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  4. Recombinant Mouse PTB-containing, cubilin and LRP1-interacting protein (Pid1)

Recombinant Mouse PTB-containing, cubilin and LRP1-interacting protein (Pid1)

  • 中文名稱：
    小鼠Pid1重組蛋白
  • 貨號：
    CSB-YP668864MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pid1重組蛋白
  • 貨號：
    CSB-EP668864MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pid1重組蛋白
  • 貨號：
    CSB-EP668864MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pid1重組蛋白
  • 貨號：
    CSB-BP668864MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pid1重組蛋白
  • 貨號：
    CSB-MP668864MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pid1
  • Uniprot No.：
  • 別名：
    Pid1; Pcli1; PTB-containing; cubilin and LRP1-interacting protein; P-CLI1; Phosphotyrosine interaction domain-containing protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-217
  • 氨基酸序列
    MWQPATERLQ HFQTMLKSKL NVLTLKKEPI PAVLFHEPEA IELCTTTPLM KARTHSGCKV TYLGKVSTTG MQFLSGCTEK PVIELWKKHT LAREDVFPAN ALLEIRPFQV WLHHLDHKGE ATVHMDTFQV ARIAYCTADH NVSPNIFAWV YREINDDLSY QMDCHAVQCE SKLEAKKLAH AMMEAFKKTF HSMKSDGRIH RSSSSEEASQ ELESDDG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Increases proliferation of preadipocytes without affecting adipocytic differentiation.
  • 基因功能參考文獻：
    1. Results thus indicate phosphotyrosine interaction domain containing 1 (PID1) as a critical regulator of glucose metabolism in adipocytes. PMID: 29391195
    2. data demonstrate that differentially methylated genes are significantly overrepresented in NYGGF4-overexpression adipocytes, providing valuable clues for further exploration of the role of NYGGF4 in insulin sensitivity regulation. PMID: 23443082
    3. These results suggested that addition of silencing NYGGF4 partly rescued the effect of insulin resistance and mitochondrial dysfunction in NYGGF4 silenced 3T3-L1 adipocytes incubated with cyanide p-trifluoromethoxyphenyl-hydrazone. PMID: 23085536
    4. Data demonstrate that NYGGF4 knockdown increases glucose transport in myocytes by activation of the IRS-1/PI3K/AKT insulin pathway. PMID: 22528394
    5. Lipoic acid protects 3T3-L1 adipocytes from NYGGF4-induced IR partially through increasing phosphorylation of IRS-1 and Akt PMID: 22528396
    6. NYGGF4 reduced intracellular ATP concentration and promoted an increase in mitochondrial transmembrane potential and reactive oxygen species level without affecting mitochondrial morphology or mtDNA. PMID: 21080215
    7. The expression of NYGGF4 mRNA is affected by a variety of factors that are related to insulin sensitivity.[NYGGF4] PMID: 19894142

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  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：


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