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  4. Recombinant Mouse Muscle, skeletal receptor tyrosine-protein kinase (Musk),Partial

Recombinant Mouse Muscle, skeletal receptor tyrosine-protein kinase (Musk),Partial

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  • 中文名稱：
    小鼠Musk重組蛋白
  • 貨號：
    CSB-EP730715MO
  • 規格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP730715MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Musk.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP730715MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Musk.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Musk
  • Uniprot No.：
  • 別名：
    Musk; Nsk2; Muscle; skeletal receptor tyrosine-protein kinase; EC 2.7.10.1; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Extracellular Domain
  • 來源：
    E.coli
  • 分子量：
    69.3kDa
  • 表達區域：
    22-494aa
  • 氨基酸序列
    EKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKDSQGYCAQYRGEVCDAVLAKDALVFFNTSYRDPEDAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSPGVVPTPMPICREYCLAVKELFCAKEWQAMEGKAHRGLYRSGMHLLPVPECSKLPSMHRDPTACTRLPYLDYKKENITTFPSITSSRPSADIPNLPASTSSFAVSPAYSMT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述：
        肌肉骨架骨骼骨骼受體酪氨酸激酶（MuSK）是一種跨膜蛋白質，主要表達在神經肌肉突觸。MuSK是乙酰膽堿受體信號傳導途徑的關鍵組成部分，對神經肌肉連接的形成和維持至關重要。
        華美生物提供的重組小鼠MuSK蛋白是通過大腸桿菌表達系統制備而成，表達區域為22-494aa。該產品在神經肌肉生物學、肌肉發育和神經肌肉突觸形成等方面有著廣泛的應用。MuSK是乙酰膽堿受體信號傳導途徑中的關鍵分子，參與了神經肌肉連接的形成和維持。深入了解MuSK在神經肌肉突觸形成、神經肌肉疾病等方面的生物學機制。此外，對MuSK的研究還有助于理解肌肉發育和神經肌肉疾病的分子層面機制。
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.
  • 基因功能參考文獻：
    1. Gene expression profiling showed that MuSK was required for the BMP4-induced expression of a subset of genes in myoblasts, including regulator of G protein signaling 4 (Rgs4). PMID: 27601729
    2. These mice showed only marginal activation of MuSK and died by 3 weeks of age apparently due to an abnormally small number and size of neuromuscular junction (NMJs). PMID: 28069867
    3. data reveal that muscle skeletal receptor tyrosine kinase cysteine-rich domain is critical for neuromuscular junction formation and plays an unsuspected role in NMJ maintenance in adulthood. PMID: 25810523
    4. Forced expression of Dok-7 in muscle enhanced MuSK activation in mice lacking agrin or Lrp4 and restored midmuscle NMJ formation in agrin-deficient mice, but not in Lrp4-deficient mice. PMID: 25368159
    5. pathogenic IgG4 antibodies to MuSK bind to a structural epitope in the first Ig-like domain of MuSK, prevent binding between MuSK and Lrp4, and inhibit Agrin-stimulated MuSK phosphorylation. PMID: 24297891
    6. MuSK colocalizes with actin and Arf6 at the cell surface and during endosomal trafficking. PMID: 23621612
    7. Increasing MuSK activity delays denervation and improves motor function in ALS mice. PMID: 22939980
    8. Two classic synaptic signalling systems (neuregulin-1 and neural agrin) converge upon MuSK to regulate postsynaptic differentiation. PMID: 22328506
    9. Biglycan binding to MuSK rescues the unstable acetylcholine receptor clusters that are involved in neuromuscular junction formation and postsynaptic differentiation. PMID: 22396407
    10. Data suggest that adult skeletal muscles harbour different endogenous levels of MuSK and that these levels determine the ability to form ectopic AChR clusters upon overexpression of agrin or MuSK. PMID: 21255125
    11. Depletion of MuSK at the neuromuscular junction leads to disassembly of muscle-specific kinase and muscle weakness of myasthenia gravis in mice. PMID: 20603331
    12. Data show that expression of a chimeric receptor containing the juxtamembrane region of Musk and the kinase domain of TrkA restores presynaptic and postsynaptic differentiation in Musk-deficient mice. PMID: 12403715
    13. Activation of a musk promoter reporter construct in muscle fibers in vivo and in cultured myotubes, using transfection of multiple combinations of expression vectors for potential signaling components PMID: 12756238
    14. analysis of regulation of MuSK expression by a novel signaling pathway PMID: 12885777
    15. Our results suggest that muscle tyrosine phosphatases tightly regulate MuSK activation and signaling and support a novel role of Shp2 in MuSK-dependent AChR clustering. PMID: 15737732
    16. Musk expression was inhibited by CREB interacting with a CRE-like element with MyoD. PMID: 15964791
    17. Our findings demonstrate that MuSK kinase activity is required throughout postnatal development to hold up MuSK and AChR levels at endplates. PMID: 16337809
    18. A low-molecular weight isoform of muscle-specific receptor tyrosine kinase in mouse sperm localized in the flagellar mid-piece region of human sperm. PMID: 16487930
    19. These results demonstrate a novel pathway linking the NO-soluble guanylyl cyclase-cGMP pathway, SR Ca2+ release, PLB, and CaM kinase II to relaxation in gastric fundus smooth muscles. PMID: 16510846
    20. Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK PMID: 16794080
    21. muscle-specific receptor tyrosine kinase activation and binding to dystroglycan are regulated by alternative mRNA splicing of agrin PMID: 17012237
    22. A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor. PMID: 17452444
    23. MuSK controls where motor axons grow and form synapses. PMID: 18084289
    24. the COOH-terminal NES and Src homology 2 target motifs play key roles in Dok-7/MuSK signaling for neuromuscular synaptogenesis. PMID: 18165682
    25. The IGg1/2 domain of MuSK is involved in acetylcholine receptor clustering by binding to the muscle surface. PMID: 18253062
    26. Our study reveals a potentially novel mechanism that regulates agrin/MuSK signaling cascade. PMID: 18272689
    27. adult musk(V789M/-) mice show severe muscle weakness; diaphragm exhibits pronounced changes in endplate architecture, distribution & innervation; missense mutation V789M in MuSK acts as a hypomorphic mutation & leads to insufficiency in MuSK function PMID: 18718936
    28. These experiments indicate that Lrp4 is the long-sought and elusive receptor for Agrin and has a critical role in activating MuSK and stimulating neuromuscular synapse formation. PMID: 18848351

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  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family
  • 組織特異性：
    Expressed preferentially in skeletal muscle.
  • 數據庫鏈接：


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