在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Ras-related protein Rab-5A (Rab5a)

  • 中文名稱:
    小鼠Rab5a重組蛋白
  • 貨號:
    CSB-YP863418MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Rab5a重組蛋白
  • 貨號:
    CSB-EP863418MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Rab5a重組蛋白
  • 貨號:
    CSB-EP863418MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Rab5a重組蛋白
  • 貨號:
    CSB-BP863418MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Rab5a重組蛋白
  • 貨號:
    CSB-MP863418MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Rab5a; nnyRab5a; Ras-related protein Rab-5A; EC 3.6.5.2
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-215
  • 氨基酸序列
    MANRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK LPKNEPQNPG ANSARGRGVD LTEPAQPARS QCCSN
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
  • 基因功能參考文獻:
    1. The authors described a long-distance signaling mechanism of Porcine hemagglutinating encephalomyelitis virus-driven deficits in neurons and suggested that such Ulk1 repression may result in limited NGF/TrkA retrograde signaling within activated Rab5 endosomes, explaining the progressive failure of neurite outgrowth and survival. PMID: 29875237
    2. SH3GLB1 controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation. PMID: 27715385
    3. These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases. PMID: 25937276
    4. Inpp5e, through functional interactions with Rab20 on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification. PMID: 25269936
    5. FGF21 has a role in promoting endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway PMID: 24848261
    6. Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments. PMID: 21419809
    7. Data reveal the affinity of Rabex-5/Rabaptin-5/Rab5-GTP interaction in the cell, which is quantitatively related to the Rabex-5 concentration for the onset of the indirect PMID: 20169068
    8. Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5 PMID: 15328530
    9. Using retroviral expression and siRNA Rab5a silencing, data demonstrate that Rab5a is essential for the large endosome phenotype and for localization of mannose receptor. PMID: 16650848
    10. the recruitment of Gapex-5 to phagosomes through the microtubule network induces transient Rab5 activation PMID: 18385674
    11. activation of Rab5, fusion of early endosomes and phagocytosis induced by T. cruzi infection involved Toll-like receptor (TLR)2 but were independent of TLR4 receptors PMID: 18445119
    12. parasite surface ligands and host cell receptors modulate pathogen residence times in Rab5(+) phagosomes PMID: 18927250

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Cytoplasmic vesicle. Cell projection, ruffle. Membrane. Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane. Endosome membrane.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 數據庫鏈接:


主站蜘蛛池模板: 看曰本女人大战黑人视频| 在线观看无码不卡av| 中国浓毛少妇毛茸茸| 亚洲中文字幕无码一区在线| 国产成人精品综合久久久久| 亚洲乱亚洲乱妇24p| 欧美不卡一卡二卡三卡| 国产精品女上位好爽在线| 窝窝午夜精品一区二区| 久久久久国产一区二区三区| 人妻少妇久久中文字幕456| 国产亚洲福利在线视频| 一边做一边喷17p亚洲乱妇50p | 337p粉嫩大胆色噜噜噜| 久久久久久免费毛片精品| 无码一区二区三区免费| 69久久国产露脸精品国产| 欧美成人精精品一区二区| 欧洲vat一区二区三区| 天天摸天天做天天添欧美| 成人无码无遮挡很h在线播放| 欧美熟妇性xxxx欧美熟人多毛| 麻豆视传媒在线观看| 少妇做爰免费视频了| 极品尤物被啪到呻吟喷水| 秋霞午夜久久午夜精品| 国产午夜a理论毛片| 在线亚洲中文精品第1页| 婷婷射精av这里只有精品| 欧美老熟妇牲交| 国产成人精品综合久久久久| 少妇精油按摩av无码中字| 国产xxxx色视频在线观看| 国语少妇高潮对白在线| 国产精品天干天干| 亚洲国产长腿丝袜av天堂| 亚洲人成网站观看在线播放| 亚洲日本一区二区三区在线播放| 无码人妻一区、二区、三区免费视频| 粗大黑人巨精大战欧美成人| 男女做爰真人视频直播|