在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Potassium voltage-gated channel subfamily E member 1 (Kcne1), partial

Recombinant Mouse Potassium voltage-gated channel subfamily E member 1 (Kcne1), partial

  • 中文名稱：
    小鼠Kcne1重組蛋白
  • 貨號：
    CSB-YP012025MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kcne1重組蛋白
  • 貨號：
    CSB-EP012025MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kcne1重組蛋白
  • 貨號：
    CSB-EP012025MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kcne1重組蛋白
  • 貨號：
    CSB-BP012025MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kcne1重組蛋白
  • 貨號：
    CSB-MP012025MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcne1
  • Uniprot No.：
  • 別名：
    Kcne1; Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; mISK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
  • 基因功能參考文獻：
    1. SUMOylation of KCNQ1 is KCNE1 dependent and determines the native attributes of cardiac IKs in vivo. PMID: 28743749
    2. The electrophysiological effects of BACE1 on KCNQ1 reported here were independent of its enzymatic activity. PMID: 26454161
    3. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation PMID: 26410412
    4. KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells. PMID: 23504710
    5. In clearance studies the KCNE1 knockout mice had an increased fractional excretion of Na+, Cl-, HCO3(-) and water. PMID: 21576273
    6. This study confirmed that KCNE1 channels are necessary for K+ secretion in developmental Saccule and Utricle in mice. PMID: 22090480
    7. Beta-adrenergic receptor-regulated I Ks channels can play a role in atrial fibrillation. PMID: 18006587
    8. both the voltage-dependence and kinetics of gating were found to depend on the relative densities of KCNQ1 and KCNE1, suggesting the heart rhythm may be regulated by the relative expression of the auxiliary subunit PMID: 20962273
    9. Findings directly implicate triggered electrical activity and spatial and temporal re-entrant mechanisms in the arrhythmogenesis observed in KCNE1 (-/-) hearts. PMID: 19430811
    10. intestinal Cl(-) secretion is independent from KCNE1 but requires KCNQ1 and in mouse pancreatic acini KCNQ1 probably co-assembled with KCNE1 leads to a voltage-dependent K(+) current that might be of importance for electrolyte and enzyme secretion. PMID: 11889581
    11. the spatial expression of minK-lacZ in the adult mouse heart has been shown, for the larger part, to be coincident with the conduction tissues PMID: 12741710
    12. The transitory transfection of kcne1 restores both Cl- and K+ swelling-activated currents, confirming the implication of KCNE1 protein in the cell-volume regulation in PCT cells in primary cultures. PMID: 12962276
    13. KCNE1 is associated with an arrhythmogenic phenotype that shows an increased dispersion of conduction velocities PMID: 14561835
    14. The HCO3- dependent regulatory volume decrease in isolated renal proximal tubule cells requires normal expression of KCNE1. PMID: 15123546
    15. analysis of the IsK/KvLQT1 potassium channel in a new corticosteroid-sensitive cell line derived from the inner ear PMID: 16478723
    16. Our findings suggest an important role for LIMP2 in the control of the localization and the level of apically expressed membrane proteins such as KCNQ1, KCNE1 and megalin in the stria vascularis. PMID: 16901941
    17. In juvenile mice, the KCNE1 mutation was associated with a strong decrease in the expression of the calcium-binding proteins calbindin, calretinin and parvalbumin within the medial vestibular nucleus PMID: 17627998
    18. these data indicate that KCNE1 and KCNE3 interact directly with Kv12.2 channels to regulate channel membrane trafficking PMID: 19623261

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Membrane raft.
  • 蛋白家族：
    Potassium channel KCNE family
  • 組織特異性：
    Restrictively localized in the apical membrane portion of epithelial cells.
  • 數據庫鏈接：


主站蜘蛛池模板： 人人妻人人澡人人爽人人dvd| 好大好硬好爽免费视频| 亚洲精品无码av中文字幕| 亚洲小说春色综合另类| 免费久久人人爽人人爽av| 国产亲子乱弄免费视频| 无码h肉动漫在线观看免费| 双腿高潮抽搐喷白浆视频| 精品无码乱码av| 在线播放国产精品三级| 国产成人无码性教育视频| 久久中文字幕人妻av熟女| 久久久精品2019免费观看| 在线看免费无码av天堂的| 国产黄a三级三级三级| 亚洲国产天堂久久综合| 精品亚洲国产成人蜜臀优播av| 在线不卡av片免费观看| 久久久亚洲精品一区二区三区浴池| 国模无码一区二区三区| 国产蝌蚪视频一区二区三区| 欧美影视精品久久| 日韩欧美群交p片內射中文| 又粗又大又硬又长又爽| 中文字幕乱码人在线视频1区 | 人妻少妇偷人无码视频 | 熟女少妇丰满一区二区| 午夜精品久久久久久久无码| 色婷婷久久综合中文久久一本| 亚洲中文无码av永久伊人| 亚洲一区二区三区日本久久九| 激情综合五月| 无码中文人妻在线三区| 亚洲成a人片在线观看天堂| 中文无码天天av天天爽| 国产在线精品一区二区不卡麻豆| 日本熟妇色一本在线观看| 激情射精爽到偷偷c视频无码| 天美麻花果冻视频大全英文版 | 伊人久久大香线焦av综合影院| 欧美又大又色又爽aaaa片|