在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse N-myc-interactor (Nmi)

  • 中文名稱:
    小鼠Nmi重組蛋白
  • 貨號:
    CSB-YP015893MO
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Nmi重組蛋白
  • 貨號:
    CSB-EP015893MO-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Nmi重組蛋白
  • 貨號:
    CSB-BP015893MO
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Nmi重組蛋白
  • 貨號:
    CSB-MP015893MO
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    NmiN-myc-interactor; Nmi; N-myc and STAT interactor
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-314
  • 氨基酸序列
    MDADKDNIKQ ACDERSAEMD DMRGEQSMGL VHEIMSENKE LDEEIKKLEA ELQSDAREFQ IKENVPEKKL KLTSVESPKD GCHFSNSSCS FQVSSQILYE LQEGQALITF EKEEVAQNVI SMGNHVVQME GTPVKVSAHP VPLNTGVRFQ VHVDISKMKI NVTGIPDELS EEQTRDKLEL SFCKSRNGGG EVESVDYDRK SRSAVITFVE TGVVDKILKK KTYPLYMNQK CHSVAVSPCI ERCLEKYQVF SAVSKKTVLL TGLEGIPVDE ETGEDLLNIH FQRKNNGGGE VEVVKCSLDQ SFAAYFKEEA RETI
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Acts as a signaling pathway regulator involved in innate immune system response. In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis. Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription. In response to interferon IFN-alpha, associates in a complex with transcriptional regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35. In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries. Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses. Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion. Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines.
  • 基因功能參考文獻(xiàn):
    1. Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways. PMID: 29038465
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus. Secreted.
  • 蛋白家族:
    NMI family
  • 組織特異性:
    Expressed in macrophages.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 久久久噜噜噜久久熟女色| 久久久久88色偷偷| 亚洲乱码日产精品bd在线看 | 麻花豆传媒剧国产免费mv入口| 久久国产精品免费一区二区三区 | 欧美孕妇xxxx做受欧美88| 国产国拍精品av在线观看按摩| 大肉大捧一进一出好爽视频| 成人无码www在线看免费 | 高潮爽死抽搐白浆gif视频| 性av无码天堂vr专区| 亚洲中文字幕无码乱线| 肉岳疯狂69式激情的高潮| 成年无码动漫av片在线观看羞羞| 东京热无码一区二区三区av| 亚洲国产婷婷综合在线精品| 狠狠综合久久av一区二区| 欧美性猛交xxxx乱大交丰满| 337p粉嫩日本欧洲亚福利| 亚洲精品专区成人网站| 中文字幕日韩一区二区不卡| 欧美黑人添添高潮a片www| 黑人好猛厉害爽受不了好大撑| 亚洲乱色伦图片区小说| 久久青青草原精品国产| 欧美刺激性大交| 亚洲欧美色αv在线影视| 国产午夜无码片在线观看影视| 精品国产va久久久久久久冰| 欧美乱色伦图片区| 久久国产美女精品久久| 人人妻人人澡人人爽欧美精品| 欧美放荡的少妇| 抽插丰满内射高潮视频| 国产一区二区三区 韩国女主播| 国产强伦姧在线观看无码| 无码乱人伦一区二区亚洲| 国产精品美女久久久免费| 人妻三级日本香港三级极| 欧美特大特白屁股ass| 无码人妻aⅴ一区二区三区|