在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Mothers against decapentaplegic homolog 9 (Smad9)

Recombinant Mouse Mothers against decapentaplegic homolog 9 (Smad9)

  • 中文名稱：
    小鼠Smad9重組蛋白
  • 貨號：
    CSB-YP884919MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Smad9重組蛋白
  • 貨號：
    CSB-EP884919MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Smad9重組蛋白
  • 貨號：
    CSB-EP884919MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Smad9重組蛋白
  • 貨號：
    CSB-BP884919MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Smad9重組蛋白
  • 貨號：
    CSB-MP884919MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Smad9; Madh8; Madh9; Smad8; Mothers against decapentaplegic homolog 9; MAD homolog 9; Mothers against DPP homolog 9; SMAD family member 9; SMAD 9; Smad9; Smad8
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-430
  • 氨基酸序列
    MHPSTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG AMDELERALS CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD LQSHHELKPL ECCEFPFGSK QKEVCINPYH YRRVETPVLP PVLVPRHSEY NPQLSLLAKF RSASLHSEPL MPHNATYPDS FQQSLCPAPP SSPGHVFPQS PCPTSYPHSP GSPSESDSPY QHSDFRPVCY EEPQHWCSVA YYELNNRVGE TFQASSRSVL IDGFTDPSNN RNRFCLGLLS NVNRNSTIEN TRRHIGKGVH LYYVGGEVYA ECVSDSSIFV QSRNCNYQHG FHPATVCKIP SGCSLKVFNN QLFAQLLAQS VHHGFEVVYE LTKMCTIRMS FVKGWGAEYH RQDVTSTPCW IEIHLHGPLQ WLDKVLTQMG SPHNPISSVS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation.
  • 基因功能參考文獻：
    1. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2/RhoA/ROCK/Smad1/5/8 signaling. PMID: 27612439
    2. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. PMID: 26748560
    3. findings suggest that Smad9 is a new type of transcriptional regulator in BMP signaling. PMID: 25534700
    4. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2/Smad1/5/8 and Wnt/beta-catenin pathways. PMID: 25536014
    5. Data indicate that PDGF-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2)-smad proteins smad1/5/8 activation requires lysosome-mediated degradation of PDGF alpha Receptor (PDGFRalpha). PMID: 25470749
    6. our data suggest a pivotal role for canonical BMP signaling demonstrating distinguished nonoverlapping function of pSmad8 with pSmad1 and pSmad5 in hfSCs regulation and hair morphogenesis but a redundant role in adult hair progenitors differentiation. PMID: 24023003
    7. FGF2 inhibited BMP9-induced osteogenic differentiation by blocking BMP9-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2 in mesenchymal stem cells. PMID: 23680673
    8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. PMID: 23804438
    9. BMP4-mediated signaling in adult mouse ovary-derived oogonial stem cells cultured in vitro drives differentiation of these cells into oocytes through Smad1/5/8 activation and transcriptional up-regulation of key meiosis-initiating genes. PMID: 23993924
    10. Endogenous FGF2 is necessary for BMP-2 induced nuclear accumulation and co-localization of Runx-2 and phospho-Smads1/5/8. PMID: 23559326
    11. Smad8/BMP2-engineered mesenchymal stem cells induce accelerated recovery of the biomechanical properties of the Achilles tendon PMID: 22696396
    12. Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney. PMID: 11850197
    13. Smad8 has critical function in the development of the mammalian central nervous system. PMID: 15899870
    14. results suggest that BMP2/BMP4 signalling through SMAD 8 is required for transcriptional activation of the mouse Msx1 gene PMID: 16101586
    15. we demonstrate that BMP-2, -5, and -7 stimulate receptor-activated Smad1, 5, and 8, which in turn causes oligomerization of Smad4 in the nucleus. PMID: 16522160
    16. Initially expressed only in the visceral yolk sac endoderm and shows a highly restricted pattern of expression in the embryo proper at later stages. PMID: 16765933
    17. Data show that Smad8 expression is ubiquitous during testis development but becomes cell-specific in the adult. PMID: 18069690
    18. Smad8 loss of function resulted in changes in pulmonary arteries including medial thickening and smooth muscle hyperplasia observed in patients with pulmonary artery hypertension. PMID: 19419974

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
  • 蛋白家族：
    Dwarfin/SMAD family
  • 數據庫鏈接：


主站蜘蛛池模板： 国产综合有码无码中文字幕| 久久久久久亚洲综合影院| 亚洲v国产v天堂a无码二区| 深夜国产成人福利在线观看| 亚洲精品国产一区二区的区别 | 中文精品久久久久人妻| 午夜福利影院私人爽爽| 狠狠噜狠狠狠狠丁香五月| 久久精品国产亚洲αv忘忧草| 国产乱色国产精品播放视频| 国产一区二区三区乱码在线观看| 精品国产不卡一区二区三区| 一区二区三区四区在线 | 中国| 少妇被又大又粗猛烈进出视频| 免费精品国产自在| 无码日韩人妻精品久久蜜桃| 自愉自愉产区二十四区| 欧美成va视频网站| 不卡无码人妻一区二区三区| 伊人久久大香线蕉av网| 免费观看亚洲人成网站| 色偷偷av男人的天堂| 天堂а√中文最新版在线| 国产欧美日韩精品专区| 亚洲国产av精品一区二区蜜芽| 强睡邻居人妻中文字幕| 国产第一页屁屁影院| 国产在线高清亚洲精品二区| 青青草99久久精品国产综合| 成人免费ā片在线观看| av无码精品一区二区三区宅噜噜| 亚洲不乱码卡一卡二卡4卡5卡| 亚洲欧洲自拍拍偷精品网| 2021国产成人精品久久| 免费无码精品黄av电影| 国产午夜福利精品一区二区三区 | 国产日产欧产精品精品免费| 欧美国产亚洲日韩在线二区| 日本中文字幕在线| 欧美丰满大乳大屁股流白浆| 天天综合色天天综合色h|