在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Nicotinamide N-methyltransferase (Nnmt)

Recombinant Mouse Nicotinamide N-methyltransferase (Nnmt)

  • 中文名稱：
    小鼠Nnmt重組蛋白
  • 貨號：
    CSB-YP015906MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nnmt重組蛋白
  • 貨號：
    CSB-EP015906MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nnmt重組蛋白
  • 貨號：
    CSB-EP015906MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nnmt重組蛋白
  • 貨號：
    CSB-BP015906MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nnmt重組蛋白
  • 貨號：
    CSB-MP015906MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nnmt
  • Uniprot No.：
  • 別名：
    NnmtNicotinamide N-methyltransferase; EC 2.1.1.1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-264
  • 氨基酸序列
    MESGFTSKDT YLSHFNPRDY LEKYYSFGSR HCAENEILRH LLKNLFKIFC LGAVKGELLI DIGSGPTIYQ LLSACESFTE IIVSDYTDQN LWELQKWLKK EPGAFDWSPV VTYVCDLEGN RMKGPEKEEK LRRAIKQVLK CDVTQSQPLG GVSLPPADCL LSTLCLDAAC PDLPAYRTAL RNLGSLLKPG GFLVMVDALK SSYYMIGEQK FSSLPLGWET VRDAVEEAGY TIEQFEVISQ NYSSTTSNNE GLFSLVGRKP GRSE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway. Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase. Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification.
  • 基因功能參考文獻：
    1. Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide have been presented. PMID: 28720493
    2. NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes PMID: 24717514
    3. Brain NNMT expression was not altered in hyperhomocysteinemia. PMID: 21169389
    4. Adipose tissue is a source of nicotinamide N-methyltransferase and homocysteine. PMID: 18996527
    5. the progression of vascular inflammation and atherosclerosis was associated with the upregulation of hepatic nicotinamide N-methyltransferase activity and subsequent increase in endogenous MNA plasma levels PMID: 19307695

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
  • 組織特異性：
    Expressed in white adipose tissue and liver (at protein level).
  • 數據庫鏈接：


主站蜘蛛池模板： 日韩av在线观看免费| 新区乱码无人区二精东| 亚洲综合色区另类小说 | 无码熟妇人妻av在线影片最多| 国产精品女主播在线视频| 日韩av无码中文字幕| 亚洲男人的天堂在线va| 国产片a国产片免费看视频| 中文字幕在线不卡精品视频99 | 极品少妇伦理一区二区| 成人试看120秒体验区| 亚洲国产一区二区三区波多野结衣| 丰满爆乳无码一区二区三区| 午夜高清在线无码| 日韩高清成片免费视频| 国产拍揄自揄免费观看| 青草青草视频2免费观看| 黑人巨茎美女高潮视频| 俄罗斯美女真人性做爰| 在线看片无码永久免费视频| 国产无套水多在线观看| 国产精品久久久久久熟妇吹潮软件 | 久天啪天天久久99久久| 又黄又爽又色的免费网站| 夜夜夜夜猛噜噜噜噜噜| 亚洲欧美日韩国产精品一区二区| 熟女俱乐部五十路六十路av| 亚洲最新版av无码中文字幕| 男女啪啦啦超猛烈动态图| 五月天中文字幕mv在线| 无码夜色一区二区三区| 男女啪啪做爰高潮免费网站| 大陆国产乱人伦| 国产日产高清欧美一区| 成人毛片100部免费看| 人人妻人人妻人人片av| 国产丝袜在线精品丝袜不卡| 久久被窝亚洲精品爽爽爽| 欧美日韩亚洲精品瑜伽裤| 小嫩妇好紧好爽再快视频| 国产在线拍揄自揄视频网试看|