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  4. Recombinant Mouse Otopetrin-1 (Otop1), partial

Recombinant Mouse Otopetrin-1 (Otop1), partial

  • 中文名稱：
    小鼠Otop1重組蛋白
  • 貨號：
    CSB-YP772148MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Otop1重組蛋白
  • 貨號：
    CSB-EP772148MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Otop1重組蛋白
  • 貨號：
    CSB-EP772148MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Otop1重組蛋白
  • 貨號：
    CSB-BP772148MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Otop1重組蛋白
  • 貨號：
    CSB-MP772148MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Otop1
  • Uniprot No.：
  • 別名：
    Otop1; Proton channel OTOP1; Otopetrin-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction.
  • 基因功能參考文獻：
    1. Otop1 defines a unique target of cytokine signaling that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. PMID: 24379350
    2. Data show that tlt and mlh mutations uncouple Otopetrin 1 from inhibition of P2Y receptor function. PMID: 21236346
    3. OTOP1 is expressed at the apex of supporting cells. It increases cytosolic Ca in response to purinergic agonists by blocking mobilization of Ca from intracellular stores in an extracellular Ca-dependent manner & by mediating extracellular Ca influx. PMID: 20554841
    4. a non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice is caused by mutations in otopetrin 1 PMID: 12651873
    5. Otopetrin 1 encodes a multi-transmembrane domain protein expressed in the developing otocyst. Mouse mutants tilted and mergulhador carry recessive mutations in Otop1 that result in otoconial agenesis without causing collateral deafness. PMID: 12651873

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Otopetrin family
  • 組織特異性：
    Detected in embryonic inner ear macular epithelia. Expressed in thymus, heart, kidney, skin, vestibular system of the inner ear, sour taste cells, brown adipose tissue, heart, uterus, dorsal root ganglion, adrenal gland, lactating mammary gland and stimul
  • 數據庫鏈接：


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