Recombinant Mouse Neurotrypsin (Prss12)

中文名稱：

小鼠Prss12重組蛋白
貨號：

CSB-YP018812MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Prss12重組蛋白
貨號：

CSB-EP018812MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Prss12重組蛋白
貨號：

CSB-EP018812MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Prss12重組蛋白
貨號：

CSB-BP018812MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Prss12重組蛋白
貨號：

CSB-MP018812MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Prss12
Uniprot No.：

O08762
別名：

Prss12; Bssp3; Neurotrypsin; EC 3.4.21.-; Brain-specific serine protease 3; BSSP-3; Motopsin; Serine protease 12
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

22-761
氨基酸序列

DPVSRSPLH RPHPSPPRSQ HAHYLPSSRR PPRTPRFPLP LRIPAAQRPQ VLSTGHTPPT IPRRCGAGES WGNATNLGVP CLHWDEVPPF LERSPPASWA ELRGQPHNFC RSPDGSGRPW CFYRNAQGKV DWGYCDCGQG PALPVIRLVG GNSGHEGRVE LYHAGQWGTI CDDQWDNADA DVICRQLGLS GIAKAWHQAH FGEGSGPILL DEVRCTGNEL SIEQCPKSSW GEHNCGHKED AGVSCVPLTD GVIRLAGGKS THEGRLEVYY KGQWGTVCDD GWTEMNTYVA CRLLGFKYGK QSSVNHFDGS NRPIWLDDVS CSGKEVSFIQ CSRRQWGRHD CSHREDVGLT CYPDSDGHRL SPGFPIRLVD GENKKEGRVE VFVNGQWGTI CDDGWTDKHA AVICRQLGYK GPARARTMAY FGEGKGPIHM DNVKCTGNEK ALADCVKQDI GRHNCRHSED AGVICDYLEK KASSSGNKEM LSSGCGLRLL HRRQKRIIGG NNSLRGAWPW QASLRLRSAH GDGRLLCGAT LLSSCWVLTA AHCFKRYGNN SRSYAVRVGD YHTLVPEEFE QEIGVQQIVI HRNYRPDRSD YDIALVRLQG PGEQCARLST HVLPACLPLW RERPQKTASN CHITGWGDTG RAYSRTLQQA AVPLLPKRFC KERYKGLFTG RMLCAGNLQE DNRVDSCQGD SGGPLMCEKP DESWVVYGVT SWGYGCGVKD TPGVYTRVPA FVPWIKSVTS L
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
基因功能參考文獻：
1. This study identifies Tequila and neurotrypsin as new genes repressed by presenilins and reveals a novel mechanism used by presenilins to modulate CREB signaling based on controlling CREB recruitment. PMID: 24145027
2. co-expression of sez-6 with motopsin restored the effect of motopsin at the basal level, while sez-6 expression alone showed no effects on cell morphology. Our results suggest that the interaction of motopsin and sez-6 modulates neuronal cell morphology PMID: 23770366
3. Our results indicate that an extracellular protease, motopsin, preferentially affects social behaviors, and modulates the functions of hippocampal neurons. PMID: 20092579
4. motopsin has multiple functions, such as axon outgrowth, arranging perineuronal environment, and maintaining neuronal plasticity, partly in coordination with other proteases including tissue plasminogen activator. PMID: 17223089
5. neurotrypsin exclusively cleaves glycanated variants of agrin; neurotrypsin-dependent cleavage of agrin was concentrated at synapses, where the most heavily glycanated variants of agrin predominate PMID: 18230682
6. Detailed analyses indicated that presynaptic action potential firing is necessary for the release of neurotrypsin, whereas postsynaptic NMDA receptor activation is necessary for the neurotrypsin-dependent cleavage of agrin. PMID: 19303856
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亞細胞定位：

Secreted.
蛋白家族：

Peptidase S1 family
組織特異性：

Most abundant in cerebral cortex, hippocampus and amygdala.
數據庫鏈接：

KEGG: mmu:19142

STRING: 10090.ENSMUSP00000029603

UniGene: Mm.9431