五月综合色99啪| 男男gv白嫩小受gv在线播放| 99热这里只有精品国产免费免费| 精品无码av一区二区三区不卡| 4hu四虎永久在线观看| 蕾丝av无码专区在线观看| 精品美女国产互换人妻| 日本乱偷人妻中文字幕在线| 色一情一乱一伦一区二区三区| 欧洲精品一卡2卡三卡4卡影视| 在线观看特色大片免费视频| 亚洲一区二区三区高清av| 中文天堂最新版在线www | 国产精品无码久久四虎| 再深点灬舒服灬太大了网站 | 亚洲欧洲av无码专区| 久久66热人妻偷产精品9| 香蕉av777xxx色综合一区| 亚洲成色在线综合网站| 免费大片av手机看片不卡|