Recombinant Mouse Protein spire homolog 2 (Spire2)

中文名稱：

小鼠Spire2重組蛋白
貨號：

CSB-YP811689MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Spire2重組蛋白
貨號：

CSB-EP811689MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Spire2重組蛋白
貨號：

CSB-EP811689MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Spire2重組蛋白
貨號：

CSB-BP811689MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Spire2重組蛋白
貨號：

CSB-MP811689MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Spire2
Uniprot No.：

Q8K1S6
別名：

Spire2; spir-2; Protein spire homolog 2; Spir-2
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-718
氨基酸序列

MARAGGGGAA APERAGGAAR PEPWELSLEE VLKVYEQPIN EEQAWAVCFQ GCRGLRGEPG GVRRIRDTAD ILLRRDGSVG ARLEPEPTTM VVPPASSEAQ MVQSLGFAIY RALDWGLDEN EERELSPQLE RLIDLMANSD CEDSSCGAAD EGYVGPEEEE EAEGGPRAVR TFAQAMRLCA LRLTDPHGAQ AHYQAVCRAL FVETLELRAF LARVREAKEM LKKLGEEEPR EKPLAELDHL GHTDWARLWV QLMRELRHGV KLKKVQEKEF NPLPTEFQLT PFEMLMQDIR ARNYKLRKVM VDGDIPPRVK KDAHELILDF IRSRPPLKQV SERQLRPVPQ KQRTLHEKIL EEIKQERRLR PVGAQHLGGR GFGSLPCILN ACSGDIKSTS CINLSVTDTG SGSQRPRPRV LLKAPTLAEM EEMNTSEEEE SPCGEVALKR DRSFSEHDLA QLRSEMASGL QSAAQPPGGT EPPRARAGSM HSWRPSSRDQ GFCPVSGQSQ PLPSSALPSS LSSVDGPEAA SPDTRHLWLE FSHPVESLAL TVEEVVDVRR VLVKAEMERF LQDKELFSSL KRGKICCCCR AKFPLFSWPP TCLFCKRAVC TSCSVKMKMP SKKYGHIPVY TLGFESLQRV PTTKATPTLR RDAFQSLQGP KWRSVEEEFP HIYAHGCVLK DVCSDCTSFV ADVVCSSRKS VDVLNATPRR SRQTQSLYIP NTRTLNFQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage.
基因功能參考文獻：
1. The authors determined crystal structures of MyoVa-globular tail domain bound either to the Spir-2 motif or to Rab11 and show that a Spir-2:MyoVa:Rab11 complex can form. PMID: 27623148
2. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection. PMID: 23577770
3. Spire1 and Spire2 drive two critical steps of asymmetric oocyte division PMID: 21620703
4. Spir-2 is found to be expressed as a single mRNA in the developing nervous system and intestine. In adult mouse it is expressed in epithelial cells of the digestive tract, in neuronal cells of the nervous system, and in testical spermatocytes. PMID: 20723621
亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Spire family
組織特異性：

Detected in oocytes.
數(shù)據(jù)庫鏈接：

KEGG: mmu:234857

STRING: 10090.ENSMUSP00000010298

UniGene: Mm.150200