在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse N-lysine methyltransferase SMYD2 (Smyd2)

Recombinant Mouse N-lysine methyltransferase SMYD2 (Smyd2)

  • 中文名稱：
    小鼠Smyd2重組蛋白
  • 貨號：
    CSB-YP854521MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Smyd2重組蛋白
  • 貨號：
    CSB-EP854521MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Smyd2重組蛋白
  • 貨號：
    CSB-EP854521MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Smyd2重組蛋白
  • 貨號：
    CSB-BP854521MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Smyd2重組蛋白
  • 貨號：
    CSB-MP854521MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Smyd2
  • Uniprot No.：
  • 別名：
    Smyd2; N-lysine methyltransferase SMYD2; EC 2.1.1.-; Histone methyltransferase SMYD2; EC 2.1.1.354; SET and MYND domain-containing protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-433
  • 氨基酸序列
    MRAEARGGLE RFCSAGKGRG LRALRPFHVG DLLFSCPAYA CVLTVGERGH HCECCFARKE GLSKCGRCKQ AFYCDVECQK EDWPLHKLEC SSMVVLGENW NPSETVRLTA RILAKQKIHP ERTPSEKLLA VREFESHLDK LDNEKKDLIQ SDIAALHQFY SKYLEFPDHS SLVVLFAQVN CNGFTIEDEE LSHLGSAIFP DVALMNHSCC PNVIVTYKGT LAEVRAVQEI HPGDEVFTSY IDLLYPTEDR NDRLRDSYFF TCECRECTTK DKDKAKVEVR KLSSPPQAEA IRDMVRYARN VIEEFRRAKH YKSPSELLEI CELSQEKMSS VFEDSNVYML HMMYQAMGVC LYMQDWEGAL KYGQKIIKPY SKHYPVYSLN VASMWLKLGR LYMGLENKAA GEKALKKAIA IMEVAHGKDH PYISEIKQEI ESH
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
  • 基因功能參考文獻(xiàn)：
    1. Our data indicate that Smyd2 has a critical role downstream of Myc in acute myeloid leukemia PMID: 27655694
    2. two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6/STAT3/SMYD2 and SMYD2/TNF-alpha/NF-kappaB/SMYD2. PMID: 28604386
    3. a pivotal role for SMYD2 in promoting pancreatic cancer. PMID: 26988419
    4. Data show that histone methyltransferase Smyd2 inhibits macrophage interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. production. PMID: 25583990
    5. Smyd2 is a lysine methyltransferase which has, next to its nuclear activity, specific regulatory functions in the cytoplasm of heart and skeletal muscle cells. PMID: 23047121
    6. Sin3A-mediated deacetylation within the coding regions of active genes is directly linked to the histone methyltransferase activity of Smyd2 [Symd2] PMID: 16805913
    7. results show that Smyd2 negatively regulates p53-responsive genes in a p53-dependent manner PMID: 17108971

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 組織特異性：
    Highly expressed in heart, skeletal muscle and brain tissue. During cardiac development, it is differentially expressed with highest expression in the neonatal heart while very low expression is detected at E12.5 and adult. Specifically expressed in cardi
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 日韩内射美女片在线观看网站 | 国产精品嫩草影院av| 国产成人精品无码免费看夜聊软件 | 成全世界免费高清观看| 无码精品人妻一区二区三区人妻斩| 亚洲综合久久无码色噜噜赖水| 中文字幕日韩人妻不卡一区 | 久久婷婷成人综合色| 人妻少妇中文字幕乱码| 999国内精品永久免费视频| 亚洲国产综合无码一区| 久久久亚洲欧洲日产av| 久久中文字幕无码中文字幕有码| 麻豆国产成人av在线播放欲色| 精品动漫一区二区无遮挡| 中文字幕在线播放| 国产午夜无码视频在线观看| 在线看片无码永久免费视频| 国产成久久免费精品av片| 亚洲老熟女av一区二区在线播放 | 亚洲精品久久久久久一区二区| 国内揄拍国产精品人妻门事件 | 久久亚洲国产成人影院| 精品亚洲国产成人av在线时间短的 | 国产天堂亚洲国产碰碰| 一本色道久久hezyo无码| 国产一区二区精品久久| 99视频精品全部免费免费观看| 无码专区6080yy国产电影| 国产裸拍裸体视频在线观看| 日本熟妇人妻中出| 国产98在线 | 日韩| 国产亚洲精品第一综合另类灬| 亚洲sm另类一区二区三区| 精品一区二区av天堂| 国产成人亚洲精品无码h在线| 蜜臀av国产一区二区三区| 韩国无码色视频在线观看| 三级网站视频在在线播放| 欧美激情a∨在线视频播放| 人禽杂交18禁网站免费|