在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Lysine-specific demethylase 5A (Kdm5a), partial

Recombinant Mouse Lysine-specific demethylase 5A (Kdm5a), partial

  • 中文名稱：
    小鼠Kdm5a重組蛋白
  • 貨號(hào)：
    CSB-YP667601MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kdm5a重組蛋白
  • 貨號(hào)：
    CSB-EP667601MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kdm5a重組蛋白
  • 貨號(hào)：
    CSB-EP667601MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kdm5a重組蛋白
  • 貨號(hào)：
    CSB-BP667601MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kdm5a重組蛋白
  • 貨號(hào)：
    CSB-MP667601MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kdm5a
  • Uniprot No.：
  • 別名：
    Kdm5a; Jarid1a; Rbp2; Lysine-specific demethylase 5A; EC 1.14.11.-; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2; RBBP-2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells.
  • 基因功能參考文獻(xiàn)：
    1. Conditional, systemic ablation of RBP2 in pituitary or thyroid tumor-bearing Rb1(+/-) mice is sufficient to slow tumor growth and significantly extend survival without causing obvious toxicity to the host. These findings show that established Rb1-null tumors require RBP2 for growth. PMID: 29610306
    2. KDM5A-mediated H3K4me3 modification participated in the etiology of osteoporosis and may provide new strategies to improve the clinical efficacy of BMP2 in osteoporotic conditions. PMID: 27512956
    3. Kdm5a associates with p50 and binds to the Socs1 promoter region in resting natural killer cells. PMID: 27050510
    4. Study reports that RBP2 is a demethylase that specifically catalyzes demethylation on histone H3 lysine 4, whose methylation is normally associated with transcriptionally active genes. PMID: 17320163
    5. JARID1a formed a complex with CLOCK-BMAL1 which was recruited to Per2 promoter;it increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1; JARID1a depletion shortened period of circadian rhythms PMID: 21960634
    6. KDM5A interacts physically with RBP-J PMID: 20231316
    7. mutation can downregulate cardiac cell proliferation by repressing cyclin D1 expression in the same way as jumonji PMID: 15081428
    8. A functional interplay between the PRC2 complex and the H3K4me3 demethylase Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells. PMID: 18483221

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Nucleus.
  • 蛋白家族：
    JARID1 histone demethylase family
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 三级4级全黄60分钟| 亚洲一区二区三区在线网址| 国产三级a三级三级| 日本熟妇大屁股人妻| 成年女人午夜毛片免费视频| 色欲色香天天天综合网站| 精品国产电影久久九九| 日本亚洲欧洲无免费码在线| 免费人妻精品一区二区三区| 国产精品无码av在线一区| 精品亚洲国产成人av制服| 丰满少妇熟乱xxxxx视频 | 久久久久亚洲精品| 欧美裸体xxxx极品少妇| 亚洲综合色区无码专区| 中文字幕一区二区三区精彩视频| 亚洲精品久久久久久无码色欲四季| 国产精品一国产精品一k频道| 妲己丰满人熟妇大尺度人体艺| 婷婷五月综合缴情在线视频| 99riav国产精品视频| 人妻系列无码专区喂奶 | 中国娇小与黑人巨大交| 精品www日韩熟女人妻| 亚洲欧洲日产韩国无码| 亚洲精品久久久一区| 成人做爰69片免费看网站| 人妻少妇邻居少妇好多水在线| 丰满少妇aaaaaa爰片毛片| 国产精品国产精品国产专区不卡| 国产精品永久免费视频| 欧美饥渴熟妇高潮喷水| √天堂中文最新版在线中文| 精品国产乱码久久久久久影片| 亚洲欧美日韩中文播放| 精品国产午夜福利在线观看| 国产精品三级一区二区| 女人下面毛多水多视频| 久九九精品免费视频| 野花社区在线观看视频| 西西人体大胆午夜啪啪|