在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Potassium voltage-gated channel subfamily A member 2 (Kcna2), partial

Recombinant Mouse Potassium voltage-gated channel subfamily A member 2 (Kcna2), partial

  • 中文名稱：
    小鼠Kcna2重組蛋白
  • 貨號：
    CSB-YP012007MO1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kcna2重組蛋白
  • 貨號：
    CSB-EP012007MO1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kcna2重組蛋白
  • 貨號：
    CSB-EP012007MO1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kcna2重組蛋白
  • 貨號：
    CSB-BP012007MO1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kcna2重組蛋白
  • 貨號：
    CSB-MP012007MO1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcna2
  • Uniprot No.：
  • 別名：
    Kcna2; Potassium voltage-gated channel subfamily A member 2; MK2; Voltage-gated potassium channel subunit Kv1.2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure. In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation. Contributes to the regulation of action potentials in neurons. KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons. Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination. KCNA2-containing channels play a role in GABAergic transmission from basket cells to Purkinje cells in the cerebellum, and thereby play an import role in motor coordination. Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus. May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons. May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA). Contributes to the regulation of the axonal release of the neurotransmitter dopamine. Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain. Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep.
  • 基因功能參考文獻：
    1. G9a contributes to neuropathic pain development through epigenetic silencing of Kcna2 in the axotomized dorsal root ganglion. PMID: 27874088
    2. Results show that MK2 activation induces MRTF-A phosphorylation at S351 and S371 upon stress. PMID: 27492266
    3. Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells PMID: 26047212
    4. analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics PMID: 23413033
    5. This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines. PMID: 23264053
    6. Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38/Mk2 is involved in this inflammatory response. PMID: 23381627
    7. The dynamic Sig-1R-Kv1.2 complex represents a mechanism that shapes neuronal and behavioral response to cocaine. PMID: 23332758
    8. the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated. PMID: 21233214
    9. These results suggest that independent of known mutations in Kcna1 encoding Kv1.1, Kcna2 mutations may be important molecular correlates underlying human cerebellar ataxic disease. PMID: 20696761
    10. Data show that PSD-95 colocalizes precisely with Kv1 potassium channels and Caspr2 at juxtaparanodes, and that a macromolecular complex of Kv1 channels and PSD-95 can be immunopurified from mammalian brain and spinal cord. PMID: 12438413
    11. Kcna2-null mice exhibited increased seizure susceptibility but, in contrast to Kcna1-null mice, hypoexcitability and enlarged Kv1 currents in auditory neurons. PMID: 17634333
    12. Kv1.2, a mammalian homologue of Shaker, regulates neuronal excitability and affects NREM sleep PMID: 17925011
    13. cluster of cytoplasmic C-terminal phosphorylation sites regulates Kv1.2 trafficking PMID: 18056633
    14. K(v)1.1 and K(v)1.2 were predominantly expressed in distinct EGC phenotypes. K(v)1.2 was also observed in distinct neuron subpopulations. PMID: 19549557

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Membrane. Cell projection, axon. Cell junction, synapse. Endoplasmic reticulum membrane. Cell projection, lamellipodium membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, presynaptic cell membrane. Cell projection, dendrite. Perikaryon. Cell junction, paranodal septate junction.
  • 蛋白家族：
    Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.2/KCNA2 sub-subfamily
  • 組織特異性：
    Detected in brain. Detected in cerebellum. Detected in mitral cells in the olfactory bulb. Detected in cochlea. Detected in cerebellum, particularly in the basket cell axon plexus and in the terminal regions around Purkinje cells. Detected in juxtaparanod
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲一区二区三区四区 | a级大胆欧美人体大胆666| 国产av一二三无码影片| 亚洲v欧美v国产v在线观看| 午夜天堂av天堂久久久| 国产成人小视频| 人人做人人爽国产视| 国产偷窥盗摄一区二区| 中国少妇xxxx做受| 国精品无码一区二区三区左线| 无码任你躁久久久久久久| 国产亚洲精品久久久久9999| 亚洲国产日韩制服在线观看| 麻豆果冻传媒2021精品传媒一区| 熟女体下毛毛黑森林| 日韩a无v码在线播放| 久久久久人妻精品区一三寸| 亚洲精品久久久久午夜福禁果tⅴ| 一本色道无码不卡在线观看| 日本强伦片中文字幕免费看| 新版天堂8中文在线最新版官网| 久久精品无码av| 播放男人添女人下边视频| 国产白嫩漂亮美女在线观看| 国产成人夜色高潮福利影视| 欧美精品色婷婷五月综合| 久久五月精品中文字幕| 三级做a全过程在线观看| 中文字幕一区日韩精品| 无码成人一区二区| 国产性夜夜春夜夜爽1a片| 国产av久久久久精东av| 成人亚洲a片v一区二区三区动漫| 久久精品人妻无码一区二区三区| 成人免费视频在线观看| 四虎精品国产永久在线观看| 人人爽人人爱| 3d动漫精品一区二区三区| 亚洲龙腾成小说人网| 亚洲乱色熟女一区二区三区丝袜| 内射老妇bbwx0c0ck|