在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), partial

Recombinant Mouse Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), partial

  • 中文名稱：
    小鼠Map4k4重組蛋白
  • 貨號(hào)：
    CSB-YP013439MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Map4k4重組蛋白
  • 貨號(hào)：
    CSB-EP013439MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Map4k4重組蛋白
  • 貨號(hào)：
    CSB-EP013439MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Map4k4重組蛋白
  • 貨號(hào)：
    CSB-BP013439MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Map4k4重組蛋白
  • 貨號(hào)：
    CSB-MP013439MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Map4k4; NikMitogen-activated protein kinase kinase kinase kinase 4; EC 2.7.11.1; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
  • 基因功能參考文獻(xiàn)：
    1. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells. PMID: 28771231
    2. Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity. PMID: 28611026
    3. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate. PMID: 27044870
    4. These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from beta cells in mice. PMID: 27226575
    5. These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis. PMID: 26688060
    6. Mice with Map4k4 deleted in Myf5-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin resistance. PMID: 25918248
    7. pkj ;oi oi pi oy oliuh PMID: 25601402
    8. microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2 PMID: 25490267
    9. MAP4K4 is essential for CD4+ T cell proliferation and activation in vitro through suppressing PKC-theta activation. PMID: 24681727
    10. Expression of a Map4k4 kinase-inactive mutant enhances myotube formation, suggesting that the kinase activity of Map4k4 is essential for its inhibition of muscle differentiation. PMID: 23207904
    11. MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells. PMID: 22733810
    12. These data together with previous reports on extramedullary hemopoiesis in RelB-deficient mice suggest that NIK-RelB signaling may be involved in the suppression of extramedullary hemopoiesis in adult mice. PMID: 22005462
    13. inhibitory effect of the NIK aly mutation on the process of osteoclast differentiation is, at least in part, closely linked to the alternative NF-kappaB signaling pathway. PMID: 19874202
    14. Map4k4 negatively regulates PPARgamma post-transcriptionally, by attenuating mTOR signaling and a 4E-BP1-dependent mechanism PMID: 20038583
    15. These results reveal a MAP4K4/NIK-dependent signaling pathway that potently inhibits PPARgamma-responsive gene expression PMID: 16461467

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Appears to be ubiquitous, expressed in all tissue types examined. Highest levels observed in heart and brain.
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 黄网在线观看免费网站| 日本日本乱码伦专区| 最新国产成人无码久久| 国产日产欧产精品网站| 久久亚洲精品成人av| 理论片87福利理论电影| 亚洲区欧美区综合区自拍区| 综合精品欧美日韩国产在线| 米奇7777狠狠狠狠视频影院| 欧美成人片在线观看| 国产成人精品综合久久久久| 久久精品人人爽人人爽| 无码专区6080yy国产电影| 日本少妇毛茸茸高潮| 337p西西人体大胆瓣开下部| 激情偷乱人伦小说视频| 午夜131美女爱做视频| 少妇大叫太大太爽受不了| 欧美乱妇高清无乱码在线观看| 一性一交一口添一摸视频| 香蕉蕉亚亚洲aav综合| 久久久久人妻一区视色| 人妻丰满熟妇av无码区乱| 欧美96在线 | 欧| 国产精自产拍在线看中文| 色偷偷女人的天堂亚洲网| 亚洲日韩aⅴ在线视频| 在线天堂新版最新版在线8| 国产aⅴ爽av久久久久久| 国产精品调教视频一区| 国色天香中文字幕在线视频| 在厨房拨开内裤进入在线视频| 亚洲aⅴ永久无码一区二区三区| 国产做a爰片久久毛片a片美国| 丝袜 中出 制服 人妻 美腿 | 漂亮人妻洗澡被公强 日日躁| 无码熟妇人妻av| 好男人社区www在线官网| 99视频国产精品免费观看| 性高朝久久久久久久| 国内精品久久久久伊人av|