在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Non-homologous end-joining factor 1 (Nhej1)

Recombinant Mouse Non-homologous end-joining factor 1 (Nhej1)

  • 中文名稱：
    小鼠Nhej1重組蛋白
  • 貨號：
    CSB-YP662047MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nhej1重組蛋白
  • 貨號：
    CSB-EP662047MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nhej1重組蛋白
  • 貨號：
    CSB-EP662047MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nhej1重組蛋白
  • 貨號：
    CSB-BP662047MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nhej1重組蛋白
  • 貨號：
    CSB-MP662047MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nhej1
  • Uniprot No.：
  • 別名：
    Nhej1; Xlf; Non-homologous end-joining factor 1; Protein cernunnos; XRCC4-like factor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-295
  • 氨基酸序列
    MEELEQDLLL QPWAWLQLAE NSLLAKVSIT KHGYALLISD LQQVWHEQVD TSVVSQRAKE LNKRLTAPPA ALLCHLDEAL RPLFKDSAHP SKATFSCDRG EEGLILRVQS ELSGLPFSWH FHCIPASSSL VSQHLIHPLM GVSLALQSHV RELAALLRMK DLEIQAYQES GAVLSRSRLK TEPFEENSFL EQFMAEKLPE ACAVGDGKPF AMSLQSLYVA VTKQQIQARQ AHKDSGETQA SSSTSPRGTD NQPEEPVSLS STLSEPEYEP VAASGPMHRA RLVKSKRKKP RGLFS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends. Interacts with POLL (DNA polymerase lambda); promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary. Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired. The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other. The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors. Binds DNA in a length-dependent manner.
  • 基因功能參考文獻：
    1. we also find that PAXX deficiency has no impact on V(D)J recombination DSB joining in ATM-deficient pro-B lines. We discuss implications of these findings with respect to potential PAXX and XLF functions in C-NHEJ. PMID: 27601633
    2. Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ)). PMID: 28759779
    3. XLF has an important role during V(D)J recombination. PMID: 27281794
    4. PAXX and XLF proteins may have redundant functions during Non-homologous end joining. PMID: 27830975
    5. Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis PMID: 27798842
    6. These results reveal an unanticipated functional interplay between the RAG complex and XLF in repairing RAG-induced DNA breaks and maintaining genome integrity during antigen receptor gene assembly. PMID: 26833222
    7. XLF-deficient mice recapitulate the age-dependent lymphocytopenia of patients. PMID: 25075129
    8. XLF functionally overlaps with DNA-PKcs in normal development, promotion of genomic stability in fibroblasts, and in IgH class switch recombination in mature B cells. PMID: 23345432
    9. Cernunnos deficiency results in chronic activation of the DNA damage response, P53-driven upregulation of proapoptotic factors, leading to decreased thymocyte viability and a qualitative alteration of the T cell repertoire in both humans and mice. PMID: 23207905
    10. XLF repair protein and 53BP1 DNA damage response factor have overlapping functions in end joining and lymphocyte development PMID: 22355127
    11. find that combined XLF/53BP1 deficiency in mice severely impairs C-NHEJ, V(D)J recombination, and lymphocyte development while also leading to general genomic instability and growth defects PMID: 22308489
    12. XLF, ATM and H2AX all have fundamental roles in processing and joining DNA ends during V(D)J recombination, but that these roles have been masked by unanticipated functional redundancies PMID: 21160472
    13. in mice, Cernunnos-XLF is essential for normal NHEJ-mediated repair of DNA DSBs and the Cernunnos-XLF acts as a genomic caretaker to prevent genomic instability PMID: 17360556

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    XLF family
  • 數據庫鏈接：


主站蜘蛛池模板： 国产毛片久久久久久国产毛片| 国产精品星空无限传媒| 亚洲精品综合欧美一区二区三区 | 97精品久久久久中文字幕| 成人毛片无码免费播放网站| 丁香五月开心婷婷激情综合| 精品免费看国产一区二区| 亚洲成av人片在线观看天堂无码| 97超级碰碰人妻中文字幕 | 国产精品久久久久久影视不卡| 国产丶欧美丶日本不卡视频| 女人色极品影院| 久久久久久久精品成人执小说一白| 国产成人精品免费午夜app| 99久久99久久精品国产片果冻| 日本丰满熟妇bbxbbxhd| 亚洲精品无码久久毛片波多野吉衣| 国产新婚夫妇叫床声不断| 久久这里只有精品首页| 欧洲精品欧美精品| 日韩欧美亚洲综合久久影院ds| 早起邻居人妻奶罩太松av| 亚洲 欧美日韩 综合 国产| 人妻熟女 视频二区 视频一区| 色欲天天天无码视频| 亚洲人成色77777在线观看| 黑人大荫蒂高潮视频| 日本看片一二三区高清| 正在播放国产剧情亂倫| 欧美又大又硬又粗bbbbb| 国产高清japanese在线播放e| 国产成 人 综合 亚洲| 国产又粗又猛又爽又黄| 亚洲国产精品国自产拍av| 久久人妻国产精品| 国产免费午夜a无码v视频| 国产精品美女久久久久久久 | 国产高清成人免费视频在线观看| 18禁勿入午夜网站入口| 97久久人人超碰国产精品| 国产国产乱老熟女视频网站97 |