在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-YP858742MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-EP858742MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-EP858742MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-BP858742MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-MP858742MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rap1b; Ras-related protein Rap-1b; GTP-binding protein smg p21B
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-181
  • 氨基酸序列
    MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS C
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
  • 基因功能參考文獻：
    1. findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase and an associated local synaptic protein translation network in this process. PMID: 26844834
    2. Rap1b deficiency promoted the transcellular route of diapedesis through endothelial cell. Increased transcellular migration of Rap1b-deficient neutrophils in vitro was selectively mediated by enhanced PI3K-Akt activation and invadopodia-like protrusions. PMID: 25092872
    3. Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone. PMID: 24790136
    4. two different activation mechanisms of Rap1b as well as novel functions of Rap1b in platelet secretion and in integrin alpha(IIb)beta(3) outside-in signaling. PMID: 21940635
    5. Rap1b-dependent VEGF-VEGFR2 activation is in part mediated via integrin alpha(v)beta(3). PMID: 21636859
    6. Upon activation, Rap1b colocalized with the scaffolding protein IQGAP1. PMID: 20733035
    7. Rap1b is oncogenic in the thyroid in ways linked to transduction of the cAMP mitogenic signal PMID: 15331589
    8. Data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target. PMID: 15696195
    9. These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells. PMID: 17993608
    10. Rap1b-mediated suppression of synaptic transmission enables plasticity in the cortico-amygdala pathway, which is required for fear learning with a moderately aversive unconditional stimulus. PMID: 18305243
    11. Rap1b-deficient B cells had impaired adhesion and reduced chemotaxis in vitro, and lessened homing to lymph nodes in vivo PMID: 18319399
    12. Rap1b is the dominant isoform in B cells and regulates cell proliferation, cell adhesion, T-dependent humoral responses, cell migration in B cells. PMID: 18714009
    13. Rap1b ameliorates glucose-induced mitochondrial dysfunction in renal tubular cells PMID: 18753253
    14. Rap1b is required for maximal GPVI-induced but not ADP-induced activation of alpha2beta1 in murine platelets. PMID: 19192113

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cytoplasm, cytosol. Cell junction.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 數據庫鏈接：


主站蜘蛛池模板： 日韩欧美mv在线观看免费| 大学生被内谢粉嫩无套| 精品国产福利久久久| 韩国主播av福利一区二区| 欧洲美熟女乱又伦| 曰韩免费无码av一区二区| 中文字幕亚洲制服在线看| 日产精品中文一区二区三区 | 无码人妻啪啪一区二区| 久久精品无码免费不卡| 四虎永久在线精品8848a| 中国6一12呦女精品| 99re热视频这里只精品| 免费人成视频网站在线观看18| 亚洲 欧美 动漫 少妇 自拍| 热99re久久精品这里都是精品| 加勒比一本heyzo高清视频| 粉嫩虎白女毛片人体| 东京热人妻丝袜无码av一二三区观| 野外做受三级视频| 性夜夜春夜夜爽aa片a | 中文字幕精品久久久久人妻红杏| 精品无码国产一区二区三区av| 少妇高潮惨叫久久久久久| 中文字幕婷婷日韩欧美亚洲| 蜜臀av片在线观看| 99精品久久精品一区二区| 精品人妻系列无码人妻免费视频| 55夜色66夜色国产精品视频| 丰满少妇在线观看网站| 国产高清成人免费视频在线观看| 亚洲国产精品一区二区第四页| 中国丰满熟妇av| 无码成a毛片免费| 欧美成人一区二区三区| 亚洲精品乱码一区二区三区| 亚洲男人最新版本天堂| 成人毛片一区二区| 欧美日韓性视頻在線| 四虎www成人影院观看| 国产亚洲精品久久久网站好莱|