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Recombinant Mouse Nicotinamide riboside kinase 1 (Nrk1)

In Stock
  • 中文名稱:
    小鼠Nrk1重組蛋白
  • 貨號:
    CSB-EP835569MO
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Nrk1
  • Uniprot No.:
  • 別名:
    NRK 1;NmR-K 1;Nicotinic acid riboside kinase 1;Ribosylnicotinamide kinase 1;RNK 1;Ribosylnicotinic acid kinase 1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    26.4 kDa
  • 表達區域:
    1-195aa
  • 氨基酸序列
    MKRFVIGIGGVTNGGKTTLAKSLQKHLPNCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWMENPGSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEPPDPPGYFDGHVWPMYLKHRQEMSSITWDIVYLDGTRSEEDLFSQVYEDVKQELEKQNGL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
  • 基因功能參考文獻:
    1. NRK1 KO myotubes revealed redundancy in the NRK1/2 dependent metabolism of nicotinamide riboside to NAD+. PMID: 28752046
    2. adenoviral delivery of NRK1 in diet- and age-induced mice elevates hepatic NAD(+) levels, reduces hepatic steatosis, and improves glucose tolerance and insulin sensitivity. PMID: 29678570
    3. nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous nicotinamide riboside and nicotinamide mononucleotide for NAD(+) synthesis. PMID: 27725675
  • 蛋白家族:
    Uridine kinase family, NRK subfamily
  • 數據庫鏈接:


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