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  4. Recombinant Mouse Lysosomal-associated transmembrane protein 5 (Laptm5), partial

Recombinant Mouse Lysosomal-associated transmembrane protein 5 (Laptm5), partial

  • 中文名稱：
    小鼠Laptm5重組蛋白
  • 貨號：
    CSB-YP720241MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Laptm5重組蛋白
  • 貨號：
    CSB-EP720241MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Laptm5重組蛋白
  • 貨號：
    CSB-EP720241MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Laptm5重組蛋白
  • 貨號：
    CSB-BP720241MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Laptm5重組蛋白
  • 貨號：
    CSB-MP720241MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Laptm5
  • Uniprot No.：
  • 別名：
    Laptm5; Lysosomal-associated transmembrane protein 5; Lysosomal-associated multitransmembrane protein 5; Retinoic acid-inducible E3 protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May have a special functional role during embryogenesis and in adult hematopoietic cells.
  • 基因功能參考文獻：
    1. these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling. PMID: 24638062
    2. the pre-BCR induces the downmodulation of its own expression through induction of LAPTM5, which promotes the lysosomal transport and degradation of the intracellular pre-BCR pool and limits the supply of pre-BCR to the cell surface PMID: 22949502
    3. LAPTM5 acts as a positive modulator of inflammatory signaling pathways and hence cytokine secretion in macrophages PMID: 22733818
    4. LAPTM5 physically interacts with the B cell receptor complex and promotes its degradation in the lysosomal compartment in mouse B cells. PMID: 20519653
    5. the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain and promoting its degradation PMID: 18619870

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  • 亞細胞定位：
    Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    LAPTM4/LAPTM5 transporter family
  • 組織特異性：
    Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues.
  • 數據庫鏈接：


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