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  4. Recombinant Mouse Probable ATP-dependent RNA helicase DDX58 (Ddx58), partial

Recombinant Mouse Probable ATP-dependent RNA helicase DDX58 (Ddx58), partial

  • 中文名稱：
    Recombinant Mouse Probable ATP-dependent RNA helicase DDX58(Ddx58) ,partial
  • 貨號：
    CSB-YP764829MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Probable ATP-dependent RNA helicase DDX58(Ddx58) ,partial
  • 貨號：
    CSB-EP764829MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Probable ATP-dependent RNA helicase DDX58(Ddx58) ,partial
  • 貨號：
    CSB-EP764829MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Probable ATP-dependent RNA helicase DDX58(Ddx58) ,partial
  • 貨號：
    CSB-BP764829MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Probable ATP-dependent RNA helicase DDX58(Ddx58) ,partial
  • 貨號：
    CSB-MP764829MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ddx58; Antiviral innate immune response receptor RIG-I; DEAD box protein 58; Probable ATP-dependent RNA helicase DDX58; EC 3.6.4.13; RIG-I-like receptor 1; RLR-1; Retinoic acid-inducible gene 1 protein; RIG-1; Retinoic acid-inducible gene I protein; RIG-I
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. Ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Sendai virus (SeV), Rhabdoviridae and Flaviviridae. It also detects rotavirus and orthoreovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome. Detects dsRNA produced from non-self dsDNA by RNA polymerase III. May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.
  • 基因功能參考文獻：
    1. FBXW7 is critical for RIG-I stabilization during antiviral responses. PMID: 28287082
    2. Identification of a second binding site on the RIG-I TRIM25 B30.2 domain has been reported. PMID: 29259080
    3. Elevated retinoic acid-inducible gene 1 (RIG-I) modulated the interaction of activated proto-oncogene c-Src (Src) and STAT3 by competitive binding to STAT3. PMID: 27349479
    4. innate immune signaling mediated by RLR plays a critical role in nuclear reprogramming. PMID: 28276156
    5. Toll-like receptor 2 (TLR2) and retinoic acid-inducible gene I (RIG-I) cooperatively initiate innate immune responses to MuV infection in mouse ovarian granulosa cells. PMID: 27477784
    6. Collectively, these results uncover an independent functional contribution of the apo-Rig-I/Stat3 interaction in the maintenance of Treg/Th17 cell balance. PMID: 28550197
    7. The RIG-I, as well as the adaptor protein mitochondrial antiviral signaling protein, regulates NF-kappaB-mediated induction of adhesion molecules and proinflammatory cytokine expression in response to LPS. PMID: 27183587
    8. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation PMID: 26862753
    9. identifies DDX58 and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1 PMID: 26525917
    10. Cytosolic LMW FGF2 functions as a negative regulator in RIG-I-mediated antiviral signaling. PMID: 26466960
    11. findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response PMID: 25843799
    12. The results describe a novel, interactive relationship between RIG-I downstream signalling molecules resulting in efficient anti-viral immunity. PMID: 25158146
    13. senses hepatitis B virus RNA, and counteracts HBV polymerase PMID: 25557055
    14. RIG-I-like receptor (RLR) signaling pathway was significantly affected by Yersinia pestis infection PMID: 25064677
    15. the suppression of RIG-I induction and antiviral cytokine responses by Cigarette smoke are likely important in the enhanced susceptibility of smokers to influenza infection in the lung. PMID: 25260755
    16. the minimal determinant for RIG-I recognition is a base-paired RNA with 5'pp; such RNAs are found in some viruses but not in uninfected cells, so recognition of 5'pp-RNA acts as a powerful means of self/non-self discrimination by the innate immune system PMID: 25119032
    17. Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs. PMID: 25172485
    18. Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA/MAVS for ubiquitination and degradation. PMID: 24729608
    19. Overexpression of USP21 inhibited RNA virus-induced RIG-I polyubiquitination and RIG-I-mediated interferon signaling, while USP21 deletion resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN production, and antiviral responses. PMID: 24493797
    20. The current study demonstrates that melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-I) initiate the testicular innate antiviral response. PMID: 23820901
    21. Data show that the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I-like receptors. PMID: 24270516
    22. Although ZAP was known as a regulator of RIG-I signaling in a human cell line, ZAP deficiency does not affect the RIG-I-dependent production of type I IFN in mouse cells PMID: 23836649
    23. these findings suggest that mast cells produce cytokines and chemokines in the early infection stage after recognizing viruses via RIG-I and MDA5, and may contribute to antiviral responses. PMID: 23171655
    24. combining TGF-beta gene silencing with RIG-I signaling confers potent antitumor efficacy against pancreatic cancer by breaking tumor-induced CD8(+) T cell suppression PMID: 23338611
    25. Rift Valley fever virus-induced activation of IFN-beta is dependent on RIG-I. PMID: 23408632
    26. Rig-I regulates NF-kappaB activity through binding to Nf-kappab1 3'-UTR mRNA. PMID: 23553835
    27. influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production. PMID: 23209422
    28. Data reveal a negative feedback loop of RIG-I signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses. PMID: 23374343
    29. The finding that RIG-I responds to S. flexneri infection during the IFNgamma response extends the range of PRRs that are capable of recognizing this bacterium. PMID: 22912573
    30. HCV PAMP motif drives potent RIG-I signaling to induce the innate immune response to infection. PMID: 22912574
    31. analysis of inhibition of influenza A virus infection by gene silencing through 5'-Triphosphate-short interfering RNA and RIG-I activation PMID: 22787226
    32. This study shows that activation of the cytoplasmatic nucleic acid receptor RIG-I leads to endothelial dysfunction. RIG-I induced endothelial damage could therefore be an important pathway in atherogenesis. PMID: 22402283
    33. RIG-I as an innate immune sensor of cytosolic HIV genomic RNA with secondary structure PMID: 22235281
    34. The activation of RIG-I occurs through an RNA- and ATP-driven structural switch in the SF2 domain. PMID: 21979817
    35. Arterivirus and nairovirus deubiquitinases target RIG-I to control innate immune signaling. PMID: 22072774
    36. The inhibitory effects of poly(I:C) are mediated by retinoic acid-inducible gene (RIG)-like helicase (RLH) PMID: 21278304
    37. Klotho suppresses RIG-I-mediated senescence-associated inflammation PMID: 21336305
    38. Among the rabies virus N protein mutants those with mutations at positions 273 and 394 evaded activation of RIG-I-mediated signaling most efficiently and also showed the highest pathogenicity. PMID: 20875468
    39. RIG-1 - MAVS interacts with cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I - NF- kappa B-inducing kinase signaling pathway [RIG-1 (RARRES3, TIG3)] PMID: 18550535
    40. Rig-I has a critical regulatory role in modulating the generation and differentiation of granulocytes [RIG-I, also callede RARRES3 or TIG3] PMID: 18650396
    41. Phosphorylation-mediated negative regulation of RIG-I antiviral activity. PMID: 20071582
    42. Results identify the CARD9-Bcl-10 module as an essential component of the RIG-I dependent proinflammatory signaling for interleukin 1 beta production in response to certain RNA viruses. PMID: 19915568
    43. RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). PMID: 16039576
    44. A disparate regulatory role for DExD/H box RNA helicase LGP2 in the triggering of innate immune signaling pathways following RNA virus infection. PMID: 17475874
    45. Findings suggest that Rig-I has crucial roles in the regulation of G alpha i2 expression and T-cell activation, and the development of colitis may be associated with downregulation of G alpha i2 and disturbed T-cell homeostasis. PMID: 17893708
    46. RIG-I plays a key role in the regulation of tumor necrosis factor (TNF)-alpha expression via Toll-like receptor-4 signaling pathway in macrophages in response to lipopolysaccharide stimulation. PMID: 18523264
    47. results provide a conceptual advance by defining specific homopolymeric RNA motifs within the genome of HCV and other RNA viruses as the PAMP (pathogen-associated molecular patterns) substrate of RIG-I PMID: 18548002
    48. It is a molecule that senses viral RNA in cytoplasms and plays a roll in the signal transduction and innate immunity. (review) PMID: 18975620
    49. RIG-I interacts with poly-I/C in vivo, and that heteropolymeric dsRNA and poly-I/C interact directly with RIG-I in vitro, but in different ways. PMID: 19115016
    50. Data show that activation of p38 MAPK by RIG-I proceeds via a TRAF2-TAK1-dependent pathway, where the enzymatic activity of the kinase plays an essential role. PMID: 19224920

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  • 亞細胞定位：
    Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction.
  • 蛋白家族：
    Helicase family, RLR subfamily
  • 數據庫鏈接：


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