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  4. Recombinant Mouse Plasma membrane calcium-transporting ATPase 2 (Atp2b2), partial

Recombinant Mouse Plasma membrane calcium-transporting ATPase 2 (Atp2b2), partial

  • 中文名稱：
    Recombinant Mouse Plasma membrane calcium-transporting ATPase 2(Atp2b2) ,partial
  • 貨號：
    CSB-YP882599MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Plasma membrane calcium-transporting ATPase 2(Atp2b2) ,partial
  • 貨號：
    CSB-EP882599MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Plasma membrane calcium-transporting ATPase 2(Atp2b2) ,partial
  • 貨號：
    CSB-EP882599MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Plasma membrane calcium-transporting ATPase 2(Atp2b2) ,partial
  • 貨號：
    CSB-BP882599MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Plasma membrane calcium-transporting ATPase 2(Atp2b2) ,partial
  • 貨號：
    CSB-MP882599MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Atp2b2; Pmca2Plasma membrane calcium-transporting ATPase 2; PMCA2; EC 7.2.2.10; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk.
  • 基因功能參考文獻：
    1. Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system PMID: 28532435
    2. These findings indicate a novel role for PMCA2 in modality- and sex-dependent pain responsiveness. Female-specific molecular changes potentially account for the altered pain responses PMID: 27702770
    3. PMCA2 interacts with HER2 in specific actin-rich membrane domains. PMID: 26729871
    4. These results indicate that a significant fraction of the postsynaptic NMDAR current is reliant on a perisynaptic extracellular alkaline shift generated by the PMCA. PMID: 25609607
    5. Our results demonstrate that PMCA2 activity is an important regulator of the dendritic calcium equilibrium controlling Purkinje cell dendritic growth PMID: 24288624
    6. This study further resolves the interaction between Atp2b2 and Cdh23 in a gene dosage and frequency-dependent manner, and finds that low auditory frequencies are significantly affected by the interaction. PMID: 23792079
    7. loss of PMCA2 adversely influences the function and organisation of Purkinje neuron synaptic inhibition PMID: 23568408
    8. The Atp2b2 (Deaf13) mutation leads to a p. R561S substitution in the catalytic core. Mice homozygous for these mutations display profound hearing loss. PMID: 23826306
    9. Amplitude of depolarization and AMPAR-mediated Ca(2+) transients are significantly higher in cultured PMCA2(+/-) than in PMCA2(+/+) Purkinje cells due to increased Ca(2+) influx. PMID: 22789621
    10. G293S and V586M mutations in the PMCA2 Calcium Transporting ATPase of the stereocilia are associated with deafness. (Review) PMID: 22349217
    11. Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2. PMID: 22252018
    12. PMCA1 but not PMCA2 localization is compromized by the loss of Cav1.4 protein. PMID: 22183401
    13. The murine mutant of PMCA2 overexpressed in model cells (HeLa) displayed an evident defect both in the basal activity of the Ca(2+)pump and in the long range ejection of Ca(2+). PMID: 22047666
    14. Whole cell patch clamp recordings from PMCA2-/- PNs revealed that they possessed hyperpolarised membrane potentials, reduced frequency and increased irregularity of spontaneous action potential firing. PMID: 21232211
    15. Data link the reduction in PMCA2 expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE. PMID: 20489728
    16. PMCA2 missense mutation, Tommy, impairs cytosolic calcium clearance in hair cells and Tommy mice show hearing impairment. PMID: 20826782
    17. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer PMID: 20534448
    18. Although PMCA2(+/-) mice exhibited outwardly normal behaviour and little change in their gait pattern, when challenged to run on a narrow beam they exhibited clear deficits in hindlimb coordination. PMID: 20083513
    19. In homozygous mice structural changes in cochlear hair cells, spiral ganglion neurones and spherical cells in the cochlear nucleus result from PMCA2 mutation and the subsequent accumulation of toxic levels of calcium that alter their functional integrity. PMID: 11875276
    20. Fifteen days following an 8 h, 113 dB noise exposure, Pmca2+/- mice displayed significant permanent threshold shifts at 16 and 32 kHz that were 15 or 25 dB greater than those observed in Pmca2+/+ littermates. PMID: 11950541
    21. PMCA2 is localized to rod bipolar cells, horizontal cells, amacrine cells, and ganglion cells PMID: 12209837
    22. the activity of PMCA2bw is required for secretion of much of the calcium in milk PMID: 15302868
    23. Hearing loss and ataxia are dependent on gene dosage and PMCA2 dysfunction. PMID: 15350283
    24. PMCA2, located in hair cell stereocilia, contributes significantly to endolymph calcium maintenance. PMID: 15357414
    25. Loss of motor neurons in the spinal cord of PMCA2 null and PMCA2 dfw(23) functionally null mutation mice. PMID: 15576480
    26. Decrease in PMCA2 transcript and protein levels and correlation between expression and disease course in two different allergic encephalomyelitis models further highlight the importance of this calcium pump in neuronal dysfunction during inflammation. PMID: 15926914
    27. PMCA2-mediated Ca2+ extrusion modulates the amplitude and timing of the high-sensitivity rod pathway to a much greater extent than that of the cone pathway PMID: 16822977
    28. Fast PMCA2 isoform strongly influences development and maintenance of cerebellar function. PMID: 17409239
    29. even partial reductions in PMCA2 levels are sufficient to cause delayed death of motor neurons in disease PMID: 18848933
    30. Oblivion, a new Atp2b2 mutant showed a missense mutation (2630C-->T) in exon 15, causing a serine to phenylalanine substitution (S877F) in transmembrane domain 6 of the PMCA2 pump, the resident Ca(2+) pump of hair cell stereocilia,leading to deafness PMID: 18974863
    31. The deaf-waddler isoform of PMCA2, operating at 30% efficacy, showed a significantly decreased ability to rescue the Ca(2+) loading of cells expressing TRPML3(A419P). PMID: 19299509

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  • 相關疾病：
    Atp2b2 null deficient mice are deaf.
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell junction, synapse.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily
  • 組織特異性：
    Expressed in the retina, with strongest levels in the inner plexiform layer, weaker levels in the outer plexiform layer, and very low levels in the proximal inner nuclear layer. Specifically expressed in the following retinal cell types: rod bipolar cells
  • 數據庫鏈接：


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