在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein Tob1 (Tob1)

  • 中文名稱:
    小鼠Tob1重組蛋白
  • 貨號:
    CSB-YP726749MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Tob1重組蛋白
  • 貨號:
    CSB-EP726749MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Tob1重組蛋白
  • 貨號:
    CSB-EP726749MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Tob1重組蛋白
  • 貨號:
    CSB-BP726749MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Tob1重組蛋白
  • 貨號:
    CSB-MP726749MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Tob1
  • Uniprot No.:
  • 別名:
    Tob1; Tob; Trob; Protein Tob1; Transducer of erbB-2 1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-362
  • 氨基酸序列
    MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY KGSGFRCIHV GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS YQIGEKGPVK VLYVDDSSET GCELDKEIKN SFNPEAQVFM PISDPASSVS SSPSPPFGHS AAVSPTFMPR STQPLTFTTA TFAATKFGST KMKNSGRSSK VARTSPINLG LTVNVNDLLK QKAISSSVHS LYGLGLGSQQ QPQPQPQQQQ QQQPSSSQPP PPLPQQQQQQ PQQQQQQQQQ TSALSPNAKE FIFPNMQGQG SSTNGMFPGD SPLNLSPLQY SNAFDVFAAY GGLNEKSFVD GLNFSLNNMQ YSNQQFQPVM AN
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
  • 基因功能參考文獻:
    1. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. PMID: 27546286
    2. MiR-26a exerts its effect by directly targeting Tob1, the negative regulator of BMP/Smad signaling pathway by binding to the 3'-untranslated region and thus repressing Tob1 protein expression PMID: 26050992
    3. Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis PMID: 26807845
    4. Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. PMID: 24945807
    5. Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs) grew faster than wild type (WT) ESCs without losing pluripotency. PMID: 25951976
    6. The expression of Tob1 was significantly increased at day 6 during C2C12 differentiation time, suggesting a possible role in skeletal muscle development. PMID: 21845080
    7. Experimental autoimmune encephalomyelitis in Tob1-eficient mice is associated with augmented central nervous system inflammation, increased infiltrating CD4+ and CD8+ T cell counts, and increased myelin-reactive Th1 and Th17 cells PMID: 23797093
    8. Tob1 is a crucial check point molecule that modulates the expression and activity of cell cycle proteins. PMID: 20513747
    9. Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation PMID: 12050114
    10. deficiency prevents ovariectomy-induced bone loss through the superenhancement of osteoblastic activities in bone and that this results in further augmentation in the bone formation rate and the mineral apposition rate after ovariectomy in vivo PMID: 15100414
    11. regulation of nuclear localization of Tob is important for its antiproliferative activity PMID: 15235587
    12. KLF2 and TOB1 activate the mouse Dpp2 promoter. PMID: 18555530

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
  • 蛋白家族:
    BTG family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:


主站蜘蛛池模板: 精品国精品自拍自在线 | 亚洲精品无码中文久久字幕| 国产午夜成人免费看片app| 欧美顶级少妇作爱| 中文字幕精品无码一区二区| 尹人香蕉久久99天天拍欧美p7| 国产性生大片免费观看性| 亚洲成熟丰满熟妇高潮xxxxx| 小妖精又紧又湿高潮h视频69 | 无码 制服 丝袜 国产 另类| 精品丝袜人妻久久久久久| 蜜桃av亚洲精品一区二区| 午夜无码国产理论在线| 成人免费无码大片a毛片抽搐色欲| 羞羞视频在线观看| 国产av久久久久精东av| 国产成年无码久久久免费| 三个男吃我奶头一边一个视频 | 风韵人妻丰满熟妇老熟女| 成人免费无码不卡毛片视频| 国产精品免费视频网站| 欧美精品国产aⅴ一区二区在线| 又粗又紧又湿又爽的视频| 无码综合天天久久综合网色吧影院 | 国产亚洲精品合集久久久久| 欧美真人性做爰一二区| 熟女人妻水多爽中文字幕| 亚洲国产精品一区第二页| 国产蜜芽尤物在线一区| 欧美精品黑人粗大免费| 久久偷看各类wc女厕嘘嘘| 无码高潮少妇毛多水多水免费| 日韩欧无码一区二区三区免费不卡| 亚洲中国精品精华液| 国产成人无码www免费视频播放 | 国产成人精品日本亚洲成熟| 久久久久99精品成人片试看| 精品av无码国产一区二区| 国内少妇偷人精品免费| 久久精品亚洲精品无码白云tv| 免费观看的av毛片的网站|