在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Netrin receptor UNC5C (Unc5c), partial

  • 中文名稱:
    小鼠Unc5c重組蛋白
  • 貨號:
    CSB-YP025630MO
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Unc5c重組蛋白
  • 貨號:
    CSB-EP025630MO
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Unc5c重組蛋白
  • 貨號:
    CSB-EP025630MO-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Unc5c重組蛋白
  • 貨號:
    CSB-BP025630MO
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Unc5c重組蛋白
  • 貨號:
    CSB-MP025630MO
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Unc5c
  • Uniprot No.:
  • 別名:
    Unc5c; Rcm; Unc5h3; Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; Rostral cerebellar malformation protein
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
  • 基因功能參考文獻(xiàn):
    1. UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage. PMID: 26147436
    2. UNC5c expression is enriched in CA3 hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells. PMID: 25419706
    3. Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. PMID: 24739528
    4. unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc haploinsufficiency and is observed after adolescence. PMID: 23738838
    5. this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain. PMID: 21307253
    6. Our results provide the first evidence that genes involved in netrin signaling are necessary for proper mammalian spinal motor axon development and trochlear axon guidance. PMID: 16723533
    7. These results support an important role for UNC5C in spinal accessory motor neuron development. PMID: 17543537
    8. repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis PMID: 18077458
    9. The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway. PMID: 18184911

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Defects in Unc5c are the cause of rostral cerebellar malformation (Rcm). Rcm is characterized by cerebellar and midbrain defects, apparently as a result of abnormal neuronal migration.
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell surface. Cell junction, synapse, synaptosome. Cell projection, dendrite. Cell projection, axon. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.
  • 蛋白家族:
    Unc-5 family
  • 組織特異性:
    Expressed in cortical and cerebellar neurons, including cells of the external and internal granular layer and of the Purkinje cell layer (at protein level). Mainly expressed in regions of differentiating neurons. Highly expressed in brain and lung. Expres
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 日韩成人无码毛片一区二区| 亚洲精品国产a久久久久久| 性乌克兰xxxx极品| 久久婷婷色香五月综合缴缴情 | 东京热无码一区二区三区av| 亚洲国产欧美在线人成aaaa| 色狠狠成人综合网| 国产乱子经典视频在线观看| 国产成人国拍亚洲精品| 欧美 日韩 亚洲 精品二区| 色老板精品视频在线观看| 久久亚洲一区二区三区四区五区| 欧美肥老太牲交| 国产亚洲综合区成人国产系列| 国产人妻精品久久久久野外| 国产精品多p对白交换绿帽| 国产欧色美视频综合二区| 手机国产乱子伦精品视频| 国产丰满麻豆videossexhd| 亚洲妇女行蜜桃av网网站| 免费国产黄网站在线观看可以下载| 国产成人无码精品久久久露脸| 日本大乳高潮视频在线观看| 亚洲国产v高清在线观看| 日本真人边吃奶边做爽电影| 秋霞特色aa大片| 欧美一区二区三区视频在线观看| 综合欧美亚洲日本一区| 中文字幕资源网| 人人妻人人爽人人做夜欢视频| 精品少妇人妻av久久久| 人妻无码中字在线a| 综合网日日天干夜夜久久| 亚洲熟女精品中文字幕| 国内精品久久久久久久久电影网| 亚洲中文字幕无码中文| 亚洲人成电影网站在线观看| 色综合久久精品亚洲国产| 老司机导航亚洲精品导航| 国产真人作爱免费视频道歉| 美女脱了内裤张开腿让男人桶网站|