在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial (Pdk2), partial

Recombinant Mouse [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial (Pdk2), partial

  • 中文名稱：
    小鼠Pdk2重組蛋白
  • 貨號：
    CSB-YP867508MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pdk2重組蛋白
  • 貨號：
    CSB-EP867508MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pdk2重組蛋白
  • 貨號：
    CSB-EP867508MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pdk2重組蛋白
  • 貨號：
    CSB-BP867508MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pdk2重組蛋白
  • 貨號：
    CSB-MP867508MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pdk2; [Pyruvate dehydrogenase; acetyl-transferring)] kinase isozyme 2; mitochondrial; EC 2.7.11.2; Pyruvate dehydrogenase kinase isoform 2; PDH kinase 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 表達區域：
    -
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
  • 基因功能參考文獻：
    1. our results suggest that PDK2/4 can be a potential target for the development of pharmacotherapy for the treatment of acute inflammatory pain PMID: 26931482
    2. The current study reports that increasing hepatic PDC activity by inhibition of PDK2 ameliorates hepatic steatosis and insulin sensitivity by regulating TCA cycle anaplerosis and ketogenesis. The findings suggest PDK2 is a potential therapeutic target for nonalcoholic fatty liver disease. PMID: 27385159
    3. PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy. PMID: 26769971
    4. These findings reveal that there are divergent roles of PDKs during oocyte maturation and indicate a new mechanism controlling meiotic structure. PMID: 25991547
    5. Double-knockout mice with global deletion of PDK2 and PDK4, which results in constitutively activated pyruvate dehydrogenase, preferentially oxidize glucose in muscle. PMID: 25368185
    6. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2. PMID: 24356970
    7. The Pdk4 gene knockdown led to better glucose tolerance than the Pdk2 gene knockdown. PMID: 23940800
    8. loss of both Pdk2 and Pdk4 attenuated HSC quiescence, glycolysis, and transplantation capacity. PMID: 23290136
    9. Results established that wild-type p53 prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 suppresses tumorigenesis acting at the level of cancer cell metabolism. PMID: 22123926
    10. PDK2 activity is essential, even at rest, in regulation of carbohydrate oxidation and production of reducing equivalents for the electron transport chain. PMID: 21411764
    11. mitochondrial ND2 mutation contributes to HIF1alpha accumulation via increased ROS production, up-regulation of PDK2, attenuating PDH activity, thereby increasing pyruvate, resulting in HIF1alpha stabilization PMID: 19147752

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    PDK/BCKDK protein kinase family
  • 組織特異性：
    Detected in heart (at protein level).
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲精品久久久久久婷婷| 黄网在线观看免费网站| 成熟丰满熟妇高潮xxxxx| 国产精品午夜福利视频234区 | 日韩免费视频| 日日狠狠久久8888偷偷色| 亚洲色欲www综合网| 中文字幕+乱码+中文乱码www| 亚洲桃色天堂网| 国产肉体xxxx裸体784大胆| 久久精品aⅴ无码中文字字幕重口| 寂寞少妇做spa按摩无码| 久久www免费人成_看片| 亚洲日本乱码在线观看| 人妻无码久久一区二区三区免费| 亚洲精品乱码久久久久久日本| 亚洲精品久久久一二三区| 香港三日本三级少妇三级2021| 成熟妇女性成熟满足视频| 男女裸体影院高潮| 日韩一本之道一区中文字幕 | 亚洲日韩中文字幕久热| 国产精品国产精品国产专区不卡| 日日橹狠狠爱欧美超碰| 亚洲精品国产综合久久一线| 中日韩va无码中文字幕| 日本无遮挡边做边爱边摸| 老子午夜精品无码不卡| 永久黄网站色视频免费无下载| 色天使久久综合给合久久97色| 亚洲乱码一区二区三区在线观看 | 亚洲狠狠婷婷综合久久| 亚洲一卡2卡三卡四卡精品| 午夜无码片在线观看影院y| 黑人巨大av无码专区| 国产成人无码一区二区在线观看| 婷婷色中文字幕综合在线| 蜜臀性色av免费| 少妇人妻偷人激情视频| 少妇把腿扒开让我爽爽视频| 亚洲欧美日韩在线资源观看|