在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein phosphatase 1 regulatory subunit 14A (Ppp1r14a)

  • 中文名稱:
    小鼠Ppp1r14a重組蛋白
  • 貨號:
    CSB-YP838672MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Ppp1r14a重組蛋白
  • 貨號:
    CSB-EP838672MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Ppp1r14a重組蛋白
  • 貨號:
    CSB-EP838672MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Ppp1r14a重組蛋白
  • 貨號:
    CSB-BP838672MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Ppp1r14a重組蛋白
  • 貨號:
    CSB-MP838672MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Ppp1r14a; Cpi17; Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-147
  • 氨基酸序列
    MAAQRLGKRV LSKLQSPSRA RGPGGSPSGL QKRHARVTVK YDRRELQRRL DVEKWIDGCL EELYRGRESD MPDEVNIDEL LELDSEEERC RKIQGLLEAC ANPTEDFVQE LLAKLRGLHK QPGFPQPSPS DDPSLSPRQD RAHTAPP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
  • 基因功能參考文獻:
    1. CPI-17 phosphorylation at T38 is essential for the maintenance of physiological blood pressure. PMID: 29229685
    2. Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1alpha but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy. PMID: 25724497
    3. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). PMID: 23275439
    4. a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17. PMID: 22275376
    5. Data suggest that CPI-17 and both conventional and novel PKC isozymes contribute to the phasic and tonic contractile components of BALB/c colonic circular smooth muscle. PMID: 22093175
    6. Organ-specific mechanisms involving MYPT1, M-RIP, and CPI-17 are critical to regulating basal LC20 phosphorylation in gastrointestinal smooth muscles. PMID: 21883701
    7. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals PMID: 20086008
    8. distribution of mouse and rat PPP1R14A was more specific and different from that of humans PMID: 11931393
    9. concluded that actions downstream of cGMP/PKG can reverse PKC-mediated phosphorylation of CPI-17 and Ca(2+) sensitization in smooth muscle PMID: 15123611
    10. findings suggest that CPI-17 was downregulated during intestinal inflammation and that TNF-alpha plays a central role in this process. Downregulation of CPI-17 may play a role in motility impairments in inflammation. PMID: 17307724
    11. CPI-17 expression is reversibly controlled in response to the phenotype transition of smooth muscle cells that restricts the signal to differentiated smooth muscle cells and particular cell types. PMID: 19437030

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    PP1 inhibitor family
  • 數據庫鏈接:


主站蜘蛛池模板: 在线a亚洲视频播放在线观看| 正在播放国产剧情亂倫| 国产精品国产精品国产专区不卡| 日本被黑人强伦姧人妻完整版| 久久中文字幕人妻av熟女| 日本高清va在线播放| 欧美xxxx黑人又粗又长| 久9视频这里只有精品| 丰满少妇被猛烈进入| 日本欧美一区二区三区在线播放| 国产精品va在线播放| 欧美不卡一区二区三区| 高清无码一区二区在线观看吞精| 日本真人边吃奶边做爽动态图| 久久这里有精品国产电影网| 色窝窝无码一区二区三区成人网站| 青春草在线视频免费观看| 性中国妓女毛茸茸视频| 天堂中文官网在线| 丰满人妻熟妇乱又伦精品软件| 老子午夜理论影院理论| 亚洲v欧美v日韩v国产v| 美女内射毛片在线看3d| 天天爽夜夜爽夜夜爽精品视频| 亚洲 欧美 另类 制服 日韩| 亚洲中文字幕无码av正片| 日本熟妇乱子伦xxxx| 色婷婷av久久久久久久| 亚洲欧洲日本无在线码| 国产一卡2卡3卡4卡精品| 伴郎粗大的内捧猛烈进出视频观看| 国产欧美va欧美va香蕉在| 人人人插人人费| 国产精品亚洲专区无码破解版| 青青草国产成人99久久| 东京热一精品无码av| 国产一区二区亚洲精品 | 娜娜麻豆国产电影| 国产精品久久久久久久久久妞妞| 看成年女人午夜毛片免费| 亚洲精品综合在线影院 |