在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Phosphatidylinositol 3-kinase regulatory subunit beta (Pik3r2)

  • 中文名稱:
    小鼠Pik3r2重組蛋白
  • 貨號:
    CSB-YP018005MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Pik3r2重組蛋白
  • 貨號:
    CSB-EP018005MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Pik3r2重組蛋白
  • 貨號:
    CSB-EP018005MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Pik3r2重組蛋白
  • 貨號:
    CSB-BP018005MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Pik3r2重組蛋白
  • 貨號:
    CSB-MP018005MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Pik3r2; Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-beta
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-722
  • 氨基酸序列
    MAGAEGFQYR AVYPFRRERP EDLELLPGDL LVVSRVALQA LGVADGGERC PHNVGWMPGF NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP LDGSSESGHI LPDLAEQFSP PDPAPPILVK LVEAIEQAEL DSECYSKPEL PATRTDWSLS DLEQWDRTAL YDAVKGFLLA LPAAVVTPEA AAEAYRALRE VAGPVGLVLE PPTLPLHQAL TLRFLLQHLG RVARRAPSPD TAVHALASAF GPLLLRIPPS GGEGDGSEPV PDFPVLLLER LVQEHVEEQD AAPPALPPKP SKAKPAPTAL ANGGSPPSLQ DAEWYWGDIS REEVNERLRD TPDGTFLVRD ASSKIQGEYT LTLRKGGNNK LIKVFHRDGH YGFSEPLTFC SVVELISHYR HESLAQYNAK LDTRLLYPVS KYQQDQVVKE DSIEAVGAQL KVYHQQYQDK SREYDQLYEE YTRTSQELQM KRTAIEAFNE TIKIFEEQGQ TQEKCSKEYL ERFRREGNEK EMQRILLNSE RLKSRIAEIH ESRTKLEQDL RAQASDNREI DKRMNSLKPD LMQLRKIRDQ YLVWLTQKGA RQRKINEWLG IKNETEDQYS LMEDEDALPH HEERTWYVGK INRTQAEEML SGKRDGTFLI RESSQRGCYA CSVVVDGDTK HCVIYRTATG FGFAEPYNLY GSLKELVLHY QHASLVQHND ALTVTLAHPV RAPGPGPPSA AR
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
  • 基因功能參考文獻:
    1. p85beta deficiency does not alter NK cell differentiation and maturation in spleen or bone marrow. NK cells from p85beta(-/-) mice nonetheless produced more IFN-gamma and degranulated more effectively when stimulated with anti-NKG2D antibody. p85beta deficiency impaired NKG2D internalization, which could contribute to the activated phenotype. PMID: 27381007
    2. Activation of PI3K (p110beta and p85beta), and phospho-AKT (Ser473), participated in the regulation of activating macrophages by wear particles, ultimately resulting in the secretion of TNF-alpha. PMID: 23330804
    3. miR-126-mediated phosphoinositide-3-kinase regulation, not only fine-tunes VEGF-signaling, but it strongly enhances the activities of Ang-1 on vessel stabilization and maturation. PMID: 22867989
    4. p85beta phosphoinositide 3-kinase subunit regulates tumor progression PMID: 22733740
    5. study shows that p110beta nuclear localization signal and p85beta nuclear export sequence regulate p85beta/p110beta nuclear localization, supporting the idea that nuclear, but not cytoplasmic, p110beta controls cell survival PMID: 21383062
    6. These results indicate that the p85beta regulatory isoform has partially overlapping functions with p85alpha in B cells as well as a unique role in opposing BCR responses. PMID: 19811262
    7. Involvement of p85beta in CD28-mediated activation and differentiation of antigen-stimulated T cells. PMID: 19190244

    顯示更多

    收起更多

  • 蛋白家族:
    PI3K p85 subunit family
  • 數據庫鏈接:


主站蜘蛛池模板: 热久久视久久精品18| 欧美亚洲日本国产黑白配| 亚洲 欧美 中文 日韩aⅴ| 亚洲va在线∨a天堂va欧美va| 欧美日韩午夜群交多人轮换| 成人免费无遮挡无码黄漫视频| 少妇spa推油被扣高潮| a毛片终身免费观看网站| 男女一边摸一边做爽爽| 中文字幕v亚洲ⅴv天堂| 精品av中文字幕在线毛片| 久久精品视频在线看| 中文字幕日产无码| 男女同房做爰爽免费| 无码人妻丝袜在线视频红杏| 欧洲精品免费一区二区三区| 极品少妇被后入内射视| 久久亚洲中文字幕伊人久久大 | 国产深夜福利视频在线| 中文天堂网www新版资源在线| 日本护士╳╳╳hd少妇| 精品少妇人妻av久久久| 在线播放国产麻豆va剧情| 影音先锋女人av鲁色资源网久久| 欧美又粗又长又爽做受| 少妇被粗大的猛进出69影院 | 国产又黄又大又粗的视频| 中文字幕日韩精品无码内射| 久久国产精品免费一区| 护士被强女千到高潮视频| 在厨房拨开内裤进入毛片| 亚洲日产av中文字幕无码偷拍| 无人去码一码二码三码区| 少妇人妻偷人精品无码视频| 国产成人精品福利网站| 夜夜澡天天碰人人爱av| 中文字幕乱码免费| 中字幕人妻一区二区三区| 12裸体自慰免费观看网站| 巨大巨粗巨长 黑人长吊| 国产av无码久久精品|