在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Metabotropic glutamate receptor 7 (Grm7), partial

  • 中文名稱:
    小鼠Grm7重組蛋白
  • 貨號:
    CSB-YP715014MO
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Grm7重組蛋白
  • 貨號:
    CSB-EP715014MO
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Grm7重組蛋白
  • 貨號:
    CSB-EP715014MO-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Grm7重組蛋白
  • 貨號:
    CSB-BP715014MO
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Grm7重組蛋白
  • 貨號:
    CSB-MP715014MO
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Grm7; Gprc1g; Mglur7Metabotropic glutamate receptor 7; mGluR7
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
  • 基因功能參考文獻:
    1. mGlu7 may be a potential therapeutic target for multiple aspects of the Rett phenotype. PMID: 28814546
    2. The mGlu7 receptor was found to be involved in a wide range of behavioral and physiological alterations in response to chronic psychosocial stress exposure. PMID: 27188844
    3. This study provides evidence for mGlu7 receptor-mediated tonic modulation of a physiological function in vivo preventing synchronous and potentially pathological oscillations. PMID: 27199672
    4. Analysis of mGluR7 KO mice, c-Fos expression, and cerebral MMPIP microinjection indicate that inhibition of mGluR7 impairs intermale aggression owing to information processing dysfunction within the bed nucleus of the stria terminalis PMID: 26149357
    5. muscle does not appear to require high levels of SMN above what is produced by two copies of SMN2 PMID: 26276812
    6. SAM68 is a physiological regulator of SMN2 splicing in a spinal muscular atrophy mouse model. PMID: 26438828
    7. Hyperoxia treatment increased the inclusion of SMN2 exon 7 in skeletal muscles and resulted in improved motor function. PMID: 22763238
    8. Elfn1 recruits mGluR7 to synaptic sites.A trans interaction of Elfn1 and mGluR7 controls targeted interneuron synapse development. PMID: 25047565
    9. GRM7 regulates the phosphorylation of CREB protein and the expression of Yes-associated protein (YAP) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development. PMID: 25921811
    10. Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design PMID: 24596089
    11. The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression PMID: 23664812
    12. These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders. PMID: 23603202
    13. Glutamate release mediated by GluR7 at nerve terminals is influenced by divalent calcium channel type Ca2+ ionophore. PMID: 23174341
    14. mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function PMID: 22287544
    15. The genomic integration site of the mGluR7 transgene is in intron 4 in spinal muscular atrophy transgenic mice, especially those that have extended survival. PMID: 21396450
    16. Phorbol esters and prolonged activation of mGlu7 receptors both potentiate glutamate release via a common intracellular signalling pathway that occurs in nerve terminals containing N-type divalent calcium channels. PMID: 21143597
    17. This study suggested that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA. PMID: 20353761
    18. mGlu7 receptors may not only regulate the central components of chronic stress, but may also have a role in the regulation of fluid & electrolyte transport which is significantly disrupted in diseases such as IBS, by enhancing colonic secretory activity PMID: 20423346
    19. The mGluR7 may play a pivotal role in mechanisms that regulate behavioural responses to aversive states. Therefore, drugs acting at mGluR7 may provide novel treatments for psychiatric disorders such as depression and anxiety. PMID: 12814372
    20. genetic ablation of mGluR7 in mice interferes at multiple sites in the neuronal circuitry and molecular pathways implicated in affective disorders. PMID: 16237391
    21. mGluR4 and mGluR7 were located close to bipolar cell ribbons PMID: 17311335
    22. Metabotropic glutamate receptor 7 (GluR7) is uniquely expressed in dendrites of the ON cone bipolar cell pathway and reveals a unique connection to rod cells. PMID: 17553999
    23. gene mapping and gene mRNA expression data in segregating and congenic mice identify glutamate receptor metabotropic 7 (Grm7) as a cis-regulated gene and suggest a role in alcohol consumption PMID: 17936574
    24. The observed delays in the acquisition of complicated stimulus associations across conditioning procedures may suggest a critical role for mGluR7 in neurocognitive functions and psychopathology PMID: 18289889
    25. group III mGluRs regulate spontaneous glutamate release of terminals projecting to dopamine cells in the ventral tegmental area of mice and this effect is most likely mediated by mGluR7 PMID: 18534761
    26. PICK1 binding to the C-terminal region of mGluR7a is crucial for agonist-triggered presynaptic signaling in vivo. PMID: 18716219
    27. GRM7 is expressed in the hair cells and in spiral ganglion cells of the inner ear of human and mouse. PMID: 19047183

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 3 family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 嘿咻嘿咻男女免费专区| 秋霞午夜久久午夜精品| 日韩av爽爽爽久久久久久| 潮喷无码正在播放| av片在线观看| 无码h片在线观看网站| 日韩欧无码一二三区免费不卡| 国产sp调教打屁股视频网站| 午夜福利92国语| 亚洲国产欧美国产综合一区| 欧美成人va免费大片视频| 亚洲手机在线人成网站| 色综合久久久无码中文字幕波多 | 国产三级在线观看播放视频| 亚洲色大成网站www永久男同| 少妇性l交大片7724com| 色欲天天天综合网| 超清中文乱码一区| 国产成人艳妇aa视频在线| 亚洲熟女精品中文字幕| 内射视频←www夜| 久久99精品九九九久久婷婷| 国产午夜无码视频在线观看| 黑人粗大猛烈进出高潮视频| 无码人妻精品一区二区三区下载| 一区二区在线 | 欧洲| 国产成人亚洲精品狼色在线| 亚洲中文字幕无码中文| 亚洲色www成人永久网址| 99精品免费久久久久久久久日本| 换脸国产av一区二区三区| 扒开双腿猛进入喷水高潮视频| 亚洲精品久久| 中文无码成人免费视频在线观看| 国内精品乱码卡一卡2卡麻豆| 99久久精品国产波多野结衣 | 亚洲a∨无码一区二区三区| 久久精品a亚洲国产v高清不卡| 挺进邻居丰满少妇的身体| 久久精品国产亚洲αv忘忧草| 欧美一区二区三区啪啪|