在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-YP858742MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-EP858742MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-EP858742MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-BP858742MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-MP858742MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rap1b; Ras-related protein Rap-1b; GTP-binding protein smg p21B
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-181
  • 氨基酸序列
    MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS C
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
  • 基因功能參考文獻：
    1. findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase and an associated local synaptic protein translation network in this process. PMID: 26844834
    2. Rap1b deficiency promoted the transcellular route of diapedesis through endothelial cell. Increased transcellular migration of Rap1b-deficient neutrophils in vitro was selectively mediated by enhanced PI3K-Akt activation and invadopodia-like protrusions. PMID: 25092872
    3. Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone. PMID: 24790136
    4. two different activation mechanisms of Rap1b as well as novel functions of Rap1b in platelet secretion and in integrin alpha(IIb)beta(3) outside-in signaling. PMID: 21940635
    5. Rap1b-dependent VEGF-VEGFR2 activation is in part mediated via integrin alpha(v)beta(3). PMID: 21636859
    6. Upon activation, Rap1b colocalized with the scaffolding protein IQGAP1. PMID: 20733035
    7. Rap1b is oncogenic in the thyroid in ways linked to transduction of the cAMP mitogenic signal PMID: 15331589
    8. Data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target. PMID: 15696195
    9. These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells. PMID: 17993608
    10. Rap1b-mediated suppression of synaptic transmission enables plasticity in the cortico-amygdala pathway, which is required for fear learning with a moderately aversive unconditional stimulus. PMID: 18305243
    11. Rap1b-deficient B cells had impaired adhesion and reduced chemotaxis in vitro, and lessened homing to lymph nodes in vivo PMID: 18319399
    12. Rap1b is the dominant isoform in B cells and regulates cell proliferation, cell adhesion, T-dependent humoral responses, cell migration in B cells. PMID: 18714009
    13. Rap1b ameliorates glucose-induced mitochondrial dysfunction in renal tubular cells PMID: 18753253
    14. Rap1b is required for maximal GPVI-induced but not ADP-induced activation of alpha2beta1 in murine platelets. PMID: 19192113

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cytoplasm, cytosol. Cell junction.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲国产精品日本无码网站| 女人爽到高潮免费视频大全| 少妇内射兰兰久久| 狼友av永久网站免费观看孕交| 国产av亚洲精品久久久久久小说 | 日韩国产丝袜人妻一二区| 亚洲美女精品免费视频| 久久久久久亚洲精品a片成人 | 久久er热在这里只有精品66| 欧美人与善在线com| 亚洲精品一区久久久久| 国产18禁黄网站免费观看| 亚洲精品自在在线观看| 欧美人与动牲交a欧美| 少妇高潮无套内谢麻豆传| 午夜dv内射一区二区| 国产在视频线精品视频| 亚洲第一无码专区天堂| 国内熟妇人妻色无码视频在线| 亚洲国产精品综合久久20| 少妇与黑人一二三区无码| 久久永久免费专区人妻精品| 欧美自拍另类欧美综合图片区| 老熟妇仑乱一区二区视頻| 国产精品进线69影院| 国产成人精品免费视频大全软件| 无码乱码av天堂一区二区| 欧美艳星nikki激情办公室| 学生妹无套内射正在播放| 亚洲精品无码av中文字幕| 少妇久久久久久被弄到高潮| 国产精品人妻久久毛片| 婷婷成人小说综合专区| 任我爽精品视频在线播放| 国产精品国产成人国产三级| 日本少妇人妻xxxxx18| 久久午夜神器| 亚洲精品久久国产高清情趣图文| 一二三四观看视频社区在线| 精品久久久久久久无码| 少妇性l交大片|