Recombinant Mouse Protein CREG1 (Creg1)

中文名稱：

Recombinant Mouse Protein CREG1(Creg1)
貨號(hào)：

CSB-YP005957MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

Recombinant Mouse Protein CREG1(Creg1)
貨號(hào)：

CSB-EP005957MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

Recombinant Mouse Protein CREG1(Creg1)
貨號(hào)：

CSB-EP005957MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Protein CREG1(Creg1)
貨號(hào)：

CSB-BP005957MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Protein CREG1(Creg1)
貨號(hào)：

CSB-MP005957MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Creg1
Uniprot No.：

O88668
別名：

Creg1; CregProtein CREG1; Cellular repressor of E1A-stimulated genes 1
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

32-220
氨基酸序列

RGGRDHGDW DVDRRLPPLP PREDGPRVAR FVTHVSDWGS LATISTIKEV RGWPFADIIS ISDGPPGEGT GEPYMYLSPL QQAVSDLQEN PEATLTMSLA QTVYCRNHGF DPQSPLCVHI MMSGTVTKVN KTEEDYARDS LFVRHPEMKH WPSSHNWFFA KLKISRIWVL DYFGGPKVVT PEEYFNVTLQ
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
基因功能參考文獻(xiàn)：
1. Transplantation of CREG-modified embryonic stem cells exhibits a favorable survival pattern in infarcted hearts, which translates into a substantial preservation of cardiac function after acute myocardial infarction. PMID: 29684345
2. CREG protects heart against MI/R injury-induced cardiomyocytes apoptosis by activating lysosomal autophagy. PMID: 27840305
3. CREG1 interacts with Sec8 to promote cardiomyogenic differentiation and cell-cell adhesion. PMID: 27334848
4. Study demonstrated that haplodeficiency of Creg1 exacerbated high fat diet-induced obesity, insulin resistance and dyslipidemia. In addition, Creg1+/- mice showed increased systemic and adipose tissue inflammation, possibly through activation of the NF-kappaB pathway. PMID: 28459882
5. CREG is a novel mediator of vascular remodeling in response to Ang II. PMID: 28062494
6. CREG inhibits inflammation and promotes autophagy mediated by lysosome formation; it might be a potential therapeutic target in atherosclerosis. PMID: 26163874
7. CREG1 deficiency influenced the maturation of lysosomes and reduced the espression of Rab7, which might be involved in CREG1-induced cardiomyocyte autophagy. PMID: 25774384
8. Data indicate cellular repressor of E1A-stimulated gene (CREG) as a factor in regulating endothelial differentiation and vasculogenesis via VEGF/PI3K/Akt pathway. PMID: 24896346
9. Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. PMID: 23040447
10. CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF/PI3K/AKT signaling pathway PMID: 21872252
11. These results indicate that CREG is expressed during mouse embryogenesis and might participate in the differentiation of these organs during embryogenesis. PMID: 20857207
12. Results show that CREG is a lysosomal protein that undergoes proteolytic maturation during biosynthesis, carries the mannose 6-phosphate recognition marker and depends on the interaction with M-6-P receptors for efficient delivery to lysosomes. PMID: 18621046
13. Secreted Creg inhibits cell proliferation mediated by mannose-6-phosphate/insulin-like growth factor II receptor in NIH 3T3 fibroblasts. PMID: 18691225
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亞細(xì)胞定位：

Secreted.
蛋白家族：

CREG family
組織特異性：

Widely expressed.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:433375

UniGene: Mm.294885