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  4. Recombinant Mouse Metal transporter CNNM2 (Cnnm2), partial

Recombinant Mouse Metal transporter CNNM2 (Cnnm2), partial

  • 中文名稱：
    Recombinant Mouse Metal transporter CNNM2(Cnnm2) ,partial
  • 貨號：
    CSB-YP668848MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Metal transporter CNNM2(Cnnm2) ,partial
  • 貨號：
    CSB-EP668848MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Metal transporter CNNM2(Cnnm2) ,partial
  • 貨號：
    CSB-EP668848MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Metal transporter CNNM2(Cnnm2) ,partial
  • 貨號：
    CSB-BP668848MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Metal transporter CNNM2(Cnnm2) ,partial
  • 貨號：
    CSB-MP668848MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cnnm2
  • Uniprot No.：
  • 別名：
    Cnnm2; Acdp2Metal transporter CNNM2; Ancient conserved domain-containing protein 2; mACDP2; Cyclin-M2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).
  • 基因功能參考文獻：
    1. we generated kidney-specific Cnnm2- deficient mice and clearly demonstrated that the CNNM2 function in the kidney is important in maintaining not only magnesium homeostasis but also blood pressure. PMID: 28033128
    2. data shed new light on the structural basis underlying the interaction between PRL phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1, upon binding to CNNM2, might increase the intracellular concentration of Mg(2+) thereby contributing to tumor progression and metastasis. PMID: 27899452
    3. Thus, sperm motility and Ca(2+) response were more severely affected in sperm from Cnnm2(+/Delta); Cnnm4(Delta/Delta) mice than in those from Cnnm4(Delta/Delta) mice, implicating CNNM2 in regulating these processes. PMID: 27150626
    4. analysis of structure of CNNM2 and its post-translational modifications PMID: 22399287
    5. ACDP2 may provide a regulated transporter for Mg2+ and other divalent cations in epithelial ce PMID: 15899945

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ACDP family
  • 組織特異性：
    Widely expressed, with highest levels in kidney, lung, spleen and testis. In the kidney, predominantly expressed in the distal convoluted tubule and, at lower levels, in the connecting tubule (at protein level).
  • 數據庫鏈接：


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