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  4. Recombinant Mouse Neurocan core protein (Ncan), partial

Recombinant Mouse Neurocan core protein (Ncan), partial

  • 中文名稱：
    小鼠Ncan重組蛋白
  • 貨號：
    CSB-YP015513MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ncan重組蛋白
  • 貨號：
    CSB-EP015513MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ncan重組蛋白
  • 貨號：
    CSB-EP015513MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ncan重組蛋白
  • 貨號：
    CSB-BP015513MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ncan重組蛋白
  • 貨號：
    CSB-MP015513MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ncan
  • Uniprot No.：
  • 別名：
    Ncan; Cspg3; Neurocan core protein; Chondroitin sulfate proteoglycan 3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
  • 基因功能參考文獻：
    1. The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack neurocan, the informational content stored by synaptic plasticity is not the same. PMID: 28512860
    2. Study shows the viability and proliferation of astrocytes are significantly increased by beta-amyloid in a dose dependent manner. Moreover, beta-amyloid may effectively up-regulate the neurocan expression via regulating Sox9. PMID: 27317830
    3. This study provided evidence that the neurocan modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs. PMID: 23637166
    4. Traumatic brain injury results in an increase in the chondroitin glycosaminoglycans (CSPGs) neurocan and NG2 expression in a tight band surrounding the injury core. PMID: 22628090
    5. Ncan -/- mice showed behavioral abnormalities that were strikingly similar to those of the human mania phenotype. PMID: 22952076
    6. neurocan contributes to the molecular heterogeneity of the perinodal matrix, and its nodal expression is dependent on Bral1. PMID: 21566336
    7. this shows a heterophilic molecular interaction between cell adhesion molecular L1 and neurocan is involved in determining the thalamocortical pathway within the neocortical anlage PMID: 16324103
    8. PTPsigma binds with high affinity to neural chondroitin sulfate proteoglycans(CPSGs); binding involves chondroitin sulfate chains & a specific site on 1st immunoglobulin-like domain of PTPsigma; results indicate PTPsigma can act as a receptor for CSPGs PMID: 19833921

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Aggrecan/versican proteoglycan family
  • 組織特異性：
    Brain.
  • 數據庫鏈接：


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