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  4. Recombinant Mouse Nocturnin (Ccrn4l)

Recombinant Mouse Nocturnin (Ccrn4l)

  • 中文名稱：
    小鼠Noct重組蛋白
  • 貨號：
    CSB-YP004853MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Noct重組蛋白
  • 貨號：
    CSB-EP004853MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Noct重組蛋白
  • 貨號：
    CSB-EP004853MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Noct重組蛋白
  • 貨號：
    CSB-BP004853MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Noct重組蛋白
  • 貨號：
    CSB-MP004853MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Noct
  • Uniprot No.：
  • 別名：
    Noct; Ccr4; Ccrn4l; NocNocturnin; EC 3.1.3.-; Carbon catabolite repression 4-like protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-429
  • 氨基酸序列
    MYQSPRRLCS ALLLRDAPGL RRTLVPGPRR TLAPPVLGSR PKSPQLQAAA ASGAARSRPR TVSSMGNGTS RLYSALAKTV NSSAAAQHPE YLVSTDPEHL EPIDPKELLE ECRAVLHTRP PRYQRDFVDL RTDCSSSHSP IRVMQWNILA QALGEGKDNF VQCPVEALKW EERKCLILEE ILAYQPDILC LQEVDHYFDT FQPLLSRLGY QGTFFPKPWS PCLDVEHNNG PDGCALFFLQ NRFKLISSTN IRLTAMTLKT NQVAIAQTLE CKESGRQFCI AVTHLKARTG WERFRSAQGC DLLQNLQNIT QGAKIPLIVC GDFNAEPTEE VYKHFASSSL NLNSAYKLLS PDGQSEPPYT TWKIRTSGEC RHTLDYIWYS RHALSVTSAL DLLTEEQIGP NRLPSFHYPS DHLSLVCDFS FNEEPHELF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos.
  • 基因功能參考文獻：
    1. Data suggest that Nocturnin (NOC) exerts strong effects on physiology through direct and indirect control of target mRNAs. PMID: 26586468
    2. precise expression of nocturnin is critical to proper development of early mouse embryos PMID: 23449310
    3. Nocturnin plays a role in linking nutrient sensing by the circadian clock to lipid mobilization in the adipocytes PMID: 21347334
    4. data suggest that Nocturnin has a novel stabilizing activity that plays an important role in the circadian response to inflammatory signals PMID: 22073225
    5. Loss of nocturnin enhances bone formation; the circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate. PMID: 22082366
    6. Data suggest that nocturnin plays an important role in the trafficking of dietary lipid in the intestinal enterocytes by optimizing efficient absorption of lipids. PMID: 21820310
    7. Noc interacts with Igf1 in a strain- and tissue-specific manner and reduces Igf1 expression by targeting the longer form of the Igf1 3'UTR. PMID: 20685873
    8. Noc plays a unique role in the regulation of mesenchymal stem-cell lineage allocation by modulating PPAR-gamma activity through nuclear translocation. PMID: 20498072
    9. Nocturnin, is markedly upregulated with Pparg activation in adipocytes and bone marrow stromal cells. PMID: 20392228
    10. nocturnin exhibits circadian rhythmicity of mRNA abundance with peak levels at the time of light offset in the retina, spleen, heart, kidney and liver. PMID: 11394964
    11. circadian expression in the liver and retina PMID: 12031487
    12. Nocturnin expression can be regulated by extracellular stimuli, it can respond directly and specifically to physiological cues PMID: 17400819
    13. Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. PMID: 17517647
    14. A similar protein in Xenopus laevis was shown to be a deadenylase (mRNA poly A ribonuclease). PMID: 12573214

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Mitochondrion.
  • 蛋白家族：
    CCR4/nocturin family
  • 組織特異性：
    Highly expressed in the differentiated adipocyte (at protein level). Ubiquitous.
  • 數據庫鏈接：


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