在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Peptidyl-prolyl cis-trans isomerase FKBP4 (Fkbp4)

Recombinant Mouse Peptidyl-prolyl cis-trans isomerase FKBP4 (Fkbp4)

  • 中文名稱：
    小鼠Fkbp4重組蛋白
  • 貨號：
    CSB-YP008700MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fkbp4重組蛋白
  • 貨號：
    CSB-EP008700MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fkbp4重組蛋白
  • 貨號：
    CSB-EP008700MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fkbp4重組蛋白
  • 貨號：
    CSB-BP008700MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fkbp4重組蛋白
  • 貨號：
    CSB-MP008700MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Fkbp4; Fkpb52Peptidyl-prolyl cis-trans isomerase FKBP4; PPIase FKBP4; EC 5.2.1.8; 52 kDa FK506-binding protein; 52 kDa FKBP; FKBP-52; 59 kDa immunophilin; p59; FK506-binding protein 4; FKBP-4; FKBP59; HSP-binding immunophilin; HBI; Immunophilin FKBP52; Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4; N-terminally processed]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-458
  • 氨基酸序列
    MTAEEMKAAE NGAQSAPLPL EGVDISPKQD EGVLKVIKRE GTGTETPMIG DRVFVHYTGW LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAVATMKVG EVCHITCKPE YAYGAAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIRTRGEG YARPNDGAMV EVALEGYHKD RLFDQRELCF EVGEGESLDL PCGLEEAIQR MEKGEHSIVY LKPSYAFGSV GKERFQIPPH AELRYEVRLK SFEKAKESWE MSSAEKLEQS NIVKERGTAY FKEGKYKQAL LQYKKIVSWL EYESSFSGEE MQKVHALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG EAHLAVNDFD LARADFQKVL QLYPSNKAAK TQLAVCQQRT RRQLAREKKL YANMFERLAE EEHKVKAEVA AGDHPTDAEM KGERNNVAEN QSRVETEA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
  • 基因功能參考文獻：
    1. Study demonstrates that FKBP52 by itself does not directly affect cognition and may play an indirect, modulatory role in the functional pathology of Alzheimer's disease, whereas it directly affects motor coordination, an early sign of neurodegenerative damages to the brain. PMID: 27418439
    2. identify a novel steroid-responsive FKBP52-dependent pathway suppressing the expression and activity of tryptophan-2,3-dioxygenase PMID: 25132599
    3. study identifies Fkbp4 and Fkbp5 as novel components of the Ago2 RISC loading complex PMID: 24049110
    4. FKBP52 is not involved in all branches of GR signaling, but rather acts in a gene-specific manner to regulate GR transcriptional activation. PMID: 22641006
    5. FKBP52 regulates androgen receptor function through the BF3 surface. PMID: 21730179
    6. Findings suggest that Fkbp52 deficiency diminishes the threshold against OS by reducing PRDX6 levels. PMID: 20713718
    7. Fkbp52 is an important molecular regulator in the androgen-mediated pathway of urethra morphogenesis. PMID: 20605780
    8. Data propose a model in which FKBP52 loss reduces GR control of gluconeogenesis, predisposing the liver to steatosis under HF-diet conditions attributable to a shunting of metabolism from glucose production to lipogenesis. PMID: 20427484
    9. a Hoxa10-FKBP52 signaling axis is critical to uterine receptivity and implantation PMID: 15528267
    10. FKBP52 is an AR folding factor that has critically important physiological roles in some male reproductive tissues PMID: 15831525
    11. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. PMID: 16176985
    12. indispensability of FKBP52 in uterine progesterone/progesterone receptor signaling is a function of genetic disparity and is pregnancy stage specific PMID: 17571166
    13. phosphorylation of the FK linker appears to be an important regulatory determinant of FKBP52-mediated potentiation of steroid receptor activity PMID: 17717070
    14. These results suggest that the FK1 domain, and in particular the loop overhanging the catalytic pocket, is critically involved in receptor interactions and receptor activity. PMID: 17938211
    15. Data show that the loss of FKBP52 encourages the growth of endometriotic lesions with increased inflammation, cell proliferation, and angiogenesis. PMID: 18988805
    16. FKBP52 does not contribute to all branches of GR signaling. PMID: 19073255

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton.
  • 數(shù)據庫鏈接：


主站蜘蛛池模板： 色噜噜狠狠色综合网| 亚洲熟妇无码一区二区三区导航| 天天干天天射天天操| 偷看农村女人做爰毛片色| 国产一区二区三区四区精华| 国产成人综合久久免费| 一边吃奶一边做动态图| 国产日韩欧美| (无码视频)在线观看| 精品久久久久中文字幕加勒比| 秋霞国产精品一区二区| 狠狠躁18三区二区一区ai明星| 婷婷久久综合九色综合88| 人妻少妇精品视频无码综合| 一本大道东京热无码视频| 伊人色合天天久久综合网 | 大战丰满无码人妻50p| 国产精品网站在线观看免费传媒| 国产69精品久久久久app下载| 九色精品国产成人综合网站| 一区二区三区国产精华液| 国产人妻人伦精品| 亚洲一区二区三区香蕉| 国产在线看片免费人成视频| 免费无码成人av在线播放不卡| 日本污ww视频网站| 国产麻豆剧传媒精品av| 日韩乱码在线观看免费视频网站| 国产丰满人妻一区二区| 国产成人无码区免费网站| 天堂资源中文网| 免费人成在线视频无码| 好男人社区影院www| 永久免费看mv网站入口亚洲| www国产亚洲精品久久| 成人av一本不卡二卡| 欧美又大又硬又粗bbbbb| 性欧美牲交在线视频| 成年女人午夜性视频| 亚洲成av人片一区二区梦乃| 夜夜躁狠狠躁2021|