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  4. Recombinant Mouse Linker for activation of T-cells family member 2 (Lat2), partial

Recombinant Mouse Linker for activation of T-cells family member 2 (Lat2), partial

  • 中文名稱：
    小鼠Lat2重組蛋白
  • 貨號：
    CSB-YP878051MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Lat2重組蛋白
  • 貨號：
    CSB-EP878051MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Lat2重組蛋白
  • 貨號：
    CSB-EP878051MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Lat2重組蛋白
  • 貨號：
    CSB-BP878051MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Lat2重組蛋白
  • 貨號：
    CSB-MP878051MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Lat2
  • Uniprot No.：
  • 別名：
    Lat2; Lab; Ntal; Wbscr15; Wbscr5; Linker for activation of T-cells family member 2; Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • 基因功能參考文獻：
    1. NTAL is a negative regulator of FcepsilonRI activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations. PMID: 25153696
    2. Our data define a novel link between LAB and beta-catenin nuclear accumulation in dendritic cells that facilitates IFN-gamma responses during anti-fungal immunity PMID: 23675302
    3. chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family PMID: 23443658
    4. Dihydrotestosterone treatment increased the expression of LAT2. PMID: 21606113
    5. Our study suggested a novel mechanism by which LAB functions in the regulation of innate immunity PMID: 22308309
    6. a crucial role of NTAL in signaling, via RhoA, to mast cell cytoskeleton. PMID: 21061444
    7. While SLP-76 and LAT1 depend on each other for many of their functions, LAT2/SLP-76 interactions and SLP-76-independent LAT1 functions also mediate a positive signaling pathway downstream of FcepsilonRI in mast cells. PMID: 20606011
    8. LAB is a critical, LAT-independent regulator of TREM-2 signaling and macrophage development capable of controlling subsequent inflammatory responses PMID: 19948717
    9. NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells. PMID: 15477348
    10. LAB shares a redundant function with LAT to play a positive role in FcepsilonRI-mediated signaling. PMID: 15477350
    11. LAB-deficient mice had increased levels of natural antibodies and slightly increased humoral response to a T-dependent antigen. PMID: 15899851
    12. LAB mediates immunoglobulin E-induced sustained Erk activation critical for mast cell survival. PMID: 17420272
    13. Our results show that system L isoform LAT2 is critical for alanine uptake into astrocytes. However, alanine does not provide any significant carbon for energy or neurotransmitter metabolism under the conditions studied. PMID: 17504263
    14. observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated. PMID: 17993265
    15. NTAL negatively regulates mast cell activation by decreasing the recruitment, by T cell activation linker (LAT), of molecules involved in Fc epsilon RI-dependent positive signaling. PMID: 18322174
    16. These data show that natural killer cell immunoreceptor tyrosine-based activation motifs preferentially use a signaling cassette regulated by interplay between LAT and LAB. PMID: 18645037
    17. LAT2 and LAT1 form separate membrane microdomains in bone marrow-derived mast cells. PMID: 17900607

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  • 亞細胞定位：
    Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
  • 組織特異性：
    Strongly expressed in testis. Expressed in heart, spleen and lung. Present in B-cells and mast cells (at protein level).
  • 數據庫鏈接：


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