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  4. Recombinant Mouse Microtubule-associated tumor suppressor 1 homolog (Mtus1), partial

Recombinant Mouse Microtubule-associated tumor suppressor 1 homolog (Mtus1), partial

  • 中文名稱：
    小鼠Mtus1重組蛋白
  • 貨號：
    CSB-YP686291MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mtus1重組蛋白
  • 貨號：
    CSB-EP686291MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mtus1重組蛋白
  • 貨號：
    CSB-EP686291MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mtus1重組蛋白
  • 貨號：
    CSB-BP686291MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mtus1重組蛋白
  • 貨號：
    CSB-MP686291MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mtus1
  • Uniprot No.：
  • 別名：
    Mtus1; Atbp; Atip; Cctsg1; Kiaa1288; Mtsg1; Microtubule-associated tumor suppressor 1 homolog; AT2 receptor-binding protein; Angiotensin-II type 2 receptor-interacting protein; Coiled-coiled tumor suppressor gene 1 protein; Mitochondrial tumor suppressor 1 homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation.
  • 基因功能參考文獻：
    1. important role in AT2 receptor-mediated PPARgamma activation PMID: 26471325
    2. ATIPs seem to be mainly involved in the developmental regulation of the cardiovascular system and may act in different AT2-dependent and -independent manners. PMID: 24288149
    3. ATIP1 could exert anti-inflammatory effects in adipose tissue via macrophage polarization associated with improvement of insulin resistance. PMID: 23565185
    4. analysis of a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration in breast cancer PMID: 23396587
    5. Reports the first generation of a MTUS1 KO mouse, developing spontaneous heart hypertrophy and increased cell proliferation, confirming once more the anti-proliferative effect of MTUS1, and a SLE-like lymphoproliferative disease. PMID: 22200760
    6. ATIP3 is a novel microtubule-associated protein related to MTUS1, with a role in invasiveness and progression of breast neoplasms PMID: 19794912
    7. Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade. PMID: 15123706
    8. ATIP1 plays an important role in cuff-induced vascular remodeling in mice PMID: 19221207

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  • 亞細胞定位：
    Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II.
  • 蛋白家族：
    MTUS1 family
  • 組織特異性：
    Ubiquitously expressed, with highest levels in uterus and adrenal gland.
  • 數據庫鏈接：

    KEGG: mmu:102103

    UniGene: Mm.149438



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