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  4. Recombinant Mouse Nyctalopin (Nyx)

Recombinant Mouse Nyctalopin (Nyx)

  • 中文名稱：
    小鼠Nyx重組蛋白
  • 貨號：
    CSB-YP016237MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nyx重組蛋白
  • 貨號：
    CSB-EP016237MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nyx重組蛋白
  • 貨號：
    CSB-EP016237MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nyx重組蛋白
  • 貨號：
    CSB-BP016237MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nyx重組蛋白
  • 貨號：
    CSB-MP016237MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nyx
  • Uniprot No.：
  • 別名：
    Nyx; Nyctalopin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    19-476
  • 氨基酸序列
    TE ACLRACPAAC TCSHVERGCS VRCDRAGLQR VPQEFPCEAA SIDLDRNGLR ILGERAFGTL PSLRRLSLRH NNLSFITPGA FKGLPRLAEL RLAHNGELRY LHVRTFAALG RLRRLDLAAC RLFSVPERLL AELPALRELT AFDNLFRRVP GALRGLANLT HAHFERSRIE AVASGSLLGM RRLRSLSLQA NRVRAVHAGA FGDCGALEDL LLNDNLLATL PAAAFRGLRR LRTLNLGGNA LGSVARAWFS DLAELELLYL DRNSITFVEE GAFQNLSGLL ALHLNGNRLT VLSWAAFQPG FFLGRLFLFR NPWRCDCQLE WLRDWMEGSG RVADVACASP GSVAGQDLSQ VVFERSSDGL CVDPDELNFT TSSPGPSPEP VATTVSRFSS LLSKLLAPRA PVEEVANTTW ELVNVSLNDS FRSHAVMVFC YKATFLFTSC VLLSLAQYVV VGLQRE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. murine nyctalopin is anchored to the plasma membrane by a single transmembrane domain, such that the leucin-rich repeat domain is located in the extracellular space. PMID: 22485138
    2. The results of this study suggested that the nyctalopin is acting as an accessory TRP channel subunit critical for proper channel localization to the synapse. PMID: 21734298
    3. The nob phenotype is caused by an 85-bp deletion in the mouse nyx gene, which encodes the nyctalopin protein. PMID: 12506099
    4. These data suggest an important function of the Nyx protein in the inner retina and provide evidence that CSNB1 is based on a defect in the inner retinal circuitry. PMID: 12714669
    5. Human and mouse nyctalopin are membrane-bound extracellular proteins and are functionally conserved. PMID: 14507859
    6. Absence of nyctalopin does not disrupt the expression pattern of other proteins known to be required for synaptic transmission. PMID: 14570248
    7. No differences in nob mice and carriers suggesting equal susceptibility to light-induced photoreceptor degeneration. PMID: 15180280

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  • 相關疾?。?/div>
    Defects in Nyx are the cause of the nob (no b-wave) phenotype which is characterized by a decreased sensitivity to light and an absence of the rod b-wave in electroretinograms. An 85-bp deletion in exon 3 results in the loss of 288 residues from the C-terminus of the protein.
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily
  • 組織特異性：
    Expressed abundantly in retina with lower levels in brain, lung, spleen and testis. Not detected in kidney, heart or liver. In the retina, highest expression found in the inner nuclear layer and ganglion cell layer.
  • 數據庫鏈接：


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