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  4. Recombinant Mouse Macrophage receptor MARCO (Marco), partial

Recombinant Mouse Macrophage receptor MARCO (Marco), partial

  • 中文名稱：
    小鼠Marco重組蛋白
  • 貨號：
    CSB-YP726671MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Marco重組蛋白
  • 貨號：
    CSB-EP726671MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Marco重組蛋白
  • 貨號：
    CSB-EP726671MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Marco重組蛋白
  • 貨號：
    CSB-BP726671MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Marco重組蛋白
  • 貨號：
    CSB-MP726671MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    MarcoMacrophage receptor MARCO; Macrophage receptor with collagenous structure
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2.
  • 基因功能參考文獻：
    1. the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO. PMID: 29769337
    2. presence of MARCO allows rapid Adenovirus (AD) gene expression and strong virus-stimulated innate responses; blockage or lack of MARCO results in strong impairment of these processes;. MARCO is involved in innate Ad recognition and the elevated Ad sensitivity of MARCO-expressing macrophages is due to the expression of this receptor on the cell surface PMID: 28765216
    3. Common damage-associated molecular patterns (DAMPs) were internalized through the class A scavenger receptors MSR1 and MARCO in vitro. In ischemic murine brain, DAMP internalization was largely mediated by MSR1. Combined deficiency for Msr1 and Marco in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke. PMID: 28394332
    4. Increasing MARCO expression by targeting Nrf2 signaling or the Akt-TFEB-MARCO pathway are promising strategies to improve bacterial clearance and survival in postinfluenza bacterial pneumonia. PMID: 28408365
    5. free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria. PMID: 28385809
    6. this study shows that Marco functions as co-receptor along with TLRs for HMGB1 in M1-type inflammatory macrophages PMID: 28338748
    7. MARCO Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway PMID: 26545255
    8. our data demonstrate that MARCO differentially affects TLR-induced DC activation and suggest targeting of MARCO could lead to different outcomes that depend on the inflammatory context encountered by dendritic cells. PMID: 25089703
    9. Vaccinia virus bound directly to MARCO, and overexpression of MARCO increased susceptibility to vaccinia infection. PMID: 25089661
    10. MARCO-/- dendritic cells demonstrated enhanced migratory capacity in response to CCL-21 in vitro. PMID: 23840879
    11. herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease. PMID: 23739639
    12. results indicate that accumulation of SQSTM1 leads to increased activation of NFE2L2 and the subsequent increase in MARCO and MSR1 PMID: 24035364
    13. this study, we confirm that tolerized mouse bone marrow-derived macrophages selectively increase expression of MARCO and increase phagocytosis PMID: 23667110
    14. MARCO is an important component of anti-Streptococcus pneumoniae responses in murine nasopharyngeal macrophages during bacterial colonization. PMID: 23197261
    15. Fetuin-A-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A. PMID: 22753077
    16. These results indicate that MARCO suppresses a protective early inflammatory response to influenza, which modulates viral clearance and delays recovery. PMID: 21562316
    17. SR-A/MARCO-mediated rapid ligand internalization prevented sensing by surface TLRs while increasing ligand availability in intracellular compartments, thus allowing sensing and robust responses by intracellular sensors. PMID: 21098741
    18. MARCO is an important phagocytic receptor used by human and mouse macrophages to clear C. sordellii from the infected uterus PMID: 20810988
    19. The MARCO receptor may account for the variable species susceptibility towards dalcetrapib-mediated chylomicron uptake by macrophages PMID: 20074633
    20. TLR4 engagement by LPS leads to increased expression of NARCO, which feedback-regulates LPS responses, changling cytokine & anti-LPS Ab production. MARCO contributes to the efficient capturing & clearance of invading microbial pathogens. PMID: 20162551
    21. An arginine-rich segment in domain V of MARCO and particularly its RXR motifs play a critical role in high affinity bacterial binding. PMID: 11820786
    22. MARCO receptor is important for actin cytoskeleton rearrangements and the down-regulation of antigen uptake function during DC and microglial cell maturation PMID: 12842997
    23. MARCO has an important role in mounting an efficient and appropriately regulated innate immune response against inhaled particles and airborne pathogens PMID: 15263032
    24. Th1 adjuvants increased, whereas Th2-polarizing factors decreased expression of MARCO on J774 macrophage-like cells; MARCO-deficient mice exhibited 2.7 times lower IL-12 production in responses to stimulation PMID: 16339540
    25. both MARCO and SR-A could be involved in the positioning and differentiation of macrophages, possibly through interaction with endogenous ligands PMID: 16339556
    26. MARCO is the primary alveolar macrophages receptor responsible for silica uptake and cell death signaling PMID: 16984918
    27. Marco decreases inflammation in the lungs exposed to ozone. PMID: 17332894
    28. Together, these data indicate that SRA controls inflammatory cytokines produced by alveolar macrophages in the context of P. carinii infection. PMID: 17548480
    29. We have confirmed a role for Marco in the clearance of apoptotic cells and a generalized defect in both endocytosis and phagocytosis PMID: 19201851
    30. MARCO expression by CBA/J macrophages is increased in response to both in vitro and in vivo L. major infections, but not to L. amazonensis infection. MARCO has a role in macrophage infection by L. major in vitro as well as in vivo. PMID: 19292770
    31. results show MARCO-expressing macrophages secrete pro-inflammatory cytokines in response to Mycobacterium tuberculosis trehalose 6,6'-dimycolate(TDM) by cooperation between MARCO & TLR2/CD14; MARCO identified as novel component required for TLR signaling PMID: 19521507

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  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes (at protein level).
  • 數據庫鏈接：


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