在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Lysine-specific demethylase 2B (Kdm2b), partial

Recombinant Mouse Lysine-specific demethylase 2B (Kdm2b), partial

  • 中文名稱：
    小鼠Kdm2b重組蛋白
  • 貨號：
    CSB-YP757551MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kdm2b重組蛋白
  • 貨號：
    CSB-EP757551MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kdm2b重組蛋白
  • 貨號：
    CSB-EP757551MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kdm2b重組蛋白
  • 貨號：
    CSB-BP757551MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kdm2b重組蛋白
  • 貨號：
    CSB-MP757551MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kdm2b
  • Uniprot No.：
  • 別名：
    Kdm2b; Fbl10; Fbxl10; Jhdm1b; Kiaa3014Lysine-specific demethylase 2B; EC 1.14.11.27; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; [Histone-H3]-lysine-36 demethylase 1B
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
  • 基因功能參考文獻：
    1. tthat bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively PMID: 29166607
    2. Fbxl10 plays a critical role in migration by binding to the promoter region of migration-associated genes and thereby might influences cell behaviour to a possibly more aggressive phenotype. PMID: 27646113
    3. These results have not only identified an important epigenetic factor for iHep generation, but also brought new insight into the molecular nature of hepatogenesis and future biomedical applications for liver diseases. PMID: 27103435
    4. roles in long-term sustainable spermatogenesis via regulating cell cycle PMID: 26984996
    5. Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation. PMID: 25872778
    6. FBXL10 protects Polycomb-occupied promoters against ectopic de novo methylation. PMID: 25848754
    7. Genetic ablation in embryonic stem cells reveal that deletion of PRC1 has genome-wide effects on PRC2 occupancy and H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the PCGF1/PRC1 variant complex, is important for deposition of H2AK119ub1 and recruitment of PRC2 to a subset of CpG island targets and that this activity is essential for normal mouse development. PMID: 24856970
    8. Fbxl10 has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells. PMID: 23395003
    9. KDM2B silencing abrogated tumorigenicity of PDAC cell lines exhibiting loss of epithelial differentiation, whereas KDM2B overexpression cooperated with KrasG12D to promote PDAC formation in mouse models. PMID: 23321669
    10. a regulatory role of Fbxl10 in cell morphology, chemokine expression, and the metabolic control of fibroblasts. PMID: 22825849
    11. The KDM2B-let-7-EZH2 pathway contributes to the proliferation of immortal Ink4a/Arf null fibroblasts suggesting the histone-modifying enzyme functions more broadly in the regulation of cellular proliferation. PMID: 21757686
    12. Kdm2b/Jhdm1b functions as an oncogene and plays a critical role in leukemia development and maintenance. PMID: 21310926
    13. Results suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice. PMID: 21220025
    14. Data show that Ndy1 protects from hydrogen peroxide-induced apoptosis and G(2)/M arrest and inhibits ROS-mediated signaling and DNA damage, while knockdown of Ndy1 has the opposite effects. PMID: 18838535
    15. Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor PMID: 17296600
    16. Results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b). PMID: 18836456
    17. studies show that, in addition to inhibiting replicative senescence, Ndy1 inhibits Ras oncogene-induced senescence via a similar molecular mechanism PMID: 19202064

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Nucleus. Chromosome.
  • 蛋白家族：
    JHDM1 histone demethylase family
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲精品久久久久中文字幕| 亚洲www啪成人一区二区麻豆| 日本乱人伦在线观看| 日韩精品a片一区二区三区妖精| 人人爽人人爽人人片a| 成人精品一区日本无码网站 | 无码国产精品一区二区免费vr| 亚洲精品一区二区三区麻豆| 丰满人妻熟妇乱又伦精品app| 天堂av成年av影视| 国产欧美一区二区三区免费视频| 女被男啪到哭的视频网站 | 在线看免费无码av天堂的| 人妻人人做人碰人人添| 欧美孕妇变态重口另类| 成人亚洲a片v一区二区三区蜜臀 | 亚洲综合小说另类图片五月天| 亚洲无人区午夜福利码高清完整版| 精品国产午夜福利在线观看| 国产微拍精品一区二区| 色爽黄1000部免费软件下载| 无码国产乱人伦偷精品视频| 欧美成人h亚洲综合在线观看| 亚洲 制服丝袜 中文字幕 在线 | 国产成人无码精品久久涩吧| 国产女人乱子对白av片| 国产一精品一av一免费| 又黄又爽又猛的视频免费| 精品麻豆国产色欲色欲色欲www| 国产精品久久久久久tv| 中文字幕av免费专区| 久久欧美与黑人双交男男| 成年午夜精品久久久精品| 亚洲国产成人精品激情姿源| 精品人妻av区波多野结衣| 激情综合色综合啪啪五月丁香 | 久久精品黄aa片一区二区三区| 女人18毛片水真多免费看| 久久久精品人妻一区二区三区gv| 久久99国产精品久久| 国产自偷自偷免费一区|