在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Lys-63-specific deubiquitinase BRCC36 (Brcc3)

In Stock
  • 中文名稱:
    Recombinant Mouse Lys-63-specific deubiquitinase BRCC36(Brcc3)
  • 貨號:
    CSB-EP002798MOb1
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    (BRCA1-A complex subunit BRCC36)(BRCA1/BRCA2-containing complex subunit 3)(BRCA1/BRCA2-containing complex subunit 36)(BRISC complex subunit BRCC36)
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein of Isoform 1
  • 來源:
    E.coli
  • 分子量:
    40.7
  • 表達區域:
    2-291aa
  • 氨基酸序列
    AVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDIRSDSKFTYTGTEMRTVQEKMDTIRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHITIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMEELSSLE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
  • 基因功能參考文獻:
    1. The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 activity by promoting its deubiquitination. PMID: 23246432
  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族:
    Peptidase M67A family, BRCC36 subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 黑人巨茎大战欧美白妇免费| 最爽爱爱高潮免费视频| 情人伊人久久综合亚洲| 处破痛哭a√18成年片免费| 国产欧美日韩视频怡春院| 国产成人精品日本亚洲999| 欧美性受xxxx狂喷水| 最近2019中文字幕大全第二页| 国产丝袜足j在线视频播放| 在线观看的av免费网站| mm1313亚洲国产精品无码试看| 久久久无码一区二区三区| 日本无遮挡真人祼交视频| 久久精品亚洲乱码伦伦中文| 人人妻人人澡av天堂香蕉| 久激情内射婷内射蜜桃| 国产精品美女乱子伦高| 日本国产一区二区三区在线观看| 日本成本人片免费网站| 久久久精品国产sm最大网站| 亚洲成a∧人片在线观看无码| 国内精品伊人久久久久妇| 久久精品国产99国产精品| 精品一区二区ww| 成熟女人特级毛片www免费| 亚洲国产精品无码久久久不卡 | 日本三级带日本三级带黄| 美女扒开大腿让男人桶| 黑人大荫蒂高潮视频| 欧亚乱熟女一区二区三区在线| av一区二区国产在线视频| 国产精品.xx视频.xxtv| 亚洲欧美日韩国产综合一区二区| 国产成熟妇女性视频电影| 色婷婷综合缴情综免费观看| 日韩丰满少妇无吗视频激情内射| 99九九99九九视频精品| 中文字幕亚洲一区二区三区| 9l国产精品久久久久尤物| 玩弄少妇的肉体k8经典| 99国产欧美另娄久久久精品|