在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Peripheral myelin protein 22 (Pmp22), partial

Recombinant Mouse Peripheral myelin protein 22 (Pmp22), partial

  • 中文名稱：
    小鼠Pmp22重組蛋白
  • 貨號(hào)：
    CSB-YP018241MO1
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pmp22重組蛋白
  • 貨號(hào)：
    CSB-EP018241MO1
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pmp22重組蛋白
  • 貨號(hào)：
    CSB-EP018241MO1-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pmp22重組蛋白
  • 貨號(hào)：
    CSB-BP018241MO1
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pmp22重組蛋白
  • 貨號(hào)：
    CSB-MP018241MO1
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pmp22
  • Uniprot No.：
  • 別名：
    Pmp22; Gas-3; Gas3; Pmp-22; Peripheral myelin protein 22; PMP-22; Growth arrest-specific protein 3; GAS-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
  • 基因功能參考文獻(xiàn)：
    1. selective suppression of the Pmp22 mutant allele by non-viral delivery of siRNA alleviates the demyelinating neuropathic phenotypes of Charcot-Marie-Tooth disease in vivo PMID: 28108290
    2. We discovered that Tead1 and co-activators Yap and Taz are required for Pmp22 expression, as well as for the expression of Egr2 Tead1 directly binds Pmp22 and Egr2 enhancers early in development and Tead1 binding is induced during myelination, correlating with Pmp22 expression. The data identify Tead1 as a novel regulator of Pmp22 expression during development in concert with Sox10 and Egr2 PMID: 27288457
    3. The basal lamina and PMP22 act in concert to contribute to a resilience and integrity of peripheral nerves at the single fibre level. PMID: 25446378
    4. A role was identified for PMP22 in the linkage of the actin cytoskeleton with the plasma membrane. PMID: 25429154
    5. This study demonistrated that Paranodal dysmyelination in peripheral nerves of Trembler mice. PMID: 24446165
    6. This study showed that a number of ongoing pathogenic mechanisms contribute to the progression of the neuropathy in C22 mice, which initiates with abnormal expression of PMP22. PMID: 24175617
    7. This study revealed a novel mechanism by which PMP22 deficiency affects nerve conduction not through removal of myelin, but through disruption of myelin junctions PMID: 24339129
    8. This study showed that mouse PMP22 is palmitoylated at C85 and mutating C85S abolishes PMP22 palmitoylation. PMID: 23127255
    9. Peripheral myelin protein 22 (PMP22) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath. PMID: 21824506
    10. Egr2 and Sox10 activity are directly involved in mediating the developmental induction of Pmp22 expression through an intronic enhancer. PMID: 21411665
    11. The results of this study demonstrated that a function of Pmp22 is to protect the nerve from mechanical injury. PMID: 20071523
    12. Part of the PMP22 gene contains the necessary information to mirror the endogenous expression pattern in peripheral nerves during development and regeneration and in mouse models of demyelination due to genetic lesions. PMID: 12056842
    13. Association of calnexin ex vivo: a basis for "gain-of-function" ER diseases. PMID: 12119418
    14. Aggresome formation has now been observed with two mutant PMP22s, the Tr- and TrJ-PMP22 when the proteasome is inhibited. two pathways of PMP22 degradation are present. PMID: 12127149
    15. Mutant pmp22 from less severely affected mutants occurs in large aggregates, while that from more severely affected mutants occurs in a diffuse perinuclear pattern. Pmp22 aggregates may be protective in this form of peripheral neuropathy. PMID: 12359155
    16. Multiple distinct signaling pathways regulating Pmp22 expression in myelination as well as in neurons converge on distinct segments of the PMP22 promoter region. PMID: 14664827
    17. Recessive mutations were uniquely distinguished from dominant mutations by both the low potential for aggregation and their trafficking to the cell surface. PMID: 15474367
    18. Increased expression of genes involved in cell cycle regulation and DNA replication is characteristic and specific for early development in Pmp22-deficient mice, supporting a primary function of PMP22 in the regulation of Schwann cell proliferation. PMID: 15755691
    19. PMP22 is a binding partner in the integrin alpha6beta4/laminin complex and is involved in mediating the interaction of Schwann cells with the extracellular environment. PMID: 16436605
    20. The beneficial effects of autophagy and chaperones in preventing the accumulation of misfolded PMP22 are additive and provide a potential avenue for therapeutic approaches in hereditary neuropathies linked to PMP22 mutations. PMID: 17174099
    21. Data show that Med25 is coordinately expressed with Pmp22 gene dosage and expression in transgenic mice and rats, and suggest a potential role of this protein in the molecular etiology of Charcot-Marie-Tooth disease. PMID: 19290556

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    A defect in Pmp-22 is the cause of trembler (tr) phenotype. Trembler mice show a Schwann cells defect characterized by severe hypomyelination and continuing Schwann cells proliferation throughout life.
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PMP-22/EMP/MP20 family
  • 組織特異性：
    Schwann cells of the peripheral nervous system.
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 国产伦精品一区二区三区| 精品无码国产污污污免费| 亚洲 欧美 日韩 综合aⅴ| 国产二级一片内射视频播放| 成人亚洲欧美久久久久| 国产aⅴ精品一区二区三区| 国产麻豆剧传媒精品国产av| 久久久免费精品re6| 无码h黄肉动漫在线观看| 亚洲精品av一区午夜福利| 久久伊人蜜桃av一区二区| 7m精品福利视频导航| 久久视频在线视频精品| 最新在线精品国自产拍福利| 欧美激情精品久久| 国语精品福利自产拍在线观看| 人妻无码vs中文字幕久久av爆| 真实国产精品vr专区| 国内偷窥一区二区三区视频| 国产9 9在线 | 欧洲| 国产午夜无码视频在线观看| 国产亚洲精品久久yy5099| 久久国产精品老女人| 搡女人真爽免费视频大全| 国产中年熟女高潮大集合| 日本人妻中文字幕乱码系列| 好男人社区影院www| 亚洲国产成人综合精品| 色欲av巨乳无码一区二区| 无码人妻精品一区二区三区下载 | 国产性夜夜春夜夜爽1a片| 人妻影音先锋啪啪av资源| 亚洲人成网站在小说| 狠狠色综合网丁香五月| 黄页网站在线观看免费视频| 狂野欧美激情性xxxx按摩| 日韩人妻无码一区二区三区| 日产精品一区2区卡四卡二卡| 午夜亚洲国产理论片中文| 国产精品毛片久久久久久久| 国产精品亚洲成在人线|