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  4. Recombinant Mouse Protein hairless (Hr), partial

Recombinant Mouse Protein hairless (Hr), partial

  • 中文名稱：
    小鼠Hr重組蛋白
  • 貨號：
    CSB-YP713982MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hr重組蛋白
  • 貨號：
    CSB-EP713982MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hr重組蛋白
  • 貨號：
    CSB-EP713982MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hr重組蛋白
  • 貨號：
    CSB-BP713982MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hr重組蛋白
  • 貨號：
    CSB-MP713982MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hr
  • Uniprot No.：
  • 別名：
    HrLysine-specific demethylase hairless; EC 1.14.11.-
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle.
  • 基因功能參考文獻：
    1. Changes in the expression of Hr result in hair loss or regrowth. PMID: 28679963
    2. hypomorphic mutation essential for the full development of diet-induced pruritic atopic skin PMID: 26998821
    3. This study examinedthe uncommon phenotype and using microarray analyses and functional studies, we found that beta-catenin was mediated by Hr. Progenitor keratinocytes from the bulge region differentiate into both epidermis and sebaceous glands, and fail to adopt the hair keratinocytes fate in the mutant scalp, due to the decreased Wnt/beta-catenin signaling in the absence of the hairless protein. PMID: 28765044
    4. the putrescine-HR negative regulatory loop may have a large impact on epidermal homeostasis and hair follicle cycling PMID: 24079733
    5. HR regulates expression of genes in the MSX2 regulatory pathway, which explains abnormal hair follicle formation in Hr(Hp)/Hr(Hp) skin. PMID: 23702391
    6. Mutation within mouse hr protein leads to phenotype of hairlessness. PMID: 23903062
    7. Hairless is required for adipocyte differentiation. PMID: 22964757
    8. Hr loss results in a state of uncontrolled epidermal proliferation that promotes tumor development, and Hr mutant mice should no longer be considered merely hairless 'wild-type' mice PMID: 22761871
    9. Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. PMID: 21777520
    10. Hr evokes an anti-apoptotic response by disrupting a p53 dependent pathway involving Bcl2 family members. PMID: 20886113
    11. Hr mutants display partial hair loss at an early age and progress to near alopecia. PMID: 19897589
    12. Mutation of the Hr gene results in congenital hair loss in both mice and men PMID: 20087431
    13. novel nonsense mutation (Hrrh-R) and molecular basis for hair loss and role of Hr in hair follicle biology PMID: 20080498
    14. hairless phenotype in CR rats is not allelic with mouse hairless PMID: 11926302
    15. This thyroid hormone-regulated corepressor associates with histone deacetylases in neonatal rat brain. PMID: 12403844
    16. HR regulates the timing of epithelial cell differentiation in both the epidermis and hair follicle PMID: 15280217
    17. Two polymorphisms and a homozygous transition for a G-->A at nucleotide position 3110 (exon 12) leading to the substitution of tryptophan by a nonsense codon, designated W911X. This allele was named rhinocerotic and short-lived, with the symbol hr(rhsl). PMID: 15955095
    18. HR regulates the precise timing of Wnt signaling required for hair follicle regeneration. PMID: 16195376
    19. Results provided new data for SNPs in Hr gene. PMID: 16378938
    20. A novel missense mutation in the hr gene causes irreversible alopecia. PMID: 16455232
    21. TRalpha is the major thyroid hormone receptor regulating hairless expression in the cerebellum of young mouse pups PMID: 16571082
    22. Hr(N) does not appear to be an allele of Hr but may result from a mutation in a closely linked gene or from a regulatory mutation in Hr. PMID: 17330134
    23. HR bmh protein displays an abnormal cellular localization in transfected cell lines, as well as in the epidermis and hair follicle of bmh mutant mice PMID: 17657241
    24. A T-to-A transversion mutation in Hr causes abnormal hair follicle morphogenesis in mouse. PMID: 19513791

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  • 相關疾病：
    Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:15460

    STRING: 10090.ENSMUSP00000022691

    UniGene: Mm.7598



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