在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Nephronectin (Npnt)

Recombinant Mouse Nephronectin (Npnt)

  • 中文名稱：
    小鼠Npnt重組蛋白
  • 貨號：
    CSB-YP016019MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Npnt重組蛋白
  • 貨號：
    CSB-EP016019MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Npnt重組蛋白
  • 貨號：
    CSB-EP016019MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Npnt重組蛋白
  • 貨號：
    CSB-BP016019MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Npnt重組蛋白
  • 貨號：
    CSB-MP016019MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Npnt
  • Uniprot No.：
  • 別名：
    Npnt; Neph1; Poem; Nephronectin; Preosteoblast EGF-like repeat protein with MAM domain
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    20-561
  • 氨基酸序列
    D FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC QPQCKHGECV GPNKCKCHPG FAGKTCNQDL NECGLKPRPC KHRCMNTFGS YKCYCLNGYM LLPDGSCSSA LSCSMANCQY GCDVVKGQVR CQCPSPGLQL APDGRTCVDI DECATGRVSC PRFRQCVNTF GSYICKCHTG FDLMYIGGKY QCHDIDECSL GQHQCSSYAR CYNIHGSYKC QCRDGYEGDG LNCVYIPKVM IEPSGPIHMP ERNGTISKGD GGHANRIPDA GSTRWPLKTP YIPPVITNRP TSKPTTRPTP NPTPQPTPPP PPPLPTEPRT TPLPPTPERP STRPTTIAPA TSTTTRVITV DNRIQTDPQK PRGDVFIPRQ PTNDLFEIFE IERGVSADEE VKDDPGILIH SCNFDHGLCG WIREKDSDLH WETARDPAGG QYLTVSAAKA PGGKAARLVL RLGHLMHSGD LCLSFRHKVT GLHSGTLQVF VRKHGTHGAA LWGRNGGHGW RQTQITLRGA DVKSVIFKGE KRRGHTGEIG LDDVSLKRGR C
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
  • 基因功能參考文獻：
    1. Results show that Npnt is highly expressed in tooth germ, and localized in the basement membrane between dental epithelium and mesenchyme. The study indicates that Npnt plays a critical scaffold role in dental epithelial stem cell differentiation and proliferation, and regulates Sox2 expression during tooth development. PMID: 28345658
    2. Low Nephronectin expression is associated with Metastatic Breast Carcinoma. PMID: 28842827
    3. NPNT stimulates the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated kinase (MAPK) in endothelial cells. NPNT is a paracrine angiogenic factor and may play a role in pathological osteoporosis. PMID: 27782206
    4. These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt gene expression PMID: 28093227
    5. we found that bone morphogenic protein-2 (BMP-2), known as an osteogenesis inducing cytokine, strongly up-regulated the expression of Npnt mRNA in a murine skeletal muscle cell line (C2C12) via the BMP-SMAD signaling pathway PMID: 27374296
    6. Nephronectin is capable of binding to heparan sulfate proteoglycans in basement membranes via the MAM domain. PMID: 23357641
    7. These results indicate that Npnt plays an important role in the initiation of hepatitis by recruiting CD4(+) T cells or NKT cells into the foci of inflammation. PMID: 23206711
    8. canonical TGF-b signaling through Smad2 regulates Npnt geneexpression in osteoblasts. PMID: 22842459
    9. expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation PMID: 21784074
    10. These results suggest that TNF-alpha inhibits POEM expression through the NF-kappaB signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-alpha. PMID: 21689636
    11. TGF-beta inhibited differentiation of osteoblasts transfected with various truncated Npnt constructs, suggesting that TGF-beta can exert a down-stream effect on Npnt function. PMID: 20452350
    12. it was demonstrated that nephronectin promotes differentiation during osteoblast differentiation and the EGF-like repeats were essential. PMID: 19944102
    13. results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development PMID: 17537792
    14. deregulation of Nephronectin expression plays a role in the development or progression of malignant melanoma. PMID: 18271919
    15. These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence. PMID: 19342381

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix. Note=Trapped on the cell surface or in the extracellular matrix.
  • 蛋白家族：
    Nephronectin family
  • 組織特異性：
    Expressed in kidney (at protein level).
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 亚洲va中文字幕无码一二三区| 中文字幕亚洲无线码在线一区 | 四虎精品成人a在线观看| 久久精品亚洲中文字幕无码网站| 伊人无码精品久久一区二区| 六月丁香亚洲综合在线视频| 国产午夜人做人免费视频网站| 丁香婷婷综合激情五月色 | 99久久国产露脸精品竹菊传媒| 色欧美片视频在线观看| 我的公把我弄高潮了视频| 亚洲香蕉aⅴ视频在线播放 | 午夜福利一区二区三区高清视频| 国产午夜不卡片免费视频| 欧美xxxxx精品| 国产97色在线 | 国产| 免费看成人aa片无码视频| 国产沙发午睡系列999| 四库影院永久四虎精品国产 | 成人做爰www网站视频| 99久久国产露脸精品国产麻豆| 蜜臀久久99精品久久久久久小说| 老熟女高潮喷水了| 麻豆精产国品| 中文无码精品a∨在线观看不卡| 免费va人成视频网站全| 人妻熟女一区二区三区app下载 | 88国产精品视频一区二区三区| 久久久精品人妻一区二区三区 | 亚洲人精品亚洲人成在线 | 国产精品久久久久秋霞鲁丝| 亚洲精品久久av无码一区二区| 夜夜爱夜鲁夜鲁很鲁| 成人做爰69片免费看网站| 欧美日韩不卡视频合集| 4hu四虎永久在线影院| 久爱www成人网免费视频| 99精品久久久久久久婷婷| 亚洲中文字幕无码中文| 人妻聚色窝窝人体www一区| 国产乱国产乱老熟300部视频|