在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Norrin (Ndp)

Recombinant Mouse Norrin (Ndp)

  • 中文名稱：
    小鼠Ndp重組蛋白
  • 貨號：
    CSB-YP015609MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ndp重組蛋白
  • 貨號：
    CSB-EP015609MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ndp重組蛋白
  • 貨號：
    CSB-EP015609MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ndp重組蛋白
  • 貨號：
    CSB-BP015609MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ndp重組蛋白
  • 貨號：
    CSB-MP015609MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ndp
  • Uniprot No.：
  • 別名：
    Ndp; NdphNorrin; Norrie disease protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    25-131
  • 氨基酸序列
    KTDSSF LMDSQRCMRH HYVDSISHPL YKCSSKMVLL ARCEGHCSQA SRSEPLVSFS TVLKQPFRSS CHCCRPQTSK LKALRLRCSG GMRLTATYRY ILSCHCEECS S
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
  • 基因功能參考文獻：
    1. NORRIN presented to FZD4 further increases cardiomyocyte output via proliferation through the canonical WNT pathway. PMID: 29249665
    2. NDP is a potent trigger of FZD4 ubiquitination and induces internalization of the NDP receptor complex into the endo-lysosomal compartment. Inhibition of ubiquitinated cargo transport strongly impairs NDP/FZD4 signalling in vitro and recapitulates CNS angiogenesis and blood-CNS-barrier defects caused by impaired vascular beta-catenin signalling in mice. PMID: 28675177
    3. results provide functional and biochemical dissection of Fzd4 in Norrin signaling. PMID: 30104375
    4. The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4-Wnt signaling during gonadal development. PMID: 25188337
    5. Multi-functional norrin is a ligand for the LGR4 receptor. PMID: 23444378
    6. In this study we demonstrate, for the first time, that Norrin protein is expressed along the retinal blood vessels. PMID: 23206555
    7. Taken together, we have uncovered a cell autonomous function for Ndp in retinal progenitor proliferation that is independent of its function in the retinal vasculature, which could explain the neural defects associated with Norrie disease PMID: 23201751
    8. We conclude that constitutive overexpression of Norrin protects photoreceptors from light damage, an effect that is mediated by Wnt/beta-catenin and EDN2 signaling and involves neurotrophic activities of BDNF. PMID: 23009755
    9. The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state. PMID: 23217714
    10. Results suggest that the delayed outgrowth of the SRVP and decreased angiogenic sprouting in Norrin knockout (Ndp(y/-)) mice are direct effects of the reduced proliferation of endothelial cells from the superficial retinal vascular plexus (SRVP). PMID: 22394677
    11. Norrin has a neuroprotective role for retinal neurons independent from its role on the growth of retinal capillaries. PMID: 22183393
    12. These observations suggest the possibility that Norrin may have developmental and/or homeostatic functions beyond the retina and cochlea. PMID: 21055480
    13. Norrin has pronounced neuroprotective properties on retinal neurons. The effects of Norrin involve activation of Wnt/beta-catenin signaling and subsequent induction of neurotrophic growth factors in Muller cells. PMID: 20427659
    14. a Norrin-Fz4 signaling system plays a central role in vascular development in the eye and ear, and ligands unrelated to Wnts can act through Fz receptors PMID: 15035989
    15. Transgenic expression of ectopic norrin under control of a lens-specific promoter restores the formation of a normal retinal vascular network in Ndp(y/-) mutant mice. PMID: 15716406
    16. These data provide strong evidence for Norrin playing an important role in female reproductive tissues. PMID: 16035034
    17. This provides the first description of a brain phenotype in Ndph knockout mice, which will help to elucidate the role of Norrin in the brain. PMID: 18547247
    18. These data provide molecular evidence for a role of Norrin in the development of the retinal vasculature. PMID: 18978344
    19. Data indicate that Norrin multimers and TSPAN12 cooperatively promote multimerization of FZD4 and its associated proteins to elicit physiological levels of signaling. PMID: 19837033

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:17986

    STRING: 10090.ENSMUSP00000046692

    UniGene: Mm.5014



主站蜘蛛池模板： 中文人妻av久久人妻18| 亚洲精品中文字幕乱码三区| 久久国产精品精品国产色婷婷| 久久无码专区国产精品s| 免费观看性行为视频的网站 | 亚洲精品鲁一鲁一区二区三区| 乱子伦视频在线看| 99蜜桃臀久久久欧美精品网站| 国产成人精品午夜福利在线播放| 精品国内综合一区二区| 色哟哟最新在线观看入口| 中文字幕乱码免费| 特黄大片又粗又大又暴| 妺妺窝人体色777777| 最近中文字幕免费大全在线| 亚洲人成无码网站在线观看| 亚洲成a人片在线观看无码专区| 久久久精品国产sm调教网站| 青青草国产精品欧美成人| 国产在线乱子伦一区二区| 人妻少妇精品无码专区动漫| 丝袜老师办公室里做好紧好爽| 国产免费又色又爽又黄软件| 久久久国产乱子伦精品| 国产专区国产av| 精品视频无码一区二区三区| 青青青国产在线观看资源| 亚洲人精品亚洲人成在线 | av在线播放无码线| 久久久精品欧美一区二区免费| 七月丁香五月婷婷首页| 好男人在线社区www在线影院 | 99久久综合狠狠综合久久| 日本熟妇人妻xxxxx-欢迎您| 精品国产天堂综合一区在线| 五月丁香啪啪| 中国xxxx做受视频| 国产精品亚洲а∨天堂| 国产精品无码天天爽视频| 无码免费毛片手机在线无卡顿| 一本久道久久综合狠狠老|