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  4. Recombinant Mouse Lysine-specific demethylase 6B (Kdm6b), partial

Recombinant Mouse Lysine-specific demethylase 6B (Kdm6b), partial

  • 中文名稱：
    小鼠Kdm6b重組蛋白
  • 貨號：
    CSB-YP686744MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kdm6b重組蛋白
  • 貨號：
    CSB-EP686744MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kdm6b重組蛋白
  • 貨號：
    CSB-EP686744MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kdm6b重組蛋白
  • 貨號：
    CSB-BP686744MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kdm6b重組蛋白
  • 貨號：
    CSB-MP686744MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kdm6b
  • Uniprot No.：
  • 別名：
    Kdm6b; Jmjd3; Kiaa0346Lysine-specific demethylase 6B; EC 1.14.11.-; JmjC domain-containing protein 3; Jumonji domain-containing protein 3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex.
  • 基因功能參考文獻：
    1. Mechanistic exploration identified a physical and functional association of JMJD3 with C/EBPbeta that presides the regulatory network of JMJD3. PMID: 30135572
    2. Our data show that chemical inhibition of the H3K27me3 demethylases Jmjd3/Utx blunts Neurogenin3-dependent gene activation in vitro. Conversely, inhibition of the H3K27me3 methyltransferase Ezh2 enhances both the transactivation ability of Neurogenin3 in cultured cells and the formation of insulin-producing cells during directed differentiation from pluripotent cells PMID: 29530603
    3. Study indicates sequential chromatin events and identifies a crucial role for Jmjd3 in regulating the efficiency of the transition from Ngn3-low to Ngn3-high cells. PMID: 29559448
    4. When JMJD3 levels were decreased by RNA interference, the embryo development rate and quality were improved, but the knockdown of UTX produced the opposite results. PMID: 27384759
    5. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
    6. Results identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells. PMID: 28322580
    7. These results suggest that the demethylase activity of Jmjd3, but not that of Utx, affects mouse axial patterning in concert with alterations in Hox gene expression. PMID: 28188179
    8. Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop. PMID: 28323958
    9. Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples. PMID: 28314754
    10. Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming. PMID: 28328977
    11. Study provides evidence that miR-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b. PMID: 28587848
    12. the redox regulation of Jmjd3 is a unique regulatory mechanism for Cu,Zn-superoxide dismutase-mediated profibrotic macrophage polarization. PMID: 26699812
    13. our study has attributed novel roles for JMJD3 and its regulators during mycobacterial infection that assist foamy macrophage generation and fine-tune associated host immunity PMID: 27532872
    14. ISL1 and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation. PMID: 27105846
    15. Histone H3 lysine-27 demethylase (H3K27me3 demethylase) activity would act as a negative regulator of dendritic cells (DCs). PMID: 27528513
    16. nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells PMID: 27017927
    17. differentiating embryonic stem cells (ESCs) depend on KDM6 and the H3K27me3 demethylase activity is crucially involved in DNA damage response and survival of differentiating ESCs. PMID: 26759175
    18. JMJD3 up-regulation and NF-kappaB activation occur in the region of the wound edge during keratinocyte wound healing PMID: 26802933
    19. these studies established a critical role of Jmjd3-mediated H3K27 demethylation in Th17 cell differentiation and suggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. PMID: 25840993
    20. These results strongly demonstrated that JMJD3 is required for osteoblast differentiation and bone formation in mice. PMID: 26302868
    21. APN can help to reduce periodontitis-related bone loss, modulate JMJD3 and IRF4 expression, and macrophage infiltration. PMID: 26399931
    22. JMJD3 is an epigenetic regulator in development and disease. (Review) PMID: 26193001
    23. Jmjd3 is required for T-cell development. PMID: 26328764
    24. Jmjd3-catalyzed erasure of H3K27me3 is required for brown fat gene expression and browning of white fat. PMID: 26625958
    25. Utx and Jmjd3 mutant mouse embryonic fibroblasts (MEFs) demonstrate dramatic loss of H3K27me3 from promoters of several Hox genes and transcription factors. PMID: 25101834
    26. Jmjd3 is an epigenetic factor in T-cell differentiation via changes in histone methylation and target gene expression. PMID: 25531312
    27. JMJD3 is a key epigenetic regulator in the process of cartilage maturation during endochondral bone formation. PMID: 25587042
    28. Inhibition of histone demethylases UTX and JMJD3 inhibits HSV-1 reactivation from sensory neurons. PMID: 25552720
    29. JMJD3 is required for postnatal and adult subventricular zone neurogenesis. PMID: 25176653
    30. These data reveal a novel function for Kdm6b in activity-regulated neuronal survival, and that activity- and Kdm6b-dependent regulation of inflammatory gene pathways may serve as an adaptive pro-survival response to increased neuronal activity. PMID: 24983519
    31. Depletion of Jmjd3 expression also attenuated the release of proinflammatory cytokine genes in a peritonitis model and ameliorated neutrophilia in Serum amyloid A-stimulated mice. PMID: 24703936
    32. Our study provides molecular insights into the mechanisms by which Jmjd3 regulates target gene expression in the embryonic stages of lung development. PMID: 25079229
    33. Studies indicate that Jmjd3 is able to enhance the polarization of M2 microglia by modifying histone H3K27me3, and it has a pivotal role in the switch of microglia phenotypes that may contribute to the immune pathogenesis of PD. PMID: 24212761
    34. JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation; by contrast, UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL PMID: 25132549
    35. HIF-1a and its dimerization partner HIF-1b/Arnt occupy the first intron region of the mouse JMJD3 gene. PMID: 24552709
    36. Stat1 and Stat3 cooperate with Jmjd3 to induce the expression of pro-inflammatory genes. PMID: 24097101
    37. JMJD3 controls the spermatogonial compartment through the regulation of fragmentation of spermatogonial cysts and this mechanism may be involved in maintenance of diverse stem cell niches. PMID: 23967333
    38. Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. PMID: 24289921
    39. Jmjd3 is required for embryonic stem cells differentiation to the endothelial and cardiac lineage. PMID: 23856522
    40. Ectopic gain of EED along with depletion of KDM6B in preimplantation mouse embryos abrogates CDX2 and GATA3 gene expression in the nascent trophoectoderm lineage. PMID: 23671187
    41. Jmjd3 sequentially associates with two T-box factors, Tbx3 and Eomes to drive stem cell differentiation towards the definitive endoderm lineage. PMID: 23584530
    42. JMJD3 demethylates H3K27me3 along the gene bodies, paving the way for the RNAPII progression. PMID: 23243002
    43. The enzymatic activity of JMJD3 is required for the maintenance of the pre-Botzinger complex and controls critical regulators of pre-Botzinger complex activity. PMID: 23103168
    44. These data demonstrate a novel role of H3 Lys27 histone methylation in fibrosis in systemic sclerosis. PMID: 22915621
    45. Overexpression of KDM6B induced the expression of mesenchymal genes and promoted epithelial-mesenchymal transition. PMID: 23152497
    46. ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. PMID: 22955275
    47. UTX controls mesoderm differentiation and Brachyury expression independent of H3K27 demethylase activity; UTX and UTY are functionally redundant in ES cell differentiation and early embryonic development PMID: 22949634
    48. neurogenesis is promoted by an interplay between the TGFbeta pathway, Smad3, and the H3K27me3 histone demethylase (HDM) JMJD3 PMID: 22782721
    49. These results suggest that the demethylation of H3K27me3 in the Nfatc1 gene locus by Jmjd3 plays a critical role in RANKL-induced osteoclast differentiation. PMID: 21735477
    50. JMJD3 induces p53 stabilization in mouse NSCs through ARF-dependent mechanisms, directly interacts with p53 and, importantly, causes nuclear accumulation of p53. PMID: 21483786

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    UTX family
  • 數(shù)據(jù)庫鏈接：


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