在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Protein sprouty homolog 4 (Spry4)

Recombinant Mouse Protein sprouty homolog 4 (Spry4)

  • 中文名稱：
    小鼠Spry4重組蛋白
  • 貨號：
    CSB-YP892974MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Spry4重組蛋白
  • 貨號：
    CSB-EP892974MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Spry4重組蛋白
  • 貨號：
    CSB-EP892974MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Spry4重組蛋白
  • 貨號：
    CSB-BP892974MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Spry4重組蛋白
  • 貨號：
    CSB-MP892974MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Spry4
  • Uniprot No.：
  • 別名：
    Spry4; Protein sprouty homolog 4; Spry-4
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-300
  • 氨基酸序列
    MEPPVPQSSV PVNPSSVMVQ PLLDSRAPHS RLQHPLTILP IDQMKTSHVE NDYIDNPSLA PATGPKRPRG GPPELAPTPA RCDQDITHHW ISFSGRPSSV SSSSSTSSDQ RLLDHMAPPP VAEQASPRAV RLQPKVVHCK PLDLKGPTAP PELDKHFLLC EACGKCKCKE CASPRTLPSC WVCNQECLCS AQTLVNYGTC MCLVQGIFYH CTNEDDEGSC ADHPCSCSGS NCCARWSFMG ALSVVLPCLL CYLPATGCVK LAQRGYDRLR RPGCRCKHTN SVICKAASGD TKTSRSDKPF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin.
  • 基因功能參考文獻：
    1. A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. PMID: 29964027
    2. Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations. PMID: 28732181
    3. We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased. PMID: 25541251
    4. SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia subtype. PMID: 25822087
    5. In vivo analysis revealed that Spry4 regulated integrin beta3 levels in murine embryos and yolk sacs. PMID: 23955631
    6. Spry4, an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under control of a doxycycline-inducible system. PMID: 12781690
    7. Transgenic expression of murine Spry4 during beta-cell carcinogenesis does not significantly affect tumor outgrowth and progression to tumor malignancy. PMID: 18337453
    8. Periodic expression of Sprouty4 is controlled by the Notch segmentation clock and may work as a mediator that links the temporal periodicity of clock gene oscillations with the spatial periodicity of boundary formation. PMID: 19440349
    9. Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. PMID: 19493272

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein.
  • 蛋白家族：
    Sprouty family
  • 組織特異性：
    Expressed in the embryo and adult tissues including heart, brain, lung, kidney, and skeletal muscle.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品久久久久影院| 精品aⅴ一区二区三区| 暖暖 免费 高清 日本 在线| 亚洲vav在线男人的天堂| 中文亚洲无线码49vv| 男人扒开女人双腿猛进免费视频 | 激情国产av做激情国产爱| 一边捏奶一边高潮视频| 夜夜春夜夜爽| 久久精品99久久香蕉国产色戒| 亚洲欧美中文字幕5发布| 亚洲aⅴ无码专区在线观看| 亚洲美女视频高清在线看| 久久精品www人人做人人爽 | 精品人妻无码区在线视频| 亚洲乱码无人区卡1卡2卡3| 国产精品无码久久综合网| 午夜精品射精入后重之免费观看| 国产欧美va天堂在线观看视频| 亚洲中文字幕无码久久精品1| 精品国产午夜肉伦伦影院| 粉嫩虎白女毛片人体| 亚洲爆乳aaa无码专区| 免费无码又爽又刺激网站| 国产在线精品一区二区不卡麻豆| 老牛精品亚洲成av人片| 无码东京热一区二区三区| 亚洲bbw性色大片| 日本精品人妻无码77777| 亚洲国产成人久久一区二区三区| 国产激情无码视频在线播放| 国产成人精品一区二区不卡| av大尺度一区二区三区| 人人妻人人澡人人爽久久av| 99e久热只有精品8在线直播| av色国产色拍| 人妻无码专区一区二区三区| 欧美性色19p| 看成年女人午夜毛片免费| 久久精品国产首页027007| 精品国产卡一卡2卡3卡|