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  4. Recombinant Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Magi1), partial

Recombinant Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Magi1), partial

  • 中文名稱：
    小鼠Magi1重組蛋白
  • 貨號：
    CSB-YP754335MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Magi1重組蛋白
  • 貨號：
    CSB-EP754335MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Magi1重組蛋白
  • 貨號：
    CSB-EP754335MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Magi1重組蛋白
  • 貨號：
    CSB-BP754335MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Magi1重組蛋白
  • 貨號：
    CSB-MP754335MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Magi1; Baiap1; Bap1; Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 1; BAI1-associated protein 1; BAP-1; Membrane-associated guanylate kinase inverted 1; MAGI-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
  • 基因功能參考文獻：
    1. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure PMID: 27707879
    2. Cx32 expression is in part related to induction of tight junctions through modulation of Magi1 expression in an immortalized hepatic cell line. PMID: 15558322
    3. ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct. PMID: 23523645
    4. Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function. PMID: 20562105
    5. Depletion of MAGI-1 from photorecptors by RNA interference blocks synaptic localization of Sidekick-2 in photoreceptors without affecting localization of postsynaptic density (PSD)-95. PMID: 20219992
    6. MAGI-1 together with JAM4 provides an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells PMID: 12773569
    7. We found MAGI-1 to be associated with cell-cell contacts in human umbilical vein endothelial cells (HUVECs) and in mouse endothelium, where it colocalizes with ESAM. PMID: 15383320
    8. MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis. PMID: 17191119

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  • 亞細胞定位：
    [Isoform 2]: Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, tight junction.; [Isoform 3]: Cytoplasm. Cell membrane; Peripheral membrane protein.; [Isoform 1]: Nucleus.
  • 組織特異性：
    Widely expressed, including kidney glomeruli.
  • 數據庫鏈接：


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