在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Lysine-specific demethylase PHF2 (Phf2), partial

Recombinant Mouse Lysine-specific demethylase PHF2 (Phf2), partial

  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-YP895738MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-EP895738MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-EP895738MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-BP895738MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-MP895738MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Phf2
  • Uniprot No.：
  • 別名：
    Phf2; Kiaa0662; Lysine-specific demethylase PHF2; EC 1.14.11.-; GRC5; PHD finger protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
  • 基因功能參考文獻：
    1. The paper's findings establish a downstream epigenetic checkpoint, whereby Phf2, through facilitating H3K9me2 demethylation at specific gene promoters, protects liver from the pathogenesis progression of Non-alcoholic Fatty Liver Disease. PMID: 29844386
    2. these results demonstrate that PHF2 histone demethylase controls adipogenic gene expression during differentiation. PMID: 25266703
    3. PHF2 enhances osteoblast differentiation by demethylating Runx2, while suppressor of variegation 3-9 homolog 1 (SUV39H1) inhibits bone formation by methylating it. PMID: 25257467
    4. Arid5b recruits Phf2 to the promoter region of Sox9 target genes and stimulates H3K9me2 demethylation of these genes. PMID: 24276541
    5. Data from PHF2 knockout mice suggest that PHF2 plays roles in both adipogenesis and neonatal growth/weight gain; PHF2 interacts with promoter region of CEBPA (CCAAT-enhancer binding protein alpha) gene and demethylates histones in chromatin. PMID: 23274892
    6. histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation PMID: 20129925

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    JHDM1 histone demethylase family, JHDM1D subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 国产丰满人妻一区二区 | 欧美va亚洲va在线观看日本| 人妻少妇精品视频无码综合| 亚洲国产成人av网站| 无码人妻丝袜在线视频红杏| 国内精品久久人妻互换| 人禽伦免费交视频播放| 中文字幕日产无码| 亚洲精品亚洲人成在线观看| 在线观看潮喷失禁大喷水无码| 伊人久久精品亚洲午夜| 色噜噜狠狠狠狠色综合久一| 国产在线aaa片一区二区99| 精品久久一区二区乱码| 亚洲男人成人性天堂网站| 国产成人综合在线视频| 国产特级毛片aaaaaa毛片| 中文字幕一区二区人妻电影| 精品国产乱码久久久久久乱码| 国产无遮挡又爽又黄的视频| 国产精品久久久久久福利 | a国产在线v的不卡视频| 无码av中文一区二区三区| 亚洲人成图片小说网站| 无遮挡裸体免费视频尤物| 台湾佬中文娱乐22vvvv| 国产成人无码av片在线观看不卡| 少妇爱做高清免费视频| 制服丝袜另类专区制服| 国产乱人对白| 亚洲欧美日韩国产综合在线一区| 欧产日产国产精品| 久久精品视频在线看| 色爽黄1000部免费软件下载| 香港三级日本三级a视频| 青青草国产久久精品| 亚洲欧美国产免费综合视频| 亚洲中文字幕无码中字| 国产成人综合亚洲色就色| 久久亚洲精品人成综合网| 午夜大片免费男女爽爽影院|