在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Liver carboxylesterase 1 (Ces1)

  • 中文名稱:
    Recombinant Mouse Liver carboxylesterase 1(Ces1)
  • 貨號:
    CSB-YP848671MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse Liver carboxylesterase 1(Ces1)
  • 貨號:
    CSB-EP848671MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse Liver carboxylesterase 1(Ces1)
  • 貨號:
    CSB-BP848671MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse Liver carboxylesterase 1(Ces1)
  • 貨號:
    CSB-MP848671MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Ces1
  • Uniprot No.:
  • 別名:
    Ces1; Ces1gLiver carboxylesterase 1; EC 3.1.1.1; Acyl-coenzyme A:cholesterol acyltransferase; Carboxylesterase 1G; ES-x
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    19-565
  • 氨基酸序列
    HP SLPPVVHTVH GKVLGKYVTL EGFSQPVAVF LGVPFAKPPL GSLRFAPPEP AEPWSFVKHT TSYPPLCYQN PEAALRLAEL FTNQRKIIPH KFSEDCLYLN IYTPADLTQN SRLPVMVWIH GGGLVIDGAS TYDGVPLAVH ENVVVVVIQY RLGIWGFFST EDEHSRGNWG HLDQVAALHW VQDNIANFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAIAQSSVI FNPCLFGRAA RPLAKKIAAL AGCKTTTSAA MVHCLRQKTE DELLEVSLKM KFGTVDFLGD PRESYPFLPT VIDGVLLPKA PEEILAEKSF NTVPYMVGIN KHEFGWIIPM FLDFPLSERK LDQKTAASIL WQAYPILNIS EKLIPAAIEK YLGGTEDPAT MTDLFLDLIG DIMFGVPSVI VSRSHRDAGA PTYMYEYQYR PSFVSDDRPQ ELLGDHADEL FSVWGAPFLK EGASEEEINL SKMVMKFWAN FARNGNPNGE GLPHWPEYDQ KEGYLQIGVP AQAAHRLKDK EVDFWTELRA KETAERSSHR EHVEL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
  • 基因功能參考文獻:
    1. Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury. PMID: 27881673
    2. Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin sensitivity. PMID: 26976727
    3. Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses. PMID: 24194565
    4. Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR-controlled lipid homeostasis PMID: 24038130
    5. Ces1/Es-x participates in the regulation of chylomicron assembly and secretion. PMID: 23145182
    6. These studies support a role for Ces1/Es-x in the partitioning of regulatory fatty acids and concomitant control of hepatic lipid biosynthesis, secretion, and deposition. PMID: 22806626
    7. Es-x limits hepatic triacylglycerol accumulation by promoting beta-oxidation. PMID: 19651238

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum lumen. Cytoplasm. Lipid droplet.
  • 蛋白家族:
    Type-B carboxylesterase/lipase family
  • 組織特異性:
    Detected in kidney, liver and lung.
  • 數據庫鏈接:

    KEGG: mmu:12623

    UniGene: Mm.22720



主站蜘蛛池模板: 精品久久久久久中文字幕| 影音先锋久久久久av综合网成人| 成年女人免费视频播放体验区 | 国产精品人成在线播放新网站| 成人网站免费高清视频在线观看| 国产三级精品三级在线观看| 亚洲欧美一区二区三区日产| 中文字幕av伊人av无码av| 亚洲成αv人片在线观看| 精品人无码一区二区三区| 欧美激情在线播放| 天天爱天天做天天爽夜夜揉| 人妻无码系列一区二区三区| 特级西西人体444www高清大胆| 牛牛在线视频| 老子午夜理论影院理论| av无码人妻中文字幕| 亚洲第一无码xxxxxx| 欧洲熟妇牲交| а√天堂www在线а√天堂资源| 久久精品中文字幕有码| 欧美激情a∨在线视频播放| 亚洲乱亚洲乱妇| 伊人伊成久久人综合网996| 双乳奶水饱满少妇呻吟| 欧美日韩欧美| 亚洲热无码av一区二区东京热av | 精品乱码一区内射人妻无码| 性欧美疯狂xxxxbbbb| 亚洲性线免费观看视频成熟 | 成人免费无码视频在线网站| 亚洲精品国偷自产在线| 熟女少妇精品一区二区| 92午夜少妇极品福利无码电影| 国产成人愉拍精品| av无码精品一区二区三区宅噜噜| 久久精品国产亚洲夜色av网站| 日本少妇寂寞少妇aaa| 美女视频黄频a免费| 呦男呦女视频精品八区| 成人无码视频在线观看网址|